移动学习App在药物化学教学中的应用

立足探索移动学习模式,结合药物化学的学科特点以及研究生学习实际情况,从药物化学信息、实验应用、药物设计等方面介绍相关移动学习App。结合案例比较移动学习及PC端的优劣。     

面向国家需求和科学前沿的“高等分析化学”研究生课程的建设与实施

高等分析化学是一门内容更新快、多学科交叉性强的实用性课程。在我校分析化学专业研究生的课堂教学中,该课程不仅内容繁琐、陈旧、抽象且系统性不强,而且课时相对较少。针对这些问题,及时更新教学观念,在课程定位、教材建设、教学方法、教学手段以及考核体系上进行改革,激发学生学习兴趣和热情,提高学生科研创新意识和解决实际问题的能力,从而全面提高该课程的教学质量。     

黏弹性材料等效分数阶微观结构标准线性固体模型

从黏弹性材料微观链结构出发,以橡胶基黏弹性材料超弹性理论分子网链高斯(Gauss)统计模型和黏滞流动理论为基础,研究黏弹性材料的微观结构、填料等对黏弹性性能的影响.用温频等效原理描述温度对黏弹性材料力学性能的影响,建立了可以有效描述黏弹性材料耗能特性的等效分数阶微观结构标准线性固体模型.采用动态热机械分析仪(DMA)对高聚物黏弹性材料力学性能、耗能能力进行测试.试验表明:在低温区域,储能模量较大,随着温度的升高,储能模量下降显著;能量损耗因子在高温和低温区域数值较小,在玻璃化转变温度附近数值较高.根据测试数据对所提等效分数阶微观结构标准线性固体模型进行验证,该力学模型能够较好地描述黏弹性材料储能模量和能量损耗因子随温度的变化趋势.用9050A和ZN22黏弹性材料对模型的有效性进一步验证,结果表明:9050A和ZN22黏弹性材料具有较好的耗能能力,所提出的等效分数阶微观结构标准线性固体模型能够准确地描述微观结构和填料对黏弹性材料宏观性能的影响,能够准确地描述黏弹性材料在不同温度和频率下的动态力学性能.     

Concurrent Detection of Protein Adsorption on Mixed Nanoparticles by Differential Centrifugal Sedimentation

In mixtures of nanoparticles of various sizes or compositions, monitoring protein partitioning on their surfaces provides important information about particle–protein interactions during competitive adsorption. Utilizing the size‐resolving capability of differential centrifugal sedimentation, the adsorption of bovine serum albumin on multisize gold nanoparticles with diameters ranging from 20 to 100 nm or gold, silver, and silica nanoparticles with similar diameter can be concurrently observed. This method can be used to gain insight into nanoparticle–protein interactions based on analyses of curvature and relative abundance.     

A tunable multi-wavelength Brillouin–erbium fiber laser with fourfold Brillouin frequency spacing

We have experimentally demonstrated a tunable multi-wavelength Brillouin–erbium fiber laser with over 40 GHz spacing utilizing two cascaded double Brillouin-frequency-spacing cavities. In this laser configuration, two segments of 25 km-long single-mode fibers are used as Brillouin gain medium in each ring cavity, and a segment of 8 m-long erbium-doped fiber with 980 nm pump is employed to amplify Brillouin pump (BP). At BP wavelength of 1550 nm, BP power of 8.3 dBm (6.8 mW) and the maximum 980 nm pump power of 27.78 dBm (600 mW), seven output channels with fourfold Brillouin-frequency spacing, and the tuning range of 15 nm from 1545 to 1560 nm are achieved. The proposed multi-wavelength Brillouin–erbium fiber laser has wide applications, such as in microwave signal generation and optical communications.     

Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag<Subscript>2</Subscript>S QDs/Metal − Organic Shell Composite

A novel fluorescence method for sensitive and selective detection of phosphate was developed based on near infrared emission Ag₂S QDs/ Metal ? Organic Shell Composite via the deposition of metal-organic (zinc-nitrogen) coordination shell around Ag₂S QDs . Under optimal conditions described, the fluorescence intensity of the composite was decreased at 685 nm in the presence of phosphate, which was linearly related to the concentration of phosphate in the range of 0. 7 to 4.2 μM and 11.2 to 88.2 μM with the relative correlation coefficient of R² = 0.998 and 0.987 respectively and detection limit as low as 6 nM. In addition, the proposed method was successfully utilized in serum samples, tap water and Yangtze River water samples with the recoveries ranged from 94.76 to 100.86 %, which presaged more opportunities for application in related bioassay and water sample researches.     

边孔弧形闸门水流脉动压力特性研究

弧形泄水闸是水利枢纽工程中常见的挡水、泄水建筑物,其在关闭或开启过程中或者局部开启运行时,在水流脉动压力作用下会产生振动,容易引起闸门结构破坏。本文针对边孔闸门与中孔闸门不同的水流边界条件特点,制作了带导流墙与无导流墙两个弧形闸门模型。在实验室内开展了不同库水位、不同闸门开度下的物理模型试验,并对两个模型上大量测点的水流脉动压力数据进行比较分析。试验表明,导流墙的存在对脉动压力主频的影响较小,但对脉动压力均方根值影响较大;在较高库水位下相对开度位于0.2至0.3区间内时,导流墙的存在不但不会改善闸门的受力状况,反而还会导致受力增强。     

瞬时环流反馈均流策略在EAST快控电源中的应用

在EAST 快控电源中采用瞬时环流反馈引入虚拟电阻的均流控制策略,可大大增加并联逆变器之间等效输出阻抗的实部,有效提高对环流低频分量的抑制能力。仿真和实验结果验证了该控制策略的可行性和有效性。     

基于J-TEXT 装置的光耦合隔离放大器设计与分析

基于反馈技术设计了一款带宽2.7MHz、高线性度、低传输延时的光耦合隔离放大器,仿真分析了 I-V 转换电路补偿电容对电路频率特性的影响,并选择了合适的电路参数。将部分寄生参数考虑在内,建立了电路数学模型,仿真、测试与理论分析相结合研究了电路的线性度与频率特性。基于J-TEXT 装置静电探针悬浮电位测量系统验证了电路在系统中的可用性。     

基于ICA的X射线医学图像目标提取

X射线医学成像能观察到患者体内病变组织,对医学诊断有重要参考价值。针对传统医学X射线图像噪声强、层次感差和器官组织重叠的问题,提出利用多能谱X射线成像结合独立成分分析(independent component analysis, ICA)进行图像去噪和目标提取。首先ICA结合稀疏编码收缩法对图像降噪预处理以保证目标提取精度;然后根据图像中各目标组成特性,分离图像中每个像素对应的目标厚度矩阵;最后ICA以盲分离理论获得收敛矩阵重建出目标对象。在ICA算法中,借助于主观评价标准,发现当收敛次数大于40时目标分离成功;当幅值尺度在[25, 45]区间内,目标图像对比度高且失真较小。同时,通过观测实验得到的三维峰值信噪比图表明：ICA算法中收敛次数和幅值对图像质量有较大影响,当重建图像的对比度和边缘信息均达到较好效果时,收敛次数与幅值为85和35。