Nonlinear dynamical magnetosonic wave interactions and collisions in magnetized plasma

The one-dimensional nonlinear dynamical wave interactions in a system of quasineutral two-fluid plasma in a constant magnetic field are investigated.The existence of the travelling wave solutions is discussed.The modulation stability of linear waves and the modulation instability of weakly nonlinear waves are presented.Both suggest that the Korteweg-de Vries(KdV) system is modulationally stable.Besides,the wave interactions including the periodic wave interaction and the solitary wave interactio...     

EAST中n=4共振磁扰动下等离子体的环向旋转制动

在EAST中n=4的共振磁扰动下观察到明显的等离子体旋转制动效应,其分布具有全局性,且峰值靠近等离子体中心。利用模拟得到的新经典环向粘滞(NTV)力矩来反演等离子体环向角速度的变化,结果表明在大部分径向区域与实验测量的速度变化符合得较好,量值上相差约1～2倍。     

Two birds one stone: β-fluoropyrrolyl-cysteine SNAr chemistry enabling functional porphyrin bioconjugation

Bioconjugation, a synthetic tool that endows small molecules with biocompatibility and target specificity through covalent attachment of a biomolecule, holds promise for next-generation diagnosis or therapy. Besides the establishment of chemical bonding, such chemical modification concurrently allows alteration of the physicochemical properties of small molecules, but this has been paid less attention in designing novel bioconjugates. Here, we report a “two birds one stone” methodology for irreversible porphyrin bioconjugation based on β-fluoropyrrolyl-cysteine S_NAr chemistry, in which the β-fluorine of porphyrin is selectively replaced by a cysteine in either peptides or proteins to generate novel β-peptidyl/proteic porphyrins. Notably, due to the distinct electronic nature between fluorine and sulfur, such replacement makes the Q band red-shift to the near-infrared region (NIR, >700 nm). This facilitates intersystem crossing (ISC) to enhance the triplet population and thus singlet oxygen production. This new methodology features water tolerance, a fast reaction time (15 min), good chemo-selectivity, and broad substrate scope, including various peptides and proteins under mild conditions. To demonstrate its potential, we applied porphyrin β-bioconjugates in several scenarios, including (1) cytosolic delivery of functional proteins, (2) metabolic glycan labeling, (3) caspase-3 detection, and (4) tumor-targeting phototheranostics.

This work demonstrates ‘two birds one stone’ β-fluoropyrrolyl-cysteine SNAr chemistry. This methodology not only achieves porphyrin peptide/protein conjugates but also induces attractive porphyrinic photophysical properties to facilitate promising biological applications.     

Fluorination of Terminal Groups Promoting Electron Transfer in Small Molecular Acceptors of Bulk Heterojunction Films

The fluorination strategy is one of the most efficient and popular molecular modification methods to develop new materials for organic photovoltaic (OPV) cells. For OPV materials, it is a broad agreement that fluorination can reduce the energy level and change the morphology of active layers. To explore the effect of fluorination on small molecule acceptors, we selected two non-fullerene acceptors (NFA) based bulk heterojunction (BHJ) films, involving PM6:Y6 and PM6:Y5 as model systems. The electron mobilities of the PM6:Y5 and PM6:Y6 BHJ films are 5.76 × 10⁻⁷ cm²V⁻¹s⁻¹ and 5.02 × 10⁻⁵ cm²V⁻¹s⁻¹ from the space-charge-limited current (SCLC) measurements. Through molecular dynamics (MD) simulation, it is observed that halogen bonds can be formed between Y6 dimers, which can provide external channels for electron carrier transfer. Meanwhile, the “A-to-A” type J-aggregates are more likely to be generated between Y6 molecules, and the π–π stacking can be also enhanced, thus increasing the charge transfer rate and electron mobility between Y6 molecules.     

浅议梁的强度与刚度的关系1)

本文提出了梁的强刚比的定义,用无量纲的形式定量地表达了梁的强度与刚度之间的关系,以期充分发挥材料的潜力并促进材料力学的课堂教学。强刚比与载荷大小无关,其数值可以通过有限元方法或者通过梁的载荷试验来获得。结合工程实际,从设计和试验两个方面对梁的强刚比 及其影响因素进行了简要地探讨和分析。     

Dielectric Properties Investigation of Metal–Insulator–Metal (MIM) Capacitors

This study presents the construction and dielectric properties investigation of atomic-layer-deposition Al₂O₃/TiO₂/HfO₂ dielectric-film-based metal–insulator–metal (MIM) capacitors. The influence of the dielectric layer material and thickness on the performance of MIM capacitors are also systematically investigated. The morphology and surface roughness of dielectric films for different materials and thicknesses are analyzed via atomic force microscopy (AFM). Among them, the 25 nm Al₂O₃-based dielectric capacitor exhibits superior comprehensive electrical performance, including a high capacitance density of 7.89 fF·µm⁻², desirable breakdown voltage and leakage current of about 12 V and 1.4 × 10⁻¹⁰ A·cm⁻², and quadratic voltage coefficient of 303.6 ppm·V⁻². Simultaneously, the fabricated capacitor indicates desirable stability in terms of frequency and bias voltage (at 1 MHz), with the corresponding slight capacitance density variation of about 0.52 fF·µm⁻² and 0.25 fF·µm⁻². Furthermore, the mechanism of the variation in capacitance density and leakage current might be attributed to the Poole–Frenkel emission and charge-trapping effect of the high-k materials. All these results indicate potential applications in integrated passive devices.     

葫芦脲：分子识别与组装

综述了葫芦脲这一类合成受体的最新研究进展，包括葫芦脲的分子设计与合成 ，离子和分子识别，键合的热力学性质，分子组装及其功能的最新研究概况。     

固态有机合成反应进展

以绿色合成为主题，综述了近期固相有机合成研究方面的一些新进展和典型反 应类型。由于固相反应的特征，多数固相有机反应表现出较溶液中更高的反应效率 和更好的选择性，并讨论了固态反应中的分子运动及其固态反应的因素。     

A DNA-mediated crosslinking strategy to enhance cellular delivery and sensor performance of protein spherical nucleic acids

Intracellular delivery of enzymes is essential for protein-based diagnostic and therapeutic applications. Protein-spherical nucleic acids (ProSNAs) defined by protein core and dense shell of oligonucleotides have been demonstrated as a promising vehicle-free enzyme delivery platform. In this work, we reported a crosslinking strategy to vastly improve both delivery efficiency and intracellular sensor performance of ProSNA. By assembling individual ProSNA with lactate oxidase (LOX) core into a nanoscale particle, termed as crosslinked SNA (X-SNA), the enzyme delivery efficiency increased up to 5–6 times higher. The LOX X-SNA was later demonstrated as a ratiometric probe for quantitative detection of lactate in living cells. More importantly, X-SNA probe showed significantly improved sensor performance with signal-to-noise ratio 4 times as high as ProSNA when detecting intracellular lactate.

By crosslinking protein spherical nucleic acid (SNA) into a supramolecular architecture X-SNA, the intracellular enzyme delivery efficiency was significantly enhanced, showing 3–4 times higher signal-to-noise ratio in detecting intracellular lactate.     

气相色谱-电子轰击源质谱法测定茶叶中氟虫腈残留量

建立了茶叶中氟虫腈残留量快速测定的气相色谱-电子轰击源质谱法。茶叶中的氟虫腈用正己烷-丙酮(7:3,V/V)混合液提取,经石墨化碳黑固相萃取小柱净化后,用正己烷-丙酮(9:1,V/V)混合液洗脱,浓缩定容后,用气相色谱-电子轰击源质谱法测定,外标法定量。结果表明,目标物质在0.001~0.040 mg/L范围内的线性关系良好;空白样品在0.002~0.010 mg/L范围三水平加标回收实验的平均回收率在96.6%~114.2%之间,相对标准偏差(n=6)为2.9%~4.4%;方法的定量限为0.001 mg/kg。该方法能满足茶叶中氟虫腈残留量0.002 mg/kg的检测要求。