不依赖于统计模型的手性毛细管电泳分离多指标同时优化

考虑到手性毛细管电泳分离机理的复杂性，提出了不依赖于统计模型的二进制编码遗传算法多目标优化策略。根据实验参数的多少及其重要性，采用均匀设计安排完成初步实验。并用Derringer功效函数作为多指标同时优化的评价指标，以取得较高的分离度和较快分离速度；通过对实验参数给予编码，转化为二进制字符串，根据得到的总功效函数值大小进行遗传算法操作，产生新的一组实验条件。重复上述过程直到得到最佳分离条件为止。此方法成功地应用于华法令对映体的毛细管电泳分离条件优化。     

Surface-renewable cobalt(II) hexacyanoferrate-modified graphite organosilicate electrode and its electrocatalytic oxidation of thiosulfate

Cobalt(II) hexacyanoferrate (CoHCF) was deposited on graphite powder by an in situ chemical deposition procedure and then dispersed into methyltrimethoxysilane-derived gels to prepare a surface-renewable CoHCF-modified electrode. The electrochemical behavior of the modified electrode in different supporting electrolyte solutions was characterized by cyclic voltammetry. In addition, square-wave voltammetry was employed to investigate the pNa-dependent electrochemical behavior of the electrode. The CoHCF-modified electrode showed a high electrocatalytic activity toward thiosulfate oxidation and could thus be used as an amperometric thiosulfate sensor.     

四磺化酞菁钴在微乳液、醇-水体系中的二聚现象研究

采用分光光度法研究了四磺化酞菁钴（ＣｏＴＳＰｃ），在微乳液（ＴｒｉｔｏｎＸ－１００－壬烷－正戊醇－水）、醇－水（甲醇、乙醇、丙醇）体系中的二聚现象，计算了ＣｏＴＳＰｃ的二聚常数ＫＤ。结果表明，ＣｏＴＳＰｃ的二聚常数ＫＤ值随着微乳液中表面活性的浓度及醇－水溶液的介电常数的增加而减小。     

An optical surface plasmon resonance biosensor for determination of tetanus toxin

Surface plasmon resonance (SPR) has been successfully applied for the simple, rapid, and label-free assay of various biomolecules. This assay evaluates a novel wavelength modulation SPR biosensor for the detection of tetanus toxin. The wavelength modulation SPR biosensor is designed based on fixing the incident angle of light and measuring the reflected intensities in the resonance wavelength range spanning 400-800 nm simultaneously. Tetanus toxin (TeNT), one of the most potent toxins known, is synthesized as a 150 kDa single polypeptide chain. The SPR biosensor has been shown to be capable of directly detecting concentration of tetanus toxin as low as 0.028 Lf ml⁻¹. Under selected experimental conditions, the SPR biosensor has a good reproducibility, sensitivity and reversibility. The results illustrate how wavelength modulation SPR biosensor can be used to detect biomolecular interactions.     

硼化合物的研究XX:乙醇胺合三(2-呋喃基)硼烷的合成及其转化

2-呋喃基锂与(N,N-二乙胺基)二氯硼烷的反应是以三烃基化的方式发生,因而可用于制取三(2-呋喃基)硼烷,并可以得到乙醇胺配合物1的稳定形式。乙醇胺合三(2-呋喃基)硼烷(1)可在稀酸中游离出三(2-呋喃基)硼烷,可与吡啶形成吡啶合三(2-呋喃基)硼烷2;化台物1中的呋喃环被8-羟基喹啉或8-羟基喹哪啶裂开以后,分别形成含 B-N 内配键的二呋喃基硼螯合物3及4。化合物1～4均经元素分析及有关波谱鉴定。     

THE POLYMERIZATION THERMOKINETICS OF PYRROLE IN THE PRESENCE OF IRON TRICHLORIDE

The polymerization thermokinetics of pyrrole in the presence of iron trichloride art studied by using a Calvet microcalorimoter. The apparent activation energy, the pre-exponential constant and reaction order of this reaction in the temperature range of 25.2—37℃are 34.5 KJ·mol~(-1), 10~(2.74)S~(-1) and 1 respectively. The activation free-energies of this reaction at 25.2°, 30°and 37℃are 91.8, 92.9 and 94.2 KJ·mol~(-1) respectively.     

联萘冠醚的合成新方法

一种用于合成含联萘基冠醚的新方法。以消旋，手性联萘酚为起始原料，先与氯乙醇反应制得2,2'-二（2－羟基乙氧基）－1,1'－联二苯，再与二甘醇或三甘醇对二对甲苯磺酸酯反应，成功制得了4种联萘冠醚。     

A fibrous hypercrosslinked sorbent prepared on PP-ST-DVB matrix via post-crosslinking reaction

A fibrous sorbent possessing abundant micropore structure was firstly prepared via post-crosslinking reaction on the PP-ST-DVB original fiber. Its micromorphology and sorptive properties were investigated, and the results demonstrated that the novel fibrous hypererosslinked sorbent has narrow pore-size distribution, small average porous radius （1.90 nm）, high specific surface area （362.31 m^2/g）, and fine sorptive properties for small organic molecules.     

水杨醛肟铜络合物中性载体高选择性水杨酸根电极的研究

采用合成的Schiff碱金属络合物水杨醛肟铜(Ⅱ)、锌(Ⅱ)、镍(Ⅱ)为中性载体制备阴离子选择性电极。结果表明水杨醛肟铜(Ⅱ)对水杨酸根(Sal-)具有高选择性及优良的电位响应性能,电极呈现反Hofmeister选择性行为,其选择性次序为Sal->ClO4->SCN->I->NO2->NO3->Br->Cl->OAc->SO42-。采用交流阻抗技术和紫外可见光谱技术研究了电极的响应机理。该电极具有响应快、重现性好、检出限低和制备简单等优点。将电极用于药品及人体尿液分析,结果令人满意。     

钨的溶剂萃取

本文简要地讨论了钨的溶剂萃取,重点讨论了萃取剂的结构对钨的萃取性能以及金属分离的影响。