Cationic polymerization of α-methylstyrene catalyzed by boron trifluoride etherate in 1,2-dichloroethane under an electric field

The cationic polymerization of α-methylstyrene with boron trifluoride etherate was studied in 1,2-dichloroethane under an electric field. The electric field was again found to increase the polymerization rate. This field effect was independent of monomer concentration, as was found previously. The effect, however, became greater as the catalyst concentration was lowered, unlike previous findings with various cationic systems. Furthermore, the field effect became smaller with rising temperature, whereas it had been practically independent of temperature in previous studies. The field effect increased linearly with the field strength. At 2.7 kv./cm. the rate was almost tripled. The field effect was small at lower dielectric constants, as had been observed previously. The large field effects observed and their “exceptional” behavior led to the interpretation that “partial” desolvation of free, growing chain ends, in addition to the field-facilitated dissociation, was responsible for the effect. Specific conductivities of polymerizing solutions and catalyst solutions were measured and are discussed.     

Measurements of the longitudinal and lateral development of electromagnetic cascades in lead, copper and aluminum at 6 GeV

The longitudinal and radial development of electromagnetic cascades, initiated by 6 GeV electrons, has been measured in lead, copper and aluminum by means of silver-phosphate dosimeter glasses. The measured energy deposition was compared with Monte-Carlo calculations by Völkel, especially at large depths and radii. Excellent agreement was found for the transition curves up to 40 radiation lengths and for the lateral distributions up to 4 Molière units. Between 4 and 12 Molière units the calculations tend to underestimate the energy deposition.     

Three-dimensional Lie group actions on compact (4n+3)-dimensional geometric manifolds

The (4n+3)-dimensional sphere S⁴ⁿ⁺³ can be viewed as the boundary of the quaternionic hyperbolic space and the group PSp(n+1,1) of quaternionic hyperbolic isometries extends to a real analytic transitive action on S⁴ⁿ⁺³. We call the pair (PSp(n+1,1),S⁴ⁿ⁺³) a spherical Q C-C geometry. A manifold M locally modelled on this geometry is said to be a spherical Q C-C manifold. We shall classify all pairs (G,M) where G is a three-dimensional connected Lie group which acts smoothly and almost freely on a compact spherical Q C-C manifold M, preserving the geometric structure. As an application, we shall determine all compact 3-pseudo-Sasakian manifolds admitting spherical Q C-C structures.     

Improved direct measurement of A(b) and A(c) at the Z(0) pole using a lepton tag

The parity violation parameters A(b) and A(c) of the Zb(b) and Zc(c) couplings have been measured directly, using the polar angle dependence of the polarized cross sections at the Z(0) pole. Bottom and charmed hadrons were tagged via their semileptonic decays. Both the electron and muon analyses take advantage of new multivariate techniques to increase the analyzing power. Based on the 1993-1998 SLD sample of 550,000 Z(0) decays produced with highly polarized electron beams, we measure A(b) = 0.919+/-0.030(stat)+/-0.024(syst), and A(c) = 0.583+/-0.055(stat)+/-0.055(syst).     

Application of 1-alkylamines to a liquid chromatographic/turbo ionspray tandem mass spectrometric method for quantifying metabolites of a new bone anabolic agent,TAK-778, in human serum

We investigated the application of alkylamines, as additives to the mobile phase, to a quantification method for the metabolites, M-III and M-IV, of TAK-778, which is a new bone anabolic agent, in human serum using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Prior to setting up the analytical method, we found that 1-alkylamines co-existing with M-III and M-IV in the turbo ionsprayed solution formed 1-alkylammonium adduct molecules of these metabolites during the ionization process, and the abundance of the adduct ions was considerably higher than that of protonated molecules ([M + H](+)s) of these metabolites. Based on these findings, we investigated a variety of 1-alkylamines and their spiked concentrations in the mobile phase for LC/MS/MS analysis to obtain higher sensitivities for the quantification of these metabolites. After these examinations, we found that 1-hexylamine at a final concentration of 0.05 mmol l(-1) was the most suitable additive for the mobile phase, and set the selected reaction monitoring (SRM) ions for the 1-hexylammonium adduct molecule and [M + H](+), allowing about a fivefold gain in the SRM chromatographic peak compared with that without 1-hexylamine. The adduct ion was considered to be formed by interaction between the amino group of 1-hexylamine and the phosphoryl group of M-III and M-IV. The internal standard (I.S.) used was deuterated M-III for each metabolite. The analytes and I.S. were extracted with diethyl ether from serum samples at neutral pH and injected into the LC/MS/MS system with a turbo ionspray interface. The limit of quantification for both analytes was 0.5 ng ml(-1) when 0.1 ml of serum was used, and the calibration curves were linear in the range 0.5-100 ng ml(-1). The method was precise; the intra- and inter-day precisions of the method were not more than 5.6%. The accuracy of the method was good, with deviations between added and calculated concentrations of M-III and M-IV being typically within 16.6%. This method provided reliable pharmacokinetic data for M-III and M-IV after the intramuscular administration of TAK-778 sustained-release formulation in humans.     

Synthesis of Chiral Crownophanes Having Two Phenolic Groups via Tandem Claisen Rearrangement and Their Chiral Recognition

Asymmetric crownophanes having a chiral binaphthyl unit and two phenolic hydroxyl groups were thermally synthesized from the corresponding macrocyclic ethers via tandem Claisen rearrangement. Circular dichroism (CD) spectroscopic studies and HPLC experiments confirmed that little racemization of these crownophanes occurred during the thermal rearrangement. The association constants for the interaction of the chiral crownophanes with the enantiomers of phenylethylamine, phenylglycinol, and phenylalaninol were determined by a ¹H NMR titration method in CD₂Cl₂. As a result, the 27 membered crownophane has some chiral recognition for phenylglycinol.     

Note on Locally Conformal Kähler Surfaces

The purpose of this note is to show that the complex two-dimensional locally conformal Kähler solvmanifold obtained by L. de Andres, Fernandez, Mencia and Cordero is holomorphically homothetic to the Inoue surface equipped with the locally conformal Kähler structure constructed by Tricerri. In order to prove it, we collect several facts related to the existence of locally conformal Kähler structure on compact complex surfaces.