Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D (NP/RP) LC-QToF MS method

An improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry (2D LC-QToF MS) system was developed for the lipid profiling of human plasma, in which different lipid classes were separated by the first dimensional normal-phase (NP) LC and different lipid molecular species were separated by the second dimensional reversed-phase (RP) LC. This 2D LC-QToF MS system was built based on a ten-port, two-position valve as the interface, the conditions of which had been optimized and discussed in detail. As two loops were used to trap and transfer the first dimensional elute to the second dimension separately, this new interface suppressed the sample band broadening in the first dimensional column, increased the recovery and repeatability of 2D LC interface, and offered the possibility for the realization of not-stop-flow NP/RP 2D LC system. Finally, 190 endogenous lipid species out of 10 lipid classes were determined within a single run from the plasma of peritoneal patients. This method was also applied to identify the difference in lipid profile between plasma from peritoneal dialysis patients with bad volume status and peritoneal dialysis patients with good volume status. The discovery of 30 potential biomarkers would be helpful to the malnutrition, inflammation, and atherosclerosis syndrome investigation.     

Development and validation of a rapid and sensitive assay for the determination of anisodamine in 50 μL of beagle dog plasma by LC–MS/MS

A simple, rapid, high‐throughput, and highly sensitive LC–MS/MS was developed to determine anisodamine in a small volume (50 μL) of beagle dog plasma using atropine sulfate as the internal standard. The analyte and internal standard were isolated from 50 μL plasma samples after a one‐step protein precipitation using Sirocco 96‐well protein precipitation filtration plates. The separation was accomplished on a Hanbon Hedera CN column (100 × 4.6 mm, 5 μm) and the run time was 4 min. A Micromass Quatro Ultima mass spectrometer equipped with an ESI source was operated in the multiple reaction monitoring mode with the precursor‐to‐product ion transitions m/z 306.0→140.0 (anisodamine) and 290.0→123.9 (atropine) used for quantitation. The method was sensitive with a low LOQ of 0.05 ng/mL, and good linearity in the range 0.05–50 ng/mL for anisodamine (r² ≥ 0.995). All the validation data, such as accuracy, intra‐ and interrun precision, were within the required limits. The method was successfully applied to the pharmacokinetic study of anisodamine hydrochloride injection in beagle dogs.     

基于SEDRIS的虚拟试验合成环境建模技术研究

为解决合成环境的统一描述和可交互问题,在分析合成环境数据表示与转换标准SEDRIS基础上,提出了基于SEDRIS的虚拟试验合成环境建模方法,针对大气、红外、电磁等3类自然环境,给出了实现环境数据表示和转换的技术途径。通过系统开发,实现了4种试验环境条件下对产品性能的验证与评估,建立的环境模型具有良好的交互性,建模方法可应用于多种试验环境的描述,为虚拟试验合成环境模型体系、标准规范和辅助工具的形成打下了基础。     

Aggregation-induced dual-color luminogen with enhanced chiroptical property

Science China Chemistry -     

Surface resonant-states-enhanced acoustic wave tunneling in two-dimensional phononic crystals

We show that by placing a metal plate next to a two-dimensional phononic crystal, acoustic waves can tunnel through the combined structure at a specific frequency that lies inside the band gap of the phononic crystal. The enhanced transmission is attributed to the coupling of the input waves with the acoustically resonant states created between the metal plate and the phononic crystal. Experiments are in excellent agreement with the theoretical predictions.     

Improved optical single-sideband generation using the self-modulation birefringence difference in semiconductor optical amplifiers

By employing the self-modulation birefringence difference in a semiconductor optical amplifier (SOA), an improved method is proposed to generate a complete optical single-sideband (OSSB) signal. Over 30 dB sideband suppression ratios (SSRs) of lower OSSB signals are obtained over a 12 dB input power range and a 36 nm wavelength span, with a maximum of over 35 dB. Upper OSSB signals with an SSR of over 15 dB are observed using a SOA for what is believed to be the first time. This method is effective even for the carrier-suppressed signal. The theory for OSSB generation in an SOA is extended and verified by experiment.     

Evaluation of Poly(glycidyl methacrylate)-Coated Column for Enantioseparation with Azithromycin Lactobionate and Clindamycin Phosphate as Chiral Selectors in Capillary Electrophoresis

Chromatographia - In this study, a poly(glycidyl methacrylate) nanoparticle (PGMA NP)-coated column system with two antibiotics as selector was constructed for enantioseparation. The PGMA NP...     

Dyeing behavior and mechanism of Crocein Orange G on carboxymethyl cotton fabric

Cellulose - Traditional cotton fiber dyeing requires an abundance of salt, which leads to environmental pollution. Consequently, decreasing or eliminating the use of salt has become the primary...