300和600keV O~(7+)离子与宏观玻璃管的相互作用

实验研究了300和600 ke V的O7+离子与宏观玻璃管内壁的相互作用,利用位置灵敏法拉第筒测量了传输离子的偏转角和传输效率随倾斜角的变化关系,观察到偏转角不等于倾斜角的不完全导向现象。实验结果证实,高能入射离子在玻璃管内壁产生的沉积电势相对于入射离子动能横向分量较小,难以使传输离子沿着玻璃管的轴向出射,从而发生不完全导向现象;并且,入射离子的能量越高,导向效应越不明显。     

Direct electrochemistry and electrocatalysis of hydrogen peroxide using hemoglobin immobilized in hollow zirconium dioxide spheres and sodium alginate films

A biocompatible composite made from hollow zirconium dioxide microspheres (HZMS) and sodium alginate (SA) is presented and used for the construction of a biosensor for hydrogen peroxide using a gold electrode. The composition, morphology and size were studied by transmission electron microscopy. FT-IR and UV-vis spectroscopy revealed that hemoglobin (Hb) entrapped in the ZHMS retains its native structure. A pair of stable and well-defined quasi-reversible redox peaks of Hb is obtained, with a formal potential of ?0.15 V at pH 7.0. The apparent heterogeneous electron transfer rate constant is 1.15 s^?1, indicating facile electron transfer that may result from the unique nanostructures and larger surface area of the HZMS. The amperometric response of the sensor varied linearly with the concentration of hydrogen peroxide in the range from 1.75 µM to 4.9 mM, with a detection limit of 0.6 µM (at S/N?=?3). The apparent Michaelis-Menten constant $ \left( {K_{\rm{M}}^{\rm{app}}} \right) $ is 1.6 mM. The biosensor possesses high sensitivity, good reproducibility, and long-term stability.     

Effect of Coordination on the Glucose‐Responsiveness of PEG‐b‐(PAA‐co‐PAAPBA) Micelles

Poly(ethylene glycol)‐block‐poly(acrylic acid) (PEG‐PAA) is modified by 3‐aminophenylboronic acid (APBA) with different modification degrees, such as PEG₁₁₄‐b‐(PAA_0.37‐co‐PAAPBA_0.63)₁₇₀, PEG₁₁₄‐b‐(PAA_0.23‐co‐PAAPBA_0.77)₁₇₀ and PEG₁₁₄‐b‐(PAA_0.02‐co‐PAAPBA_0.98)₁₇₀. Micelles self‐assembled from these three copolymers possess glucose‐responsiveness at varying pH values. Micelles self‐assembled from PEG₁₁₄‐b‐(PAA_0.37‐co‐PAAPBA_0.63)₁₇₀ have glucose‐responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. ¹¹B magic‐angle spinning nuclear magnetic resonance (¹¹B MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose‐responsiveness of PEG₁₁₄‐b‐(PAA_0.37‐co‐PAAPBA_0.63)₁₇₀ micelles at pH 7.4.

     

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??How to solve the inference problem of candidate database web surveys is an urgent problem to be solved in the development of web survey. In order to solve this problem, the inference method of non-probability sampling based on superpopulation pseudo design and the combined sample is proposed. A superpopulation model is firstly built up to construct pseudo weights for a survey sample of the web candidate database. The estimator of the population mean is then computed according to the combined sample composed of the survey sample of the web candidate database and a probability sample. The variance estimator of the population mean estimator is lastly derived according to the variance estimation theory of the superpopulation model. The Bootstrap and Jackknife methods are also used to compute the variance estimator. And all these variance estimation methods are compared. The research results show that the population mean estimator based on superpopulation pseudo design and the combined sample is better, and has higher efficiency than the estimator only using the probability sample and the weighted estimator only using the survey sample of the web candidate database. The variance estimator computed by using the VM1, VM2 and VM3 method are relatively better.     

Microstructure and oxidation of hot-dip aluminized titanium at high temperature

High-temperature diffusion of a hot-dip aluminized titanium is conducted to study microstructure changes and oxidation behavior of the aluminized titanium. After aluminizing, the titanium substrate is covered by a black layer in which tiny block-shaped TiAl₃ particles are scattered in aluminum matrix. Based on the diffusion experiment results, the thickness of the aluminum diffusion layer at 800 °C increases with diffusion time. However, the aluminum diffusion layer at 900 °C grows and reaches its maximum thickness in 6 h, and then the thickness of the aluminum diffusion layer is reduced with prolonged diffusion time. An inversion of the diffusion layer thickness versus time appears for the aluminized titanium treated at 1000 °C, and the thickness of the diffusion layer keeps declining with diffusion time. The phases present in the outer and middle sublayers are titanium-rich TiAl₃ and equilibrium TiAl₃, respectively. However, the phase in inner sublayer changes from titanium-rich TiAl₃ to TiAl₂ and TiAl as diffusion temperature and time increase. Through energy-dispersive X-ray and X-ray diffraction analysis, the oxides formed in the oxidation process are Al₂O₃ and Al₂TiO₅. Although the oxide scale formed on the surface of the aluminized titanium has an insufficient stability and integrity, the thermal oxidation resistance of the aluminized titanium is still improved by over 5 times compared with that of the pure titanium.     

退火质子交换平面波导型电光调制器的研究

基于双棱镜耦合m线技术提出了一种新型的平面波导强度调制器。由于质子交换平面波导的导波层在加上电场后折射率发生变化，从而引起棱镜耦合输出的m线强度的变化，实现电光调制。讨论了电极间隙宽度和导波层吸收对器件性能的影响。与其他类型强度调制器相比，这种调制器具有简单的电极结构，而且调制带宽可达40GHz以上。     

激光光散射研究丙烯酰胺丙烯酸共聚物的溶液行为

用激光光散射技术研究了丙烯酰胺 丙烯酸共聚物 (简称P(AM AA) )的溶液行为 .结果表明 ,纯水中P(AM AA)分子的流体力学半径Rh的分布存在 10 0～ 5 0 0nm的范围 ,与溶液中的网状结构对应 .当加入NaCl后 ,Rh 分布变窄 ,集中在 10 0nm以下的范围内 ,10 0～ 5 0 0nm这一范围消失 ,说明P(AM AA)在纯水溶液中主要以网状结构存在 ,小分子盐如NaCl的加入会破坏这种网状结构 .网状结构的破坏导致溶液稳定性下降 ,在0 1mol LNaCl溶液中 ,当c c 时 ,放置一段时间后 ,溶液中出现白色絮状沉淀 .     

Maintenance of Amyloid β Peptide Homeostasis by Artificial Chaperones Based on Mixed‐Shell Polymeric Micelles

The disruption of Aβ homeostasis, which results in the accumulation of neurotoxic amyloids, is the fundamental cause of Alzheimer’s disease (AD). Molecular chaperones play a critical role in controlling undesired protein misfolding and maintaining intricate proteostasis in vivo. Inspired by a natural molecular chaperone, an artificial chaperone consisting of mixed‐shell polymeric micelles (MSPMs) has been devised with tunable surface properties, serving as a suppressor of AD. Taking advantage of biocompatibility, selectivity toward aberrant proteins, and long blood circulation, these MSPM‐based chaperones can maintain Aβ homeostasis by a combination of inhibiting Aβ fibrillation and facilitating Aβ aggregate clearance and simultaneously reducing Aβ‐mediated neurotoxicity. The balance of hydrophilic/hydrophobic moieties on the surface of MSPMs is important for their enhanced therapeutic effect.     

增益随机变化对分布放大暗孤子传输系统的影响

基于分布放大暗孤子传输系统的增益随机变化，利用守恒量扰动法，研究了增益随机变化对暗孤子到达检测窗口时间抖动的影响，结果表明，增益随机变化对暗孤子速度产生了影响。，并增大了暗孤以达时间的抖动，引入非线性增益可以有效抑制增益随机变化增大的暗孤子到达时间的抖动。