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101.
102.
以北京师范大学化学专业的无机化学课程改革为例,从教学内容、教学方法、课程考核等方面探讨无机化学课程优化和改革。明确教学目标,提升教学质量,达成化学(师范)专业的毕业要求,全面提升学生的思想政治素养、专业知识技能和教育情怀。 相似文献
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Weifeng Zhang Gaocai Li Rongjin Luo Jie Lei Yu Song Bingjin Wang Liang Ma Zhiwei Liao Wencan Ke Hui Liu Wenbin Hua Kangcheng Zhao Xiaobo Feng Xinghuo Wu Yukun Zhang Kun Wang Cao Yang 《Experimental & molecular medicine》2022,54(2):129
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue. Excessively accumulated cytosolic DNA acts as a damage-associated molecular pattern (DAMP) that is monitored by the cGAS-STING axis to trigger the immune response in many degenerative diseases. NLRP3 inflammasome-dependent pyroptosis is a type of inflammatory programmed death that promotes a chronic inflammatory response and tissue degeneration. However, the relationship between the cGAS-STING axis and NLRP3 inflammasome-induced pyroptosis in the pathogenesis of IVD degeneration remains unclear. Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated pyroptosis in a STING-dependent manner in human NP cells. Interestingly, the canonical morphological and functional characteristics of mitochondrial permeability transition pore (mPTP) opening with the cytosolic escape of mitochondrial DNA (mtDNA) were observed in human NP cells under oxidative stress. Furthermore, the administration of a specific pharmacological inhibitor of mPTP and self-mtDNA cytosolic leakage effectively reduced NLRP3 inflammasome-mediated pyroptotic NP cell death and microenvironmental inflammation in vitro and degenerative progression in a rat disc needle puncture model. Collectively, these data highlight the critical roles of the cGAS-STING-NLRP3 axis and pyroptosis in the progression of IVD degeneration and provide promising therapeutic approaches for discogenic LBP.Subject terms: Cell death, Diseases 相似文献
105.
基于时滞动力学模型对钻石公主号邮轮疫情的分析 总被引:1,自引:0,他引:1
2019年末以来,新型冠状病毒肺炎迅速蔓延的疫情引发了全球关注.文献[5-6]提出了一类时滞动力学系统的新冠肺炎传播模型用以描述疫情的发展趋势.文献[7]在此基础上,结合CCDC统计数据,提出了一类基于CCDC统计数据的随机时滞动力学模型.本文将使用以上两类模型研究分析"钻石公主号"邮轮的疫情发展.基于日本厚生劳动省公布的数据,本文准确反演出模型参数,进而有效模拟当前疫情的发展,并预测疫情未来的趋势,发现在疫情爆发初期基本再生数R0(t)较大,而后随着防控措施加强而逐渐减小;约在2月下旬,累计确诊人数增长速度放缓,在3月上旬,累计确诊人数趋于稳定,即无新增确诊人数,疫情得到有效控制;最终累计确诊人数对隔离率变化敏感,隔离率升高,最终累计确诊人数将有显著下降.针对传染率较高、隔离率较低的问题,本文建议日本政府进一步加强防控措施,抑制疫情的大规模爆发. 相似文献
106.
Man Duan Dongmei Han Nan Gao Wenbin Shen Kun Chang Xinyu Wang Jianshi Du 《Molecules (Basel, Switzerland)》2022,27(5)
Porous organic polymers have an open architecture, excellent stability, and tunable structural components, revealing great application potential in the field of fluorescence imaging, but this part of the research is still in its infancy. In this study, we aimed to tailor the physical and chemical characteristics of indocyanine green using sulfonic acid groups and conjugated fragments, and prepared amino-grafted porous polymers. The resulting material had excellent solvent and thermal stability, and possessed a relatively large pore structure with a size of 3.4 nm. Based on the synergistic effect of electrostatic bonding and π–π interactions, the fluorescent chromogenic agent, indocyanine green, was tightly incorporated into the pore cavity of POP solids through a one-step immersion method. Accordingly, the fluorescent chromogenic POP demonstrated excellent imaging capabilities in biological experiments. This preparation of fluorescent chromogenic porous organic polymer illustrates a promising application of POP-based solids in both fluorescence imaging and biomedicine applications. 相似文献
107.
Hongmei Shao Wei Wu Wenbin Liu 《高等学校计算数学学报(英文版)》2007,16(3):193-202
The capability of multilayer perceptrons(MLPs)for approximating continuous functions with arbitrary accuracy has been demonstrated in the past decades.Back propagation(BP)algorithm is the most popular learning algorithm for training of MLPs.In this paper,a simple iteration formula is used to select the leaming rate for each cycle of training procedure,and a convergence result is presented for the BP algo- rithm for training MLP with a hidden layer and a linear output unit.The monotonicity of the error function is also guaranteed during the training iteration. 相似文献
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Fanbo SongJing Zhang Quanbin CuiTing Wang Wenbin ChenLuyuan Li Zhen Xi 《Tetrahedron letters》2012,53(9):1102-1104
Inositol phosphates regulate important biological functions in intracellular signal transduction events. Phosphonates, because of the stability towards the action of phosphatases, were extensively used to replace phosphates. We herein reported the synthesis of inositol phosphonate analogues using myo-inositol as the starting material, and found that two of phosphonate analogues exhibited relative good cytotoxic activity against non-small cell lung cancer (NSCLC) cell line A549. 相似文献
110.
A series of well-defined enantiopure 1,1'-binaphthyl-based oligomers linked through their 6,6'-positions, ranging from quaternaphthol to decanaphthol, have been synthesized by Suzuki and Stille coupling reactions. These novel oligonaphthyls have been characterized by (1)H and (13)C[(1)H] NMR spectroscopy and high-resolution mass spectrometry. A combination of X-ray structural and CD studies suggests that these oligonaphthyls adopt zigzag but not helical conformations. As the chain length increases, the compounds show enhanced fluorescence. The fluorescence intensity of oligonaphthols is almost 2 orders of magnitude higher than that of 1,1'-bi-2-naphthol and can be effectively and enantioselectively quenched with trans-1,2-diaminocyclohexane with an enantioselectivity factor of 1.24. The present work thus demonstrates the potential of constructing chiral sensory materials based on well-defined enantiopure oligonaphthols. 相似文献