Calculation of skin permeability coefficient for ionized and unionized species of indomethacin.

The contribution of ionized and unionized species to the overall permeation of weak electrolytes through the skin was investigated to determine the effect of pH in the vehicle on the permeability of indomethacin (IDM), as a model drug, through hairless rat skin. The permeability of IDM through polydimethylsiloxane (silicone) and poly(2-hydroxyethyl methacrylate) (pHEMA) membranes which may reflect lipid and aqueous pathway, respectively, was also measured for comparison. As the pH in the vehicle increased, there was an exponential increase in the skin permeation rate of IDM. The permeation rate of IDM through the silicone membrane was constant independent of pH, whereas that through the pHEMA membrane increased with increasing pH, similar to the skin permeation. The permeability coefficients of ionized and unionized species through the skin estimated using the skin permeation rates and solubilities of IDM at various pHs were 1.50 x 10(-7) and 2.79 x 10(-5) cm/s, respectively. These results indicated that the permeation of ionized species greatly contributed to the total permeation of IDM at higher pH, and that the total permeation rate of IDM was determined by the permeation of unionized species at lower pH. These contributions depend on the pH and pKa values and the ratio of permeability coefficient of each species. It was also confirmed that the skin has at least two kinds of permeation pathways and these two species permeate through a different pathway.     

Pulsed photothermal phase-shift spectroscopy for weak absorption measurement

A novel photothermal phase-shift spectroscopy configuration based on the retro-reflected beam interference has been developed and its operational principle is described. The weak absorption measurement ability of this technique is experimentally proven with a water/ethanol solution of standard Pyronine G dye and the limit of detection is found to be 1.8 x 10(-6) absorbance. Potential applications of the technique are discussed.     

Some inequalities for partial orders

We establish some inequalities connecting natural parameters of a partial order P. For example, if every interval [a,b] contains at most maximal chains, if some antichain has cardinality v, and if there are ₁ chains whose union is cofinal and coinitial in P, then the chain decomposition number for P is ₁v (Theorem 2.2), and the inequality is sharp in a certain sense (Section 3).This paper was written while the authors were visitors at the Laboratoire d'algèbre ordinale, Département de Mathématiques, Université Claude Bernard, Lyon 1, France.Research supported by NSERC grant # A5198.     

An introduction to covariant superstring field theories

A pedagogical account is given of the recent developments in covariant (super)string field theories. After reviewing the construction of the free open bosonic string field theory, the super-symmetric case is treated and the space-time supersymmetry transformations are explained. The present status and some future problems are also summarized.Invited talk presented at the International Conference Selected Topics in Quantum Field Theory and Mathematical Physics, Bechyn, Czechoslovakia, June 23–27, 1986.On leave of absence fromNational Laboratory for High Energy Physics (KEK), Tsukuba, Ibaraki, Japan.I would like to thank A. Neveu, H. Nicolai and P. West for many discussions, and the CERN Theoretical Physics Division for hospitality and generous support.     

Transient behavior of a nonequilibrium plasma formed by merged beams

A low density, low temperature plasma formed by two merged beams of electrons and ions at near zero relative velocity is studied by solving a set of time-dependent rate equations. In particular, we investigate the role played by the radiative recombination (RR) and three-body recombination (TBR) on the population of excited states during the initial stage of plasma rearrangement and relaxation. It is found in the case of hydrogenic plasmas that low-lying states are filled predominantly by RR, while high Rydberg states are populated mainly by TBR. As the plasma further relaxes, the collisional excitation and de-excitation, and radiative decays become important, filling the median excited states. The dependence of the TBR and RR rates on ionic chargeZ is discussed to extend the result to plasmas of highZ ions.     

Etude cristallographique de l'arsénotellurure de zirconium quadratique

Single crystals of zirconium arsenotelluride (PbFCl type) have been prepared by direct synthesis from the elements. Chemical analysis gives: $\text{As}\text{Zr}\text{= 1.43 ± 0.02}$ and $\text{Te}\text{Zr}\text{= 0.46 ± 0.01}$, in atoms. Lattice constants are: a = 3.82 ± 0.01 Å and c = 8.17 ± 0.02Å. Experimental density is equal to 7.14 ± 0.05. Unit cell thus contains Zr_2.00As_2.86Te_0.92. The structure has been solved with 227 reflections of a single crystal recorded at room temperature. The final R factor is 0.081, excluding zero reflections. Part of the arsenic atoms fills a site and the remainder is located in a second site, the occupation of which is completed by a part of zirconium atoms. The third site is occupied, but not filled, by the tellurium atoms and the remainder of zirconium atoms.     

BINDING, EXCITATION ENERGY TRANSFER AND PHOTOSENSITIZATION IN GRISEOFULVIN-DNA MIXTURES

Abstract— The weak and reversible binding of the antifungal drug, griseofulvin (GF), to calf thymus DNA has been demonstrated by difference spectroscopy and the quenching of the fluorescence of GF by DNA observed. The value of K _n was determined to be 800 M ^-1by fluorescence quenching titration. Adenosine and guanosine also exhibit difference spectra with GF and quench GF fluorescence indicating that they may be the site of both binding and energy transfer. The in vitro photosensitization of DNA by griseofulvin is shown to occur. It is proposed that the clinically observed in vivo photosensitizing action of griseofulvin may result from binding followed by excitation energy transfer and that this may also be important in the antifungal activity of the drug.     

Radiation degradation of copolymers of methyl methacrylate and 3-oximino-2-butanone methacrylate

Copolymers of methyl methacrylate and 3-oximino-2-butanone methacrylate (OM) were investigated as deep-UV and e-beam resists. Their increased sensitivity relative to PMMA (up to 50 times) was correlated with the radiation chemical yields of the volatile products and main chain scissions. The degradation of these copolymers, activated by the 3-oximino-2-butanone entity, is discussed in terms of energy absorption mechanisms and the subsequent scission reactions.