产学研视角下现代产业学院建设的模糊综合评价

以现代产业学院的发展内涵与特征为出发点, 构建合作主体产学研协同的现代产业学院建设绩效的评价指标体系, 对该体系的专家打分数据进行收集, 采用模糊综合评价方法加以分析, 确定各指标的权重, 并结合某高校G现代产业学院实际案例的评价分析结果, 对该现代产业学院的发展提出相应的对策与建议.     

可化约拟线性双曲组带一类非局部边界条件的精确边界能控性

先证明了一类非线性积分方程解的存在唯一性,利用此结果,建立了可化约拟线性双曲组带一类非局部边界条件的单侧精确边界能控性.     

适用于中、小动物的迅速减压舱的研制及其实验研究

研制一种新型的、适用于中、小动物的迅速减压舱。通过１３８ 次空载实验和３６ 例动物（ 家兔） 实验发现:该装置的减压幅度和减压时间可调,减压幅度最大可达９８０６６５Ｐａ,减压时间为７～３３６ｍｓ;减压时间与节流面积近似呈反比关系,与减压幅度呈负相关;减压精度较高,可产生不同程度的肺损伤,伤情重复性较好;能模拟多种迅速减压环境,尤其是减压速率很快的减压环境,可为冲击伤和减压损伤的发生机制及救治研究提供重要的致伤模型和实验手段。     

四气门汽油机中滚流运动的三维数值模拟

四气门汽油机中空气运动以滚流为主,滚流有助于改善燃烧过程．本文用ＡＬＥ方法进行了四气门汽油机中滚流运动的三维数值模拟．计算结果展示了在滚流缸内三维空间中形成及演变过程,及其湍动能场的变化规律．与实验结果的比较表明两者吻合较好,验证了计算结果的可靠性．     

Theoretical study of dynamical properties on reaction path in molecular internal coordinates

The dynamical properties on reaction path (IRC) in internal coordinates have been obtained, which in. clude ω_K (frequencies orthogonal to IRC), L_K (vibrational modes), B_(KF) (coupling constants between the IRC and vibra tions orthogonal to it), B_(KL) (coupling constants between every two vibrations orthogonal to IRC). A set of theory of teac. tion path in molecular internal coordinates has been also constructed. The dynamical properties, including ω_K, B_(KF) B_(KL) of the reaction H~1O~2H~3 H~4→H~1O~2 H~3H~4 have been calculated, which explicitly explain the interaction, chang ing trend and contribution of each chemical bond (including bond angle) in the reaction.     

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.     

Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(II) complexes of the Schiff base of glycine

The conjugate addition of Ni(II) complexes of glycine Schiff base to α,β-unsaturated aldehydes catalyzed by (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine afforded adducts in excellent yields with up to 49:1 dr and 95% ee. This method enables the construction of two adjacent chiral centers in one step, and offers an alternative route to chiral α-amino acid derivatives.     

Drug-induced glucose-6-phosphate dehydrogenase deficiency-related hemolysis risk assessment

Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme that protects human red blood cells from premature destruction caused by oxidative damage. People suffering from G6PD deficiency would be vulnerable to various oxidative substances, such as fava beans and oxidant drugs. Until now, many institutes, organizations or domain experts have compiled low-risk or high-risk drugs collection for patients with G6PD deficiency, mainly from the case report or clinical trails. Recently, we have explored a classification system to predict drug-induced hemolytic potential. In this paper, we screen the normally used over-the-counter (OTC) drugs for "high-risk" and "low-risk" ones to G6PD deficient patients by this system.     

Engineering oxide resistive switching materials for memristive device application

Based on a unified physical model and first-principle calculations, a material-oriented methodology has been proposed to control the bipolar switching behavior of an oxide-based resistive random access memory (RRAM) cell. According to the material-oriented methodology, the oxide-based RRAM cell can be designed by material engineering to achieve the required device performance. In this article, a Gd-doped HfO₂ RRAM cell with excellent bipolar switching characteristics is developed to meet the requirements of memristive device application. The typical memristive characteristics of the Gd-doped HfO₂ RRAM cell are presented, and the mechanism is discussed.     

Spectroscopic Studies on the Toxic Interaction of Sodium Oleate with Bovine Serum Albumin

The effects of sodium oleate on Bovine Serum Albumin (BSA) were investigated by fluorescence, synchronous fluorescence, ultraviolet–visible and circular dichroism spectroscopy. According to the experiment results, we found that the fluorescence intensity of BSA was quenched by sodium oleate following a static mode, a sodium oleate-BSA complex was formed and the binding site was calculated approximately equal to 1. The experimental results showed that the hydrophilic group (—COONa) can bind to the BSA and lead to the looser of the protein conformation, the microenvironment and the secondary structure elements were changed in the presence of sodium oleate. This work reflected the toxic interaction mechanism of BSA and sodium oleate from the perspective of spectroscopy.