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991.
A convenient and practical method for the synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines has been developed via a three-component, one-pot reaction from aldehydes, malononitrile and S-alkylisothiouronium salts in water at room temperature. A series of polysubstituted pyrimidines were prepared by this method in moderate to excellent yields. In addition, two kinds of pyrimidine-fused heterocyclic derivatives with potential pharmacological activity were constructed from our 2-alkylthio-4-amino-5-cyano-6-arylpyrimidines. 相似文献
992.
The residual Z(2)(s)(k) and Z(2)(s)(k) symmetries induce a direct and unique phenomenological relation with θx (≡ θ13) expressed in terms of the other two mixing angles θs(≡ θ12) and θa(≡ θ23) and the Dirac CP phase δD. Z(2)(s)(k) predicts a θx probability distribution centered around 3°-6° with an uncertainty of 2°-4°, while those from Z(2)(s)(k) are approximately a factor of 2 larger. Either result fits the T2K, MINOS, and Double Chooz measurements. Alternately, a prediction for the Dirac CP phase δD results in a peak at ± 74° (± 106°) for Z(2)(s)(k) or ± 123° (± 57°) for Z(2)(s)(k) which is consistent with the latest global fit. We also give a distribution for the leptonic Jarlskog invariant Jν which can provide further tests from measurements at T2K and NOνA. 相似文献
993.
The neural contrast sensitivity function (NCSF) of human eye at temporal frequencies is acquired with a new method in this paper. Firstly the human eye's contrast sensitivity function (CSF) at temporal frequencies is measured by means of travelling-wave stimuli, and the modulation transfer function (MTF) of the eye's optics is obtained by constructing the eye model of the subject. Then the NCSF at temporal frequencies is calculated with the two functions. It is shown that the overall value of the NCSF decreases as the temporal frequency increases. As the temporal frequency increases from 0 cycles per second (c/s) to 1 c/s, 16 c/s and 30 c/s, the NCSF curve changes from the band-pass shape to the low-pass, and then to almost monotonic variation. The attenuation factor of the NCSF, which represents the sensitivity of visual neural system to the temporal frequency, varies little as spatial frequency increases, while that of the CSF declines dramatically in the region of high spatial frequencies. Because it is the NCSF, rather than the CSF, that reflects the characteristics of visual neural system, the investigation of the NCSF at temporal frequency is more essentially. 相似文献
994.
995.
The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs) that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates. 相似文献
996.
Ge HX Zhang J Dong Y Cui K Yu BY 《Chemical communications (Cambridge, England)》2012,48(49):6127-6129
In this communication, we document a facile kinetic glycosylation resolution of racemic tetrahydroberberrubine. We also demonstrate that the enantiomeric excess of the resolved products is increased via a second resolution of the minor product of the first glycosylation resolution. This provides a rare example of tandem kinetic resolution of racemates. 相似文献
997.
X Mei S Yang D Chen N Li H Li Q Xu J Ge J Lu 《Chemical communications (Cambridge, England)》2012,48(80):10010-10012
Hollow mesoporous silica nanoparticles (HMSs) were modified by β-cyclodextrin via a "click" reaction, an amphiphilic copolymer with a trans-azobenzene structure was then assembled onto β-cyclodextrin to cover the surface of the HMSs. The prepared nanocomposites can release drugs in a "release-stop-release" manner by converting light irradiation. 相似文献
998.
A series of chiral pyrrolidine quaternary derivatives were designed and synthesized. It was found that these derivatives are highly efficient organocatalysts for the asymmetric Michael addition reactions of aldehydes and ketones to nitroolefins with high yields (up to 96%), high enantioselectivities (up to 99% ee), and high diastereoselectivities (up to 97:3 dr). Furthermore, catalyst 7a could be recycled without remarkable loss of catalytic activity and stereoselectivity. 相似文献
999.
Both ketone C-pyranosides (in up to 97% yields) and C-furanosides (in 83–97% yields) could be prepared, respectively, from the condensations of pentane-2,4-dione and various unprotected sugars in sodium carbonate aqueous media by adjusting the reaction conditions. 相似文献
1000.
As labor costs become more expensive, less labor-intensive disposable devices have become more ubiquitous. Similarly, the disposable optical pH sensor developed in our lab could provide a convenient yet cost-effective way for pH sensing in processes that require stringent pH control. This optical pH sensor is prepared in uniform individual lots of 100–200 sensors per lot. Calibration is accomplished on a few randomly selected sensors out of each lot. We show that all others in the same lot can then be used directly without requiring individual calibration. In this paper, a calibration model is derived to include all the factors that affect the signal of the disposable sensor. Experimental results show that the derived calibration model fits the experimental data. The readings of 28 randomly selected disposable sensors with 4 sensors from each of the 7 lots show an error less than 0.1 pH units in the useful sensing range of the sensor. The calibration model indicates that if further improvement on precision is desired, more uniform porous material and more advanced coating techniques will be required. When it comes to the effects of the varying coasters, house-made low-cost fluorometers, the variability in the brightness ratio of the blue-to-violet LEDs is the primary reason for the lack of precision. Other factors like LED light intensity distribution, optical properties of the filters and electronics also contribute to the coaster-to-coaster difference, but to a lesser extent. Two different methods for correcting the instrument variations were introduced. After correction, the collective reading errors for all the tested instruments were reduced to less than 0.2 pH units within the sensor's useful sensing range. Based on this result, our lab is currently implementing further improvements in modifying the coasters to equalize the ratios of blue-to-violet LED brightness. 相似文献