3,3,6,6-四甲基-9-邻氯苯基-1,8-二氧代-3,4,5,6,7,9-六氧化氧杂蒽的合成和晶体结构

标题化合物C23H25对O3Cl是由邻氯苯甲醛与5，5-二甲基1，3-环己二酮在N，N-二甲基甲酸腹中反应而得。结构通过单晶X-射线衍射法确定，其晶体属于单科晶系，空间群=1632。晶体结构用直接法解出，使用全矩阵最小二乘法对原子参数进行修正，最后的偏离因子为R=0．054，Rw一0．063。在晶体结构中，吡喃环与苯环之间的两面角为92．43°。     

芦荟大黄素的电化学研究

用单扫示波极谱法研究了芦荟大黄素的电化学行为。在５％Ｎａ２ＣＯ３＋５％ＮａＯＨ（９＋１）底液中，芦荟大黄素于－０．８４Ｖ（Ｐ１）和－０．９７Ｖ（Ｐ２）处产生两个示波极谱峰，利用Ｐ１可测定芦荟大黄素，线性范围为 ０．１１－２４ｍｇ／Ｌ和３．０－２８．６ｍｇ／Ｌ，检测限为０．０６ｍｇ／Ｌ。将该法应用于中药大黄中的芦荟大黄素的测定，结果满意。另外，讨论了芦荟大黄素清除由邻苯三酚自氧化产生的超氧自由基（Ｏ２）的作用。     

两种新型的分光光度法

介绍了两种新型的分光光度法:“正滴光度法”和“剩余光度法”。     

降铅冲剂对低水平铅暴露仔鼠血铅及脑铅的影响

目的:研究降铅冲剂对低水平铅暴露仔鼠血铅及脑铅的影响,为评价降铅冲剂的作用提供依据。方法:选用Wister大鼠仔鼠60只,体质量80~100 g,随机分成6组,每组10只,分别为空白组、模型对照组、EDTA对照组、降铅冲剂低剂量组、降铅冲剂中剂量组、降铅冲剂高剂量组;造模后开始给药,EDTA对照组给CaNa2EDTA注射液10(mg/kg)/d腹腔注射,降铅冲剂低、中、高剂量组分别予降铅冲剂5(g/kg)/d、10(g/kg)/d、20(g/kg)/d的剂量灌胃,空白组和模型对照组予等量蒸馏水灌胃,给药共30 d。用石墨炉原子吸收光谱仪测定仔鼠血铅、脑铅。结果:(1)染铅后,各染铅组的血铅水平与空白组比较都显著升高(P<0.001),经过30 d的治疗后,各治疗组的治疗后血铅水平均有不同程度下降,与模型对照组比较均有统计学意义。(2)染铅后,各染铅组的脑铅水平与空白组比较都显著升高(P<0.05),治疗后,各组脑铅与治疗前比较均显著升高,降铅冲剂低、中剂量组的脑铅与模型对照组比较显著下降。结论:降铅冲剂能显著降低低水平铅暴露仔鼠的血铅和脑铅含量,其综合疗效优于CaNa2EDTA。     

Preparation of HPMC–EA–DMAEMA nanosized latex

Nanosized copolymer latex of hydroxypropylmethylcellulose (HPMC) grafted with ethyl acrylate (EA) and dimethylaminoethyl methacrylate (DMAEMA) has been prepared by acidifying submicron-sized latex particles synthesized by soap-free emulsion graft copolymerization using potassium persulfate (KPS) as initiator. The effects on the diameter of the latex particles of different conditions, for example concentration of DMAEMA, amount of HPMC, and ratio of HCl to DMAEMA for acidification, were investigated. It was found that increasing the mole ratio of HCl to DMAEMA to 1.0 and increasing the DMAEMA content both resulted in a decrease in particle diameter, whereas increasing the amount of HPMC resulted in larger particle sizes. Measurement by dynamic light scattering (DLS) revealed the diameter of the latex particles was >200 nm before acidification and <100 nm after acidification. Evidence of grafting was obtained by use of Fourier transform infrared (FTIR) spectroscopy. Transmission electron microscopy (TEM) was used to characterize the morphology of the copolymer particles before and after acidification.     

Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins

The interactions of serum albumins such as human serum albumin (HSA) and bovine serum albumin (BSA) with emodin, rhein, aloe-emodin and aloin were assessed employing fluorescence quenching and absorption spectroscopic techniques. The results obtained revealed that there are relatively strong binding affinity for the four anthraquinones with HSA and BSA and the binding constants for the interactions of anthraquinones with HSA or BSA at 20 degrees C were obtained. Anthraquinone-albumin interactions were studied at different temperatures and in the presence of some metal ions. And the competition binding of anthraquinones with serum albumins was also discussed. The Stern-Volmer curves suggested that the quenching occurring in the reactions was the static quenching process. The binding distances and transfer efficiencies for each binding reactions were calculated according to the F?ster theory of non-radiation energy transfer. Using thermodynamic equations, the main action forces of these reactions were also obtained. The reasons of the different binding affinities for different anthraquinone-albumin reactions were probed from the point of view of molecular structures.     

Deposition of Layer－by－layer Inorganic－organic Nano－hybrid Ultrathin Films onto SBA－15

Deposition of inorganic-organic nano-hybrid ultrathin films onto mesoporous silicate materials has been proven possible by using layer-by-layer assembly method. In combination with sol-gel method, titania, subsequently dye molecules (or polymer) were successfully fabricated onto the inner wall of SBA-15. Their structures were preliminarily characterized by FTIR and solid-state UV-Vis spectroscopy, thermal analysis, and BET surface area measurements,respectively.     

甲烷—空气燃烧中NOx生成的简化模型研究

用特征值－特征向量法对甲烷－空气燃烧时ＮＯＸ生成的化学反应机理进行了简化，得到了仅由１５个基元以应组成的简化反应模型。对比计算结果表明，该模型能在较宽燃空比内与全面模型很好吻合，因而可望用于燃烧过程数值模拟时对ＮＯＸ生成的预测     

1-(α-萘乙酰基)-4-芳酰基氨基硫脲及3-(α-萘亚甲基)-4-芳酰基-1,2,4-三唑琳-5-硫酮的合成

许多酰氨基硫脲类衍生物有抗病毒、抗细菌、抗肿瘤等功效,我们曾经通过5-(α-萘)-2H-四唑-2-乙酰肼与芳酰异硫氰酸酯缩合得一系列新的酰氨基硫脲和相关的杂环衍生物,观察到它们在很低的浓度下就有调节小麦芽鞘生长的功能。Kothari等用α-萘乙酰肼与芳基异硫氰酸酯缩和制得一系列1-(α-萘乙酰基)-4-芳基氨基硫脲及