A Convenient Method for Synthesis Methyl Ester of Naproxen

α-Arylpropionic acids are a class of nonsteroidal anti-inflammatory drugs with a substantial size of market. Ibuprofen and naproxen are the important members of this family. Since carbonylation catalyzed by transition metal complexes provides an environmentally benign process for their synthesis, there have been numerous patents and publications related to the carbonylation of alcohols and olefins to produce α-arylpropionic acids or their esters^[1-4]. We have studied the carbonylation of α-(6'-methoxy-2'-naphthyl) ethanol to methyl ester of naproxen using PVP-PdCl₂-CuCl₂/PPh₃ catalyst system. Good conversion and selectivity were obtained under mild conditions.     

Racemization of R-Naproxen Ester Using Microwave Oven

(S)-(+)-2-(6-methoxy-2-naphthyl) propionic acid (Naproxen) is a nonsteroidal antiinflammatory drug which belongs to the family of 2-aryl propionic acid derivatives, which is widely used as a drug for human connective tissue diseases. The physiological activity of the S-form Naproxen is 28-fold that of the R-form^[1]. Hence, only the S-form is used as a drug for human diseases.     

关于离散型随机变量次序统计量分布矩阵对称性猜想的探索

本文研究了离散型随机变量次序统计量的分布矩阵的对称性 ,获得了二个定理 .定理 1　服从等概率二点分布或等概率三点分布的离散型随机变量的次序统计量的分布矩阵是对称矩阵 .定理 2　取值有限且等概率的离散型随机变量的次序统计量的分布矩阵具有中心对称性 .     

Accurate Burst Trigger Mode for Dragon-Ⅰ Electron Beam Measurement System

The electron beam measurement system for Dragon-I must work synchronously with the beam production and transportation accurately in order to obtain correct data．The synchronization with about 1ns is important．The output waveform of Blumlein lines in pulsed-power system is of amplitude of about 250kV and 20ns active edge time(following edge)．The electron beam will hit the conversion target in about 145ns later steadily and the jitter time is about 1—2ns．The synchronization precision with the same level of the jitter time will be reached if the sharp following edge of waveform is selected to be the time base．The synchronization trigger signal for measurement system can be obtained by the way of differentiating the following edge and the accuracy of about ns can also be reached with suitable circuit parameters．The optical fiber is also adopted to remove the interference on the measurement system from the high voltage system．This kind of burst trigger mode overcomes many disadvantages such as low accuracy, long delay time, large jitter in normal trigger mode and can provide the trigger time accurately．It can meet the need to measure the electron beam parameters at any required time．     

亲水型光敏热成像材料的化学增感

由于光敏热成像(Photothermographic,PTG)材料采用简单的干法(热)加工取代传统AgX成像材料的湿法加工,对环境友好且能耗低,可以实时实地的获得影像硬拷贝材料,可以广泛应用于医疗影像硬拷贝、航空拍摄等领域,因此PTG材料具有强大的发展潜力,是传统AgX成像材料的一种理想替代材料.     

[100]金刚石薄膜的辐照响应特性研究

采用热丝辅助化学气相沉积(HFCVD)方法生长得到25μm厚的[100]取向金刚石膜,用以制备辐射探测器.在100 V偏压下,测得暗电流为16.1 nA,55Fe X射线(5.9 keV)和241Am α粒子(5.5 MeV)辐照下的净光电流分别为15.9nA和7.0nA.光电流随时间的变化先快速增加随后由于"pumping"效应逐渐达到稳定.X射线和α粒子辐照下的平均电荷收集效率分别为45;和19;,并由Hecht理论计算得到对应的电荷收集距离为11.25μm和4.75μm.     

Cu(In,Ga)Se2薄膜电沉积制备及性能研究

采用Mo/钠钙玻璃衬底作为阴极,饱和甘汞电极(SCE)为参比电极,大面积的铂网电极作为阳极的三电极体系,以氯化铜,三氯化铟,三氯化镓和亚硒酸的水溶液为电解液,利用电沉积技术制备出黄铜矿结构Cu(In,Ga)Se2多晶薄膜.研究了不同热处理温度对CIGS多晶薄膜材料的组成、结构和表面形貌的影响以及薄膜的光电学性能.实验结果表明当热处理温度为450℃时,所制备的Cu(In,Ga)Se2薄膜的化学组成接近理想的化学计量比,薄膜具有黄铜矿结构,颗粒均匀,致密性较好,在室温下禁带宽度为1.43 eV,具有高的吸收系数.     

Unified Symmetry of Nonholonomic Mechanical Systems with Non-Chetaev＇s Type Constraints

Based on the total time derivative along the trajectory of the system, the unified symmetry of nonholonomic mechanical system with non-Chetaev＇s type constraints is studied. The definition and criterion of the unified symmetry of nonholonomic mechanical systems with non-Ohetaev＇s type constraints are given. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, is obtained. Two examples are given to illustrate the application of the results.     

银溶胶诱导多壁碳纳米管非共价表面修饰

利用银溶胶活化诱导淀粉螺旋结构实现了多壁碳纳米管非共价表面修饰. 实验结果表明, 淀粉非共价表面修饰的多壁碳纳米管在水中容易分散, 扫描电镜分析表明, 经银溶胶处理的多壁碳纳米管被单根分散在银溶胶溶液中. 酶解试验、IR和EDS分析表明, 碳纳米管表面修饰了一层淀粉.     

CdTe/CdS量子点的Ⅰ-Ⅱ型结构转变与荧光性质

制备了壳层厚度可以精确控制的CdTe/CdS核壳量子点, 利用紫外-可见吸收光谱、光致发光光谱、透射电镜和时间分辨光谱等技术, 分析了CdS壳层厚度对CdTe量子点的荧光量子产率和光谱结构的影响规律. 发现了不同于CdSe/CdS, CdSe/ZnS, CdTe/ZnS等核壳量子点的荧光峰展宽、大幅度红移以及荧光寿命大幅度增加现象. 根据能带的位置关系, 随着CdS厚度的增加, CdTe从Ⅰ型结构逐渐过渡到Ⅱ型核壳结构. 对于Ⅱ型CdTe/CdS核壳量子点, 不仅存在CdTe核区导带电子与价带空穴间的直接复合, 还存在CdS壳层导带电子与CdTe核价带空穴界面处的间接复合, 发光机制的变化导致荧光峰的展宽、明显红移和荧光寿命的增加. 当壳层过厚时, 壳层表面新引入的缺陷会阻碍荧光寿命和量子产率的进一步提高.