Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer

Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high‐performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC‐targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC.     

Optical waveguide double-ring sensor using intensity interrogation with a low-cost broadband source

A highly sensitive optical waveguide sensor based on simple intensity interrogation with a broadband light source is proposed and investigated. It consists of two cascaded microring resonators with the same or slightly different free spectral ranges. The variation of the refractive index of the analyte sample results in a large shift in the envelope function of the transmission peaks of the sensor, and, consequently, a large change in the transmitted power. The low-cost sensing scheme can achieve an ultrahigh sensitivity of 2 × 10? dB/RIU. Experimental results on the intensity interrogated double-ring sensor using a broadband source are presented, demonstrating its operation principle and potential for low-cost practical applications.     

Superheating of confined Pb thin films

In this work we report, for the first time, an experimental observation of a superheating phenomenon in metal thin films. By means of cold rolling, Pb thin films of about 20 nm thick were sandwiched by Al layers, and between them semicoherent epitaxial Pb/Al interfaces were formed. In situ x-ray diffraction analysis indicated that the confined Pb thin films could be superheated for at least 6 degrees C. Thermodynamic analysis indicated that such a substantial superheating in the confined two-dimensional thin films may originate from suppression of growth of the molten droplets by the epitaxial Al/Pb/Al confinement, instead of suppression of melt nucleation for the confined particle superheating.     

The structure and expression of power group

With the application of the topological upgrade, more and more experts are interested in the problems concerning the mathematical structure’s upgrade to its power set. This paper is a further study on the structure and interrelationship of a power group. By revealing the nature of relationship between the power group and a regular one, the present paper proves some theorems of the structure of the power group and constructs some theorems on its homomorphism and isomorphism as well, proposing an expression form and isomorphism replacement construct methods of the power group.     

Proportional and excess-of-loss reinsurance under investment gains

On the assumption that investment fund follows the logarithm-normal distribution, the paper derives the forms of proportional and excess-of-loss reinsurance contracts which make the convex combination of the insurer’s rate of return v₁ and the reinsurer’s rate of return v₂ exceeds R at the probability of f. In the whole paper, the premium takes the expectation principle.     

Coleman自同构群的投射极限

在这篇注记中,利用群的投射极限性质给出了有限可解群的Coleman自同构群的一个具体构造.作为应用,证明了二面体群的Coleman外自同构群或者是1或者是一个初等阿贝尔2-群.     

衰减相移掩模及其编码制作方法研究

在霍普金斯理论的基础上,对方孔的传统掩模、衰减相移以及加入光学邻近效应校正的衰减相移掩模在硅片表面光强分布的计算表明,衰减相掩模有提高光刻分辨率的显著功能,提出一种制作衰减相移掩模的编码方法。理论计算表明,该编码方法能够达到预定的衰减参数。     

A branch-and-bound algorithm to minimize the line length of a two-sided assembly line

A new branch-and-bound algorithm is presented to solve the two-sided assembly line balancing problem of type 1 (TALB-1). First, a pair of two directly facing station is defined as a position, and then the two-sided assembly line (TAL) is relaxed to a one-sided assembly line (OAL). Some new lower bound on positions are computed, and dominance rules and reduction rules for the one-sided assembly line balancing problem of type 1 (OALB-1) are extended and incorporated into a station-oriented assignment procedure for the TALB-1 problem. Finally, the tests are carried out on a well-known benchmark set of problem instances, and experimental results demonstrate that the proposed procedure is efficient.     

Inversion of Robin coefficient by a spectral stochastic finite element approach

This paper investigates a variational approach to the nonlinear stochastic inverse problem of probabilistically calibrating the Robin coefficient from boundary measurements for the steady-state heat conduction. The problem is formulated into an optimization problem, and mathematical properties relevant to its numerical computations are investigated. The spectral stochastic finite element method using polynomial chaos is utilized for the discretization of the optimization problem, and its convergence is analyzed. The nonlinear conjugate gradient method is derived for the optimization system. Numerical results for several two-dimensional problems are presented to illustrate the accuracy and efficiency of the stochastic finite element method.