Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014–present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1 , the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.     

Dynamic effect of constant inertial acceleration on vibration isolation system with high-order stiffness and Bouc–Wen hysteresis

Nonlinear Dynamics - Nonlinear vibration isolation provides with an effective way for vibration reduction with broad band and high efficiency. This investigation focuses on the dynamic effects of a...     

General Formation of Macro-/Mesoporous Nanoshells from Interfacial Assembly of Irregular Mesostructured Nanounits

Mesoporous core–shell nanostructures with controllable ultra-large open channels in their nanoshells are of great interest. However, soft template-directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous range, remains a significant challenge. Herein we report a general approach for precisely tailored coating of hierarchically macro-/mesoporous polymer and carbon shells, possessing highly accessible radial channels with extremely wide pore size distribution from ca. 10 nm to ca. 200 nm, on diverse functional materials. This strategy creates opportunities to tailor the interfacial assembly of irregular mesostructured nanounits on core materials and generate various core–shell nanomaterials with controllable pore architectures. The obtained Fe,N-doped macro-/mesoporous carbon nanoshells show enhanced electrochemical performance for the oxygen reduction reaction in alkaline condition.     

Numerical Evaluation of a Two-Loop Diagram in the Cutoff Regularization

The sunset diagram of λφ4 theory is evaluated numerically in cutoff scheme and a nonzero finite term(in accordance with dimensional regularization (DR) result) is found in contrast to published calculations. This findingdramatically reduces the critical couplings for symmetry breaking in the two-loop effective potential discussed in ourprevious work.     

<Emphasis Type="Italic">FCC/BCC</Emphasis> competition and enhancement of saturation magnetization in nanocrystalline Co-Ni-Fe films

The structure, chemical composition, and magnetic properties of electrochemically deposited nanocrystalline Co-Ni-Fe films were investigated using a number of techniques. A high saturation magnetic induction up to B _s = 21 kG was attained. An enhancement of the saturation magnetization compared to the ideal anticipated one was revealed, which correlated with the nonlinear behavior of the structural phase composition and lattice parameters with the change of the composition. The text was submitted by the authors in English.     

ON A PAIR OF NON-ISOMETRIC ISOSPECTRAL DOMAINS WITH FRACTAL BOUNDARIES AND THE WEYL-BERRY CONJECTURE

ＯＮＡＰＡＩＲＯＦＮＯＮＩＳＯＭＥＴＲＩＣＩＳＯＳＰＥＣＴＲＡＬＤＯＭＡＩＮＳＷＩＴＨＦＲＡＣＴＡＬＢＯＵＮＤＡＲＩＥＳＡＮＤＴＨＥＷＥＹＬＢＥＲＲＹＣＯＮＪＥＣＴＵＲＥＳＬＥＥＭＡＮ，Ｂ．Ｄ．ＣＨＥＮＨＵＡＭａｎｕｓｃｒｉｐｔｒｅｃ...     

从培养能力的角度看设计性实验

针对传统实验那种安排过死、刻板机械的特点，把设计性实验运用于教具设计与制作课程之中，充分地培养了学生动手、动脑的综合能力。