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41.
We study the structure and dynamics of hydrogen-bonded complexes of H2O/D2O and dimethyl sulfoxide (DMSO) by infrared spectroscopy, NMR spectroscopy and ab initio calculations. We find that single water molecules occur in two configurations. For one half of the water monomers both OH/OD groups form strong hydrogen bonds to DMSO molecules, whereas for the other half only one of the two OH/OD groups is hydrogen-bonded to a solvent molecule. The H-bond strength between water and DMSO is in the order of that in bulk water. NMR deuteron relaxation rates and calculated deuteron quadrupole coupling constants yield rotational correlation times of water. The molecular reorientation of water monomers in DMSO is two-and-a-half times slower than in bulk water. This result can be explained by local structure behavior. 相似文献
42.
Distinctive Molecular Abnormalities in Benign and Malignant Skin Lesions: Studies by Raman Spectroscopy 总被引:6,自引:0,他引:6
Monika Gniadecka Hans C. Wulf Ole F. Nielsen Daniel H. Christensen Jana Hercogova 《Photochemistry and photobiology》1997,66(4):418-423
Abstract— Near-infrared Fourier transform Raman spectroscopy is an analytical, nondestructive technique that provides information about the molecular structure of the investigated sample. The molecular structure of proteins and lipids differs between neoplastic and normal tissues and therefore Raman spectroscopy has been considered promising for the diagnosis of cancer. We aimed to compare the molecular structure of normal skin, benign and malignant skin lesions by the near-infrared Fourier transform Raman spectroscopy. Biopsies were obtained from the following skin lesions: skin tag, dermatofibroma, seborrhoeic keratosis, actinic keratosis, keratoacan-thoma, basal cell carcinoma, squamous cell carcinoma, nevus intradermal, nevus compositus, dysplastic nevus and lentigo maligna. Control skin was harvested from the vicinity of these lesions. In the Raman spectra, the secondary structure of the proteins was reflected by the amide vibrations of peptide bonds. The principal lipid vibrations were twisting and wagging (CH2 ) and CH stretching vibrations. Histologically distinguishable lesions showed specific combinations of band changes indicating alterations in the protein conformation and in the molecular structure of the lipids. Histogenetically related lesions (actinic keratosis and sqamous cell carcinoma) produced similar but not identical patterns of spectral changes. Because the examined skin lesions produced reproducible and unique spectra, we suggest that Raman spectroscopy will be useful for diagnosis of skin lesions. 相似文献
43.
Validation and application of an LC-MS/MS method for the simultaneous quantification of 13 pharmaceuticals in seawater 总被引:2,自引:0,他引:2
Klaas Wille Herlinde Noppe Karolien Verheyden Julie Vanden Bussche Eric De Wulf Peter Van Caeter Colin R. Janssen Hubert F. De Brabander Lynn Vanhaecke 《Analytical and bioanalytical chemistry》2010,397(5):1797-1808
Knowledge of the presence of micropollutants such as pharmaceuticals, in coastal areas, is very limited; therefore, the main
objective of this study was to optimize and validate a new analytical method for the quantitative analysis of 13 multiclass
pharmaceuticals in seawater. Target compounds included antibiotics, non-steroidal anti-inflammatory drugs, β-blockers, lipid
regulators and one psychiatric drug. A combination of solid-phase extraction and liquid chromatography coupled with multiple
mass spectrometry enabled their detection at the low nanogram per litre level. The limits of quantification varied between
1 and 50 ng L-1, for most components the linearities were more than 0.99 and the recoveries obtained in seawater (95–108%) were satisfactory.
This method was applied to seawater and estuarine water samples collected in the Belgian coastal zone, to assess the prevalence
of common pharmaceuticals in this marine environment. Seven pharmaceuticals, including compounds of which the presence in
marine environments had not been reported earlier, were detected, with salicylic acid and carbamazepine being the most abundant,
in concentrations up to 855 ng L-1. 相似文献
44.
Krivovichev SV Siidra OI Nazarchuk EV Burns PC Depmeier W 《Inorganic chemistry》2006,45(10):3846-3848
Dark-green platy crystals of the new compound Pb31O22Br10Cl8 (1) have been obtained by rapid quenching of a lead oxide halide melt. The structure of 1 (triclinic, P1, a = 12.1192(7) angstroms, b = 16.2489(10) angstroms, c = 18.3007(11) angstroms, alpha = 93.104(2) degrees, beta = 95.809(2) degrees, gamma = 111.252(1) degrees, V = 3325.4(3) angstroms3, Z = 2) can be viewed as incorporation of [PbX6]4- halide units (X = Br, Cl) into the defect PbO matrix. The latter represents a two-dimensional [O22Pb30]16+ cationic layer of OPb4 tetrahedra that can be derived from the [OPb] tetrahedral layer observed in tetragonal PbO. The layer consists of 22 symmetrically inequivalent OPb4 tetrahedra and represents the topologically most complicated arrangement of tetrahedra known to date. 相似文献
45.
The PUR-fiber-spray molding technology is a manufacturing process which produces polyurethane-based (PUR) composites by spraying the matrix together with reinforcing fibers in a tool form or on a substrate. Thereby chopped fibers are laterally (sidewise) injected in the polyurethane-air spray cone for wetting before the entire composite is spread on the substrate, where it starts curing. To investigate and compute the fiber orientation and density distribution in the final composites manufactured by this process, a new approach simplifying the multiply coupled interaction of the three phases is presented in this paper. Hereby it is presumed that the final position and orientation of a fiber on a substrate results from its dynamics and coupled interactions with air, PUR-droplets and other fibers within the spray cone. Thus, a model of the process is built, that computes the transient behavior of the air-liquid droplets mixture by the CFD code ANSYS Fluent and its influence on the dynamics of the fibers by an extra code called FIDYST. For this multiphase problem two approaches are presented for the droplet-fiber coupling using a concept called “homogenization” of the liquid phase (droplets in the continuous phase). (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
46.
47.
de Fine Olivarius F Wulf HC Crosby J Norval M 《Journal of photochemistry and photobiology. B, Biology》1999,48(1):42-47
Exposure to ultraviolet (UV) radiation may induce erythema, DNA damage and suppression of immune responses. Melanin pigmentation offers protection against the first two of these effects, but immunosuppression seems to occur irrespective of the subject's pigmentation. Cis-urocanic acid (cis-UCA), produced by isomerization of trans-UCA in the stratum corneum on UV exposure, initiates some of the immunomodulatory effects of UV radiation. In the present study the relationship between skin pigmentation and UCA isomerization has been examined in 28 healthy individuals of skin types I-IV. Pigmentation is measured in five areas of not recently exposed back skin before irradiation with 0, 0.45, 0.9, 1.8 and 3.6 standard erythema dose (SED) of filtered broadband UV-B (1 SED = 10 mJ cm-2 at 298 nm). The concentration of UCA isomers is measured immediately after the irradiation. With 3.6 SED, the relative production of cis-UCA is close to the maximum obtainable, irrespective of skin type. A significant negative correlation is found between pigmentation and relative production of cis-UCA at 0.45 and 1.8 SED, and between pigmentation and absolute production of cis-UCA at 0.45 SED. At doses of 0.45 and 0.9 SED the relative and absolute production of cis-UCA are higher in the group with skin types I and II when compared with the group with skin types III and IV. The higher isomerization in the lightly pigmented subjects than in the more pigmented ones may indicate that people with fair skin are at a relatively higher risk of immunosuppression when exposed to low doses of UV radiation. 相似文献
48.
Schröder D Schwarz H Wulf M Sievers H Jutzi P Reiher M 《Angewandte Chemie (International ed. in English)》1999,38(23):3513-3515
High-energy collisions of Cp*P(6)(+) cations yield neutral P(6) molecules (see reaction), thus providing the first experimental evidence for the existence of this new allotrope of phosphorus. 相似文献
49.
The application of a combined gas chromatography-combustion/isotope ratio mass spectrometry (GC-C/IRMS) method for stable carbon isotope analysis of amino acid enantiomers in soil samples is presented. Triplicate delta(13)C analyses of pentafluoropropionyl (PFP) isopropyl ester derivatives of 27 amino acid enantiomers revealed that discrimination of (13)C during derivatization is different for different amino acid enantiomers and different amounts. Injection of increasing amounts of amino acid derivatives showed that the isotopic signal varied up to 10 per thousand for D-aspartic acid. Correction for the delta(13)C signal of underivatized amino acid enantiomers is possible for all investigated amino acid enantiomers using logarithmic functions. Operating the GC-C/IRMS system in the split-mode (split ratio 1:12) is possible but resulted in a higher isotopic discrimination. The detection limit approached 3 ng for some amino acid enantiomers in the splitless mode, while the lower limit of routine determination exceeded 10 ng injection amount. The upper limit at which accurate stable isotope values were obtained was 200 ng injection amount. Compound-specific delta(13)C analysis of alanine, valine, aspartic and glutamic acid showed that the D-forms were enriched in (13)C relative to the L-forms, suggesting that microbes significantly contributed to the formation of the D-enantiomers in soil. 相似文献
50.
Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase–Inhibitor Complex