A new strategy for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system and its application to the efficient synthesis of BMS-238497, a novel and potent Lck inhibitor

A new efficient strategy was developed for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system. The new method involves condensation of o-nitroaniline with glyoxylate in methanol followed by treatment of the resulting alpha-(o-nitroanilino)-alpha-methoxy acetate with tosylmethyl isocyanide (TosMIC) reagent to give 1-(o-nitrophenyl)imidazole-5-carboxylate. Reductive cyclization of the nitro imidazole carboxylate afforded imidazo[1,5-a]quinoxalin-4-one in three steps and 60% overall yield. The new method was successfully applied to the synthesis of BMS-238497, a novel and potent Lck inhibitor.     

激光诱导击穿光谱(LIBS)法微损快速检测党参中Pb

中药材重金属元素快速检测对污染监控及人们健康具有重要意义。激光诱导击穿光谱技术(Laser Induced Breakdown Spectroscopy, LIBS)属于一种快速检测方法,研磨压片等预处理方法相对样品消解已有所简化,但破坏了样品的物理性质,且不能满足中药材大宗品种、大批量检测需求。若进一步简化样品预处理,将更加凸显LIBS快速检测的优势。本文建立了激光诱导击穿光谱技术(LIBS)快速微损检测中药材样品重金属元素定标方法。线性相关系数R2为0.7764,建立的微损定标曲线线性可用于切片党参LIBS快速检测,对待测党参切片样品检测平均相对误差为3.74%,与电感耦合等离子体质谱法(ICP-MS)对比,相关系数R2为0.7957,验证了LIBS技术微损检测的可行性。制备的党参参考定标样品可多次重复用于待测样定标和仪器标定等。实验对待测党参样品仅进行切片处理,避免了研磨、压片等预处理,更加充分地体现LIBS快速检测的优势,为LIBS技术应用于中药材重金属元素快检等领域提供了一种新方法。     

X射线荧光光谱(XRF)法测定绿泥石中镁、铝、硅、磷、钾、钙、钛、铁元素含量

建立了X射线荧光光谱法测定绿泥石中镁、铝、硅、磷、钾、钙、钛、铁元素含量的快速分析方法。以标准物质及标准物质与基准试剂氧化镁、氧化钙人工混合配制标样的方法建立标准工作曲线,重点讨论了熔剂和脱模剂的选取。最佳熔样条件：采用8.0g四硼酸锂和偏硼酸锂混合熔剂(质量比67: 33)+0.8g样品并添加溴化锂作为脱模剂,熔样温度1100℃,熔样时间10min。该方法相对标准偏差(n=12)均小于5.57%,绿泥石样品测定结果与化学法一致,硅酸盐标准物质测定结果均满足不确定度要求。     

Complete Cohomology for Extriangulated Categories

Let (C,E,s) be an extriangulated category with a proper class ξ of E-triangles.We study complete cohomology of objects in (C,E,s) by applying ξ-projective resolutions and ξ-injective coresolutions constructed in (C,E,s).Vanishing of complete cohomology detects objects with finite ξ-projective dimension and finite ξ-injective dimension.As a consequence,we obtain some criteria for the validity of the Wakamatsu tilting conjecture and give a necessary and sufficient condition for a virtually Gorenstein algebra to be Gorenstein.Moreover,we give a general technique for computing complete cohomology of objects with finite ξ-Gprojective dimension.As an application,the relations between ξ-projective dimension and ξ-Gprojective dimension for objects in (C,E,s) are given.     

Speckle characteristics of simulated deep Fresnel region under shadowing effect

After the three-dimensional self-affine fractal random surface simulation, we use the optical scattering theory to calculate the deep Fresnel region speckle(DFRS) under consideration of the more strict shadowing effect. The evolution of DFRS with the scattering distance and the intensity probability distribution are studied. It is found that the morphology of the scatterer has an antisymmetric relationship with the intensity distribution of DFRS, and the effect of micro-lenses on the scattering surface causes the intensity probability distribution of DFRS to deviate from the Gaussian speckle in the high light intensity area.     

Quantum-Inspired Complex-Valued Language Models for Aspect-Based Sentiment Classification

Aiming at classifying the polarities over aspects, aspect-based sentiment analysis (ABSA) is a fine-grained task of sentiment analysis. The vector representations of current models are generally constrained to real values. Based on mathematical formulations of quantum theory, quantum language models have drawn increasing attention. Words in such models can be projected as physical particles in quantum systems, and naturally represented by representation-rich complex-valued vectors in a Hilbert Space, rather than real-valued ones. In this paper, the Hilbert Space representation for ABSA models is investigated and the complexification of three strong real-valued baselines are constructed. Experimental results demonstrate the effectiveness of complexification and the outperformance of our complex-valued models, illustrating that the complex-valued embedding can carry additional information beyond the real embedding. Especially, a complex-valued RoBERTa model outperforms or approaches the previous state-of-the-art on three standard benchmarking datasets.     

Joint Optimization of Control Strategy and Energy Consumption for Energy Harvesting WSAN

With the rapid development of wireless sensor technology, recent progress in wireless sensor and actuator networks (WSANs) with energy harvesting provide the possibility for various real-time applications. Meanwhile, extensive research activities are carried out in the fields of efficient energy allocation and control strategy design. However, the joint design considering physical plant control, energy harvesting, and consumption is rarely concerned in existing works. In this paper, in order to enhance system control stability and promote quality of service for the WSAN energy efficiency, a novel three-step joint optimization algorithm is proposed through control strategy and energy management analysis. First, the optimal sampling interval can be obtained based on energy harvesting, consumption, and remaining conditions. Then, the control gain for each sampling interval is derived by using a backward iteration. Finally, the optimal control strategy is determined as a linear function of the current plant states and previous control strategies. The application of UAV formation flight system demonstrates that better system performance and control stability can be achieved by the proposed joint optimization design for all poor, sufficient, and general energy harvesting scenarios.     

Sending-or-Not-Sending Twin-Field Quantum Key Distribution with a Passive Decoy-State Method

Twin-field quantum key distribution (TF-QKD) has attracted considerable attention because it can exceed the basic rate-distance limit without quantum repeaters. Its variant protocol, sending or not-sending quantum key distribution (SNS-QKD), not only fixes the security vulnerability of TF-QKD, but also can tolerate large misalignment errors. However, the current SNS-QKD protocol is based on the active decoy-state method, which may lead to side channel information leakage when multiple light intensities are modulated in practice. In this work, we propose a passive decoy-state SNS-QKD protocol to further enhance the security of SNS-QKD. Numerical simulation results show that the protocol not only improves the security in source, but also retains the advantages of tolerating large misalignment errors. Therefore, it may provide further guidance for the practical application of SNS-QKD.     

Aqueous electrochemically-triggered atom transfer radical polymerization

Simplified electrochemical atom transfer radical polymerization (seATRP) using Cu^II–N-propyl pyridineimine complexes (Cu^II(NPPI)₂) is reported for the first time. In aqueous solution, using oligo(ethylene glycol) methyl ether methacrylate (OEGMA), standard electrolysis conditions yield POEGMA with good control over molecular weight distribution (Đ_m < 1.35). Interestingly, the polymerizations are not under complete electrochemical control, as monomer conversion continues when electrolysis is halted. Alternatively, it is shown that the extent and rate of polymerization depends upon an initial period of electrolysis. Thus, it is proposed that seATRP using Cu^II(NPPI)₂ follows an electrochemically-triggered, rather than electrochemically mediated, ATRP mechanism, which distinguishes them from other Cu^IIL complexes that have been previously reported in the literature.

Simplified electrochemical atom transfer radical polymerization (seATRP) using Cu^II-pyridineimine complexes is reported and follows a previously unreported electrochemically triggered mechanism.