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41.
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The “relaxation” procedure introduced by Held and Karp for approximately solving a large linear programming problem related to the traveling-salesman problem is refined and studied experimentally on several classes of specially structured large-scale linear programming problems, and results on the use of the procedure for obtaining exact solutions are given. It is concluded that the method shows promise for large-scale linear programming 相似文献
43.
The buildup of a large long-lived electron-hole drop in stressed Ge is studied using its Alfvén wave resonances. This microwave method permits rapid time resolution of the formation process after a short intense (100 nsec, 7 W) laser excitation pulse. A delay of about 1 μsec is observed before the drop radius rapidly increases from zero to ~ 100 μm within the next μsec. This is consistent with the interpretation that the photo-produced electron-hole pairs are quickly accelerated to the strain-induced potential minimum which is well within the crystal. 相似文献
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C.G. Cassapakis H.C. Bryant B.D. Dieterle C.P. Leavitt D.M. Wolfe B.E. Bonner J.E. Simmons C.W. Bjork P.J. Riley M.L. Evans G. Glass J.C. Hiebert M. Jain R.A. Kenefick L.C. Northcliffe D.W. Werren 《Physics letters. [Part B]》1976,63(1):35-38
The measured cross sections show a narrow high-energy peak (20–30 MeV/cFWHM) and a broad bump at lower momenta associated with pion production. Comparison is made to an intranuclear cascade calculation. 相似文献
46.
Philip Wolfe 《Mathematical Programming》1974,7(1):380-383
An algorithm is described for finding the minimum of any convex, not necessarily differentiable, functionf of several variables. The algorithm yields a sequence of points tending to the solution of the problem, if any; it requires the calculation off and one subgradient off at designated points. Its rate of convergence is estimated for convex and also for twice differentiable convex functions. It is an extension of the method of conjugate gradients, and terminates whenf is quadratic.
Editor's note. The communications of Wolfe and Lemarechal which follow — received almost simultaneously — display different points of view, but deal with the same problem and use similar techniques. They are preliminary versions of promising attacks on the problem of minimizing a convex, but not necessarily differentiable, function of many variables. MATHEMATICAL PROGRAMMING STUDY 3 entitledNondifferentiable optimization is to be devoted to this subject. 相似文献
47.
The amphoteric behavior of Sn, a commonly-used dopant in AsCl3GaH2 vapor epitaxy, is examined for Sn concentration from 5 × 1014 to 5 × 1017cm?3. The compensation ratio remains constant at 0.23 for low concentrations and begins to increase in the 1016cm?3 range. This behavior can be explained quantitatively with non-equilibrium impurity incorporation model which takes into account 3 × 1011 cm?2 surface states. 相似文献
48.
Abouzaid E Arenton M Barker AR Bellantoni L Bellavance A Blucher E Bock GJ Cheu E Coleman R Corcoran MD Cox B Erwin AR Escobar CO Glazov A Golossanov A Gomes RA Gouffon P Hsiung YB Jensen DA Kessler R Kotera K Ledovskoy A McBride PL Monnier E Nguyen H Niclasen R Ii DG Ping H Ramberg EJ Ray RE Ronquest M Santos E Slater W Smith D Solomey N Swallow EC Toale PA Tschirhart R Wah YW Wang J White HB Whitmore J Wilking MJ Winstein B Winston R Wolfe C Worcester ET Worcester M Yamanaka T Zimmerman ED 《Physical review letters》2008,100(13):131803
The Fermilab KTeV experiment has searched for lepton-flavor-violating decays of the K(L) meson in three decay modes. We observe no events in the signal region for any of the modes studied, and we set the following upper limits for their branching ratios at the 90% C.L.: BR(K(L) --> pi(0) micro(+/-) e(-/+)) <7.6 x 10(-11); BR(K(L) --> pi(0)pi(0) micro(+/-) e(-/+)) <1.7 x 10(-10); BR(pi(0) --> micro(+/-) e(-/+)) <3.6 x 10(-10). This result represents a factor of 82 improvement in the branching ratio limit for K(L) --> pi(0) micro(+/-) e(-/+) and is the first reported limit for K(L) --> pi(0)pi(0) micro(+/-) e(-/+). 相似文献
49.
Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides
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Justin M. Wolfe Colin M. Fadzen Rebecca L. Holden Monica Yao Gunnar J. Hanson Prof. Bradley L. Pentelute 《Angewandte Chemie (International ed. in English)》2018,57(17):4756-4759
Exon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the nucleus. While cell‐penetrating peptides can improve delivery, proteolytic instability often limits efficacy. It is hypothesized that the bicyclization of arginine‐rich peptides would improve their stability and their ability to deliver oligonucleotides into the nucleus. Two methods were introduced for the synthesis of arginine‐rich bicyclic peptides using cysteine perfluoroarylation chemistry. Then, the bicyclic peptides were covalently linked to a phosphorodiamidate morpholino oligonucleotide (PMO) and assayed for exon skipping activity. The perfluoroaryl cyclic and bicyclic peptides improved PMO activity roughly 14‐fold over the unconjugated PMO. The bicyclic peptides exhibited increased proteolytic stability relative to the monocycle, demonstrating that perfluoroaryl bicyclic peptides are potent and stable delivery agents. 相似文献
50.
Resonances and/or singularities during measurement and calibration often limit the precision of acoustic impedance spectra. This paper reviews and compares several established techniques, and describes a technique that incorporates three features that considerably improve precision. The first feature is to minimize problems due to resonances by calibrating the instrument using up to three different acoustic reference impedances that do not themselves exhibit resonances. The second involves using multiple pressure transducers to reduce the effects of measurement singularities. The third involves iteratively tailoring the spectrum of the stimulus signal to control the distribution of errors across the particular measured impedance spectrum. Examples are given of the performance of the technique on simple cylindrical waveguides. 相似文献