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71.
Carlos Camacho‐Camacho Monique Biesemans Ingrid Verbruggen Rudolph Willem 《应用有机金属化学》2005,19(3):343-346
The reactivity and catalytic potential of the tin salicylaldoximate cluster [(Me2Sn)2(Me2SnO)(OCH3) (HONZO)(ONZO)] ( 1 ), with HONZOH = o‐HON?CH? C6H4OH, on the acylation reaction of various alcohols with ethyl acetate is reported. The catalyst is active toward primary and unhindered secondary alcohols, but inefficient toward tertiary and secondary bulky alcohols and phenols. A possible mechanism for the transesterification reaction catalyzed by 1 , accounting for the influence of steric factors, is proposed. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
72.
73.
This paper is devoted to the existence of positive solutions of a Dirichlet problem with critical exponent and a singular potential. Under various assumption on the domain Ω, which include some kinds of unbounded domains, we prove the existence of ground states and of symmetric solutions. 相似文献
74.
In this note, a limiting technique is presented to enforcemonotonicity for higher-order spatial diffusion discretizations.The aim is to avoid spurious oscillations and to improve thequalitative behaviour on coarse grids. The technique is relatedto known ones for convection equations, using limiters to boundthe numerical fluxes. Applications arise in pattern formationproblems for reactiondiffusion equations. 相似文献
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76.
When can one see from the spectrum of a graph whether it is distance-regular or not? We give some new results for when this is the case. As a consequence we find (among others) that the following distance-regular graphs are uniquely determined by their spectrum: The collinearity graphs of the generalized octagons of order (2,1), (3,1) and (4,1), the Biggs-Smith graph, the M 22 graph, and the coset graphs of the doubly truncated binary Golay code and the extended ternary Golay code. 相似文献
77.
We have experimentally studied the distribution of the spatial extent of modes and the crossover from essentially single-mode to distinctly multimode behavior inside a porous gallium phosphide random laser. This system serves as a paragon for random lasers due to its exemplary high index contrast. In the multimode regime, we observed mode competition. We have measured the distribution of spectral mode spacings in our emission spectra and found level repulsion that is well described by the Gaussian orthogonal ensemble of random-matrix theory. 相似文献
78.
79.
Light‐Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy
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Dr. Wiktor Szymanski Maria E. Ourailidou Dr. Willem A. Velema Prof. Dr. Frank J. Dekker Prof. Dr. Ben L. Feringa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(46):16517-16524
Cancer treatment suffers from limitations that have a major impact on the patient’s quality of life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs reduces their efficacy and causes severe side effects due to nonselective toxicity. Photopharmacology allows a novel approach to address these problems because it employs external, local activation of chemotherapeutic agents by using light. The development of photoswitchable histone deacetylase (HDAC) inhibitors as potential antitumor agents is reported herein. Analogues of the clinically used chemotherapeutic agents vorinostat, panobinostat, and belinostat were designed with a photoswitchable azobenzene moiety incorporated into their structure. The most promising compound exhibits high inhibitory potency in the thermodynamically less stable cis form and a significantly lower activity for the trans form, both in terms of HDAC activity and proliferation of HeLa cells. This approach offers a clear prospect towards local photoactivation of HDAC inhibition to avoid severe side effects in chemotherapy. 相似文献
80.
Shestakova P Willem R Vassileva E 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(52):14867-14877
(1)H HRMAS NMR spectroscopy is applied to gain insight into the chemical and morphological structure of double-network (DN) hydrogels, prepared from poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) and poly(acrylamide) (PAAm). The method enables one to obtain detailed information at the molecular level about the formation of covalent bonds between the two polymer networks through non-reacted double bonds of the cross-linker N,N'-methylene bis(acrylamide) (MBAA). Evidence to the existence of strong hydrogen-bond interactions based on the N-H group of the PAMPS as a hydrogen-bond donor and the C=O group of the PAAm as a hydrogen-bond acceptor is also provided. These findings clarify the origin of the toughening mechanism and the exceptionally strong mechanical properties of DN gels, further supported by microhardness data. 相似文献