MOCVD过程中金属有机源(C~3H~7)~2Te和(CH~3)~2Cd热裂解机理 质谱实时研究

采用质谱技术实时研究了金属有机源DIPTe和DMCd在MOCVD反应器中热裂解的性质。着重分析了可能发生的气相反应及热裂解机理,并探讨了在CdTe,HgCdTe实际生长条件下两个有机源之间可能发生的相互作用及其对热裂解温度的影响。     

氯磺酚s与铝的显色反应及其应用的研究

本文较详细地研究了表面活性剂和有机溶剂存在下,氯磺酚s与铝的显色反应.试验表明:适量Triton X-10。和丙酮对此反应有协同增敏作用,且选择性亦较好.应用铝一抓磺酚S-Triton X-100一丙酮体系,测定了在铝制炊具中煮沸过的水中的铝.     

非离子表面活性剂胶束增溶显色反应机理的研究(Ⅱ)——非离子表面活性剂对Me2+-PAN的作用及其增溶萃取公式

本文以分光光度法研究了在TritonX-100胶束存在下,若干二价金属离子(Me²⁺)与1-(2-吡啶偶氮)-2-茶酚(PAN)的络合反应。导出了用聚氧乙烯型非离子表面活性剂增溶萃取Me²⁺-PAN螯合物的通式,并指出了利用此公式发生偏差的原因。     

土壤中多氯联苯成分分析标准物质的研制与定值

介绍了土壤中多氯联苯成分分析标准物质研制与定值方法。土壤采自我国东部某变压器油污染地区,经过风干、研磨、筛分、烘干和混匀后加工处理并装1000瓶。随机抽取20瓶做瓶间均匀性检验;随机抽取两瓶,每瓶取5份,做瓶内均匀性检验。分析测试结果经过F检验和t检验,在95%置信区间内。经过一年时间-18℃和20℃稳定性检验,分析测试结果经过t检验在95%置信区间内。标准物质利用同位素稀释质谱法对14种共平面和指示性多氯联苯同类物定值,并经过4个实验室进行试用,进一步验证了定值的准确性。此标准物质于2006年3月通过国家一级标准物质的终审。本实验所提出的有机污染物标准物质的制备方法,对在我国开展环境分析质控产品的研制具有参考和借鉴价值。     

Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies

The growing prevalence of antimicrobial drug resistance in pathogenic bacteria is a critical threat to global health. Conventional antibiotics still play a crucial role in treating bacterial infections, but the emergence and spread of antibiotic-resistant micro-organisms are rapidly eroding their usefulness. Cationic polymers, which target bacterial membranes, are thought to be the last frontier in antibacterial development. This class of molecules possesses several advantages including a low propensity for emergence of resistance and rapid bactericidal effect. This review surveys the structure–activity of advanced antimicrobial cationic polymers, including poly(α-amino acids), β-peptides, polycarbonates, star polymers and main-chain cationic polymers, with low toxicity and high selectivity to potentially become useful for real applications. Their uses as potentiating adjuvants to overcome bacterial membrane-related resistance mechanisms and as antibiofilm agents are also covered. The review is intended to provide valuable information for design and development of cationic polymers as antimicrobial and antibiofilm agents for translational applications.

This review surveys the structure–activity of advanced antimicrobial cationic polymers with low toxicity and high selectivity. Their uses as potentiating adjuvants and as antibiofilm agents are also covered.     

高亮度掺杂红色有机电致发光器件的制备与光电性能研究

采用真空热蒸镀的方法,在高精度膜厚控制仪监控下,实现了有机薄膜功能材料的精确蒸镀,其中发光层采用主体材料与掺杂材料在一个真空腔体同时共同蒸发,制备了一种高亮度多层结构的红色有机电致发光(OLED)器件:ITO-CuPc(20 nm)--αNPD(60 nm)-Alq3(40 nm)∶Rubrene(10%)∶DCJTB(1%)-Alq3(20 nm)-LiF(10 nm)-Al(100 nm)。研究发现:驱动在电压为5~52 V变化时,其亮度基本满足线性增加关系,随之饱和;随着驱动电压的变化,其电致发光光谱有蓝移的现象,发射峰从638 nm变到632 nm,同时色坐标CIEx,y值也发生相应的变化;器件的流明效率在驱动电压较低时(V=5 V),达到最大值ηLmax=0.497 lm.W-1,随着驱动电压的增加,流明效率有降低的趋势。     

三温方程中的电子-辐射能量交换项的计算

讨论了激光靶耦合数值模拟中电子-辐射能量交换项的处理。为了克服它给三温方程求解带来的困难,在非平衡区(T_e>T_r)和接近平衡区(T_e~T_r)采用了不同的能量交换项形式。此外,由于接近平衡时的能量交换项用辐射平均自由程表示,避免了此时计算束缚电子占据概率不准确的问题。     

基于反向撞击法的JB-9014炸药Hugoniot关系测量

为了获得JB-9014未反应炸药的Hugoniot关系,在火炮加载平台上利用反向撞击技术对JB-9014炸药进行一维平面冲击实验。将JB-9014炸药样品作为飞片安装于弹托前表面,将镀膜氟化锂窗口作为装置靶。利用火炮加速弹托,使炸药样品以一定速度撞击镀膜氟化锂窗口,通过光子多普勒测速仪(photonic Doppler velocimetry,PDV)测量炸药样品击靶速度以及炸药/镀膜氟化锂窗口界面粒子速度。最终根据冲击波阵面守恒关系计算获得了JB-9014炸药冲击Hugoniot数据,采用正交回归直线拟合得到了炸药样品在3.1～8.2 GPa压力范围内的冲击Hugoniot关系:D_s=2.417+2.140u_s (D_s和u_s的单位均为km/s)。结果表明:该方法测试精度较高,响应时间快(小于5 ns),同时该方法可以对炸药的反应情况进行检测,便于判断实验是否测得真实的未反应炸药冲击Hugoniot数据。     

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration

Low back pain, triggered by intervertebral disc degeneration (IVDD), is one of the most common causes of disability and financial expenditure worldwide. However, except for surgical interventions, effective medical treatment to prevent the progression of IVDD is lacking. This study aimed to investigate the effects of circKIF18A, a novel circRNA, on IVDD progression and to explore its underlying mechanism in IVDD. In this study, we found that oxidative stress was positively correlated with nucleus pulposus cell (NPC) senescence in IVDD and that circKIF18A was downregulated in IVDD and attenuated senescent phenotypes such as cell cycle arrest and extracellular matrix degradation in NPCs. Mechanistically, circKIF18A competitively suppressed ubiquitin-mediated proteasomal degradation of MCM7, and the protective effects of circKIF18A on NPCs were partially mediated by MCM7 under oxidative stress. Intradiscal injection of adenoviral circKIF18A ameliorated IVDD in a rat model. This study revealed that circKIF18A regulates NPC degeneration by stabilizing MCM7 and identified a novel signaling pathway, the circKIF18A-MCM7 axis, for anti-senescence molecular therapy in IVDD.Subject terms: Diseases, Ageing