Fabrication of hyaluronic acid-based nanoparticles and studies on their radical scavenging activity

The purpose of this paper is to study the stability, radical scavenging activities, and bio-safety of cysteine-conjugated hyaluronic acid nanoparticles (Cys-conj-HA NPs). Additionally, the feasibility of utilizing these NPs as drug delivery systems is discussed. The structures of synthesized Cys-conj-HA polymers were analyzed using ¹H nuclear magnetic spectrum (¹H NMR) and Fourier transform infrared spectroscopy (FTIR) spectra. The stability, radical scavenging activity, and bio-safety of fabricated Cys-conj-HA NPs were investigated. Transmission electron microscopy (TEM) photograph illustrated that Cys-conj-HA NPs possessed spherical shapes with an average diameter of approximately 230 nm. Furthermore, these NPs exhibited high stability at temperatures of 4, 25, and 37°C. Notably, Cys-conj-HA NPs demonstrated significant free radical scavenging capabilities. The high cell viability observed indicated the absence of cytotoxicity from Cys-conj-HA NPs. Additionally, bio-safety studies revealed that these NPs did not induce acute toxicity in the blood and viscera of cargo-free NPs treated mice. Elisa assays indicated that there was no significant difference in the concentrations of interferon-γ (INF-γ) and tumor necrosis factor-α (TNF-α) between Cys-conj-HA NPs and normal saline (NS) treated mice (ns, p > 0.05), suggesting the absence of an inflammatory reaction caused by these NPs. Consequently, it can be concluded that Cys-conj-HA NPs are sufficiently safe to be employed as a vehicle for delivering oxidizing drugs.     

Modulation Mechanism of Transition Elements Fe and Mn on the Interface Bonding Performance of Bronze/Diamond Composites

The modulation mechanism of iron (Fe) and manganese (Mn) in transition-metal elements on the interface bonding and mechanical properties of bronze (Cu₃Sn)-based/diamond composites is investigated through first-principles calculations. Transition-elements-doping scenarios are investigated employing six-layer slab models. It is revealed that the doping of Fe or Mn can make the Cu₃Sn/diamond interface more stable, which effectively improves the wettability of the Cu₃Sn/diamond interface based on the calculation results and analysis of interface energy, differential charge density model, and density of states. However, co-doping with both Fe and Mn weakens the wettability of the Cu₃Sn/diamond interface. Finally, wettability tests and microstructure characterizations demonstrate that the doping of Fe and Mn represents an effective approach to controlling the interface bonding performance of bronze/diamond composites.     

DYNAMICAL EXPLANATION ON TOROFLUX'S PHENOMENA

本文分析了流动环特殊现象的力学原理。流动环是由细长钢带缠绕形成的环状螺旋玩具,具有瞬间几何形态突变和绕圆柱物体运动时迅速旋转两种独特现象。文中利用封闭曲杆的拓扑学规律确定其曲率和扭率,用于计算和比较流动环两种平衡状态的弹性变形势能。证实流动环的形态突变源于最小弹性势能原理。以组成流动环的单个圆环为分析对象,且考虑邻近圆环的牵拉效应。分析了流动环下落时相对圆柱体的滚动过程,以解释旋转现象的产生原因。导出了流动环下落旋转的角加速度公式。理论计算结果与实验数据较好吻合。     

Multiscale permutation mutual information quantify the information interaction for traffic time series

Pendulums and similar systems, such as links of chains, bodies hanging on ropes, kinematic chains forming working parts of manipulators, and robotic devices, are frequently used in industrial applications. They often cooperate in tubes or working spaces limited by walls or other rigid obstacles. This was the inspiration to carry out this study on the influence of impacts on the behaviour of a chain-like system represented by a double pendulum moving between two vertical walls. The simulations were performed for a specified extent of excitation frequencies. The results indicate a number of bifurcations that change the character of the induced motion to regular, quasi-periodic, and chaotic in the individual frequency subintervals.

     

Complexity analysis of multiscale multivariate time series based on entropy plane via vector visibility graph

Nonlinear Dynamics - Vector visibility graph (VVG) is an algorithm that transforms multivariate time series into directed complex networks. However, at present, the researches of VVG mainly focus...     

正丁醇、乙酸乙酯、正己烷的二元及三元体系的超额焓测量和关联

用等温稀释量热计测定了正己烷+正丁醇、正己烷+乙酸乙酯二元体系在303.15K、308.15K及正丁醇+乙酸乙酯+正己烷三元体系在303.15K的超额焓,用Kretschrner-Wiebe理论组合UNIQUAC方程所得数学模型对二元体系在303.15K的超颠焓进行了关联,并预测了所测三元体系在303.15K的超额焓,预测结果与实验值比较,平均偏差为6％。     

环面薄膜的膨胀失稳

本文从有限弹性理论出发对超弹性薄膜轴对称大变形问题进行了一般的数学描述.基于本文所导出的基本方程,应用打靶法数值地分析了Mooney-Rivlin型类橡胶环面薄膜的大变形膨胀失稳问题.给出了上、下极限载荷和位移载荷曲线.     

掺杂λ-MnO2的制备及其在KOH水溶液中的电化学性质

电化学性能;碱性溶液;掺杂λ-MnO2的制备及其在KOH水溶液中的电化学性质     

砷(Ⅲ)-碘酸钾-溴化钾-甲基红动力学分光光度法测定水样中微量砷(Ⅲ)的研究

本文研究了在盐酸溶液中砷（Ⅲ）—碘酸钾—溴化钾—甲基红褪色反应及影响褪色速度的因素,建立了动力学分光光度法测定水样中微量砷（Ⅲ）的新方法。方法灵敏度为2.4×10-9克砷（Ⅲ）/毫升,测定范围0～11微克砷（Ⅲ）/25毫升,并具有操作简便、快速,分析结果稳定,分析费用低廉等