An efficient synthesis of substituted bis(indolyl)methanes using sodium bromate and sodium hydrogen sulfite in water

Treatment of indole with substituted aldehyde in the presence of equimolar amount of sodium bromate and sodium hydrogen sulfite mixture in water yielded corresponding substituted bis(indolyl)methanes in good yields. This provides a facile and environmentally friendly method towards the synthesis of an important class of organic compounds.     

Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases in many mammalian bodies and promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities and numerous bioactive properties due to which it has been considered as a traditional medicine for decades. Apigenin shows synergistic effects in combined treatment with sorafenib in the HepG2 human cell line (HCC) in less time and statistically reduces the viability of tumor cells, migration, gene expression and apoptosis. The combination of anti-cancerous drugs with apigenin has shown health promoting potential against various cancers. It can prevent cell mobility, maintain the cell cycle and stimulate the immune system. Apigenin also suppresses mTOR activity and raises the UVB-induced phagocytosis and reduces the cancerous cell proliferation and growth. It also has a high safety threshold, and active (anti-cancer) doses can be gained by consuming a vegetable and apigenin rich diet. Apigenin also boosted autophagosome formation, decreased cell proliferation and activated autophagy by preventing the activity of the PI3K pathway, specifically in HepG2 cells. This paper provides an updated overview of apigenin’s beneficial anti-inflammatory, antibacterial, antiviral, and anticancer effects, making it a step in the right direction for therapeutics. This study also critically analyzed the effect of apigenin on cancer cell signaling pathways including the PI3K/AKT/MTOR, JAK/STAT, NF-κB and ERK/MAPK pathways.     

An improved Darcian analysis for chemically reacted Maxwell liquid toward convectively heated moving surface with magnetohydrodynamics

Journal of Thermal Analysis and Calorimetry - Heat transportation analysis subjected to porous medium consideration has increased because of industrial and engineering utilization. Typical examples...     

Effective Assignment of α2,3/α2,6‐Sialic Acid Isomers by LC‐MS/MS‐Based Glycoproteomics

Distinct structural changes of the α2,3/α2,6‐sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high‐throughput characterization of sialic acid isomers. To enable such assignments, a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios was developed. This method was successfully applied in large‐scale glycoproteomics, thus allowing the site‐specific structural characterization of sialic acid isomers.     

Magneto-hydrodynamical numerical simulation of heat transfer in MHD stagnation point flow of Cross fluid model towards a stretched surface

Here formulation and computations are presented to introduce the novel concept of activation energy in chemically reacting stagnation point flow towards a stretching sheet. Constitutive expression for Cross liquid is taken into account. Magnetic field is utilised in the transverse direction. Application of suitable variables generates the non-linear differential systems. Numerical solution by Runge–Kutta–Fehlberg approach is presented. Characteristics for the significant variables like Weissenberg number, Hartmann number, Schmidt number, activation energy chemical reaction parameter, velocity ratio parameter and Prandtl number on the physical quantities are addressed through graphs and tables. Our computations reveal that species concentration rises via larger activation energy parameter whereas it decays when Schmidt number is incremented. The Weissenberg number has opposite characteristics for local Nusselt and Sherwood numbers when compared with surface drag force.     

A proposed unsteady bioconvection model for transient thin film flow of rate-type nanoparticles configured by rotating disk

Journal of Thermal Analysis and Calorimetry - The revolution in nanotechnology has made new developments toward enhancement of energy resources which play a substantial role in the growth of...     

Computational engineering to enhance the photovoltaic by end-capped and bridging core alterations: Empowering the future with solar energy through synergistic effect in D-A materials

Organic photovoltaic solar cells are being designed to offer a low energy photovoltaic (PV) solution. Optimizing the molecular backbone is one the most important technique for improving the photovoltaic characteristic of A-D-A type small active layer molecules. Herein, we have designed and theoretical characterized six new molecules by end-capped and bridging core modifications of recently synthesized molecule BFHIC-4F. Enhancement in photovoltaic, optoelectronic and physio-chemical properties of newly designed molecules are seen by doing such modifications. Different advanced quantum chemical techniques have been employed to evaluate the performance of newly planned molecules. Large open circuit voltage and narrow band gap suggested that the designed molecules are efficient aspirants for solar cell applications. Moreover, maximum absorption capability in near-infra-red (NIR) region is observed for these newly designed molecules. To sum up, outcomes of all analyses advocated that the designed molecules are efficient candidates for solar cell applications.     

Evaluation of quantum dots applied as switchable layer in a light-controlled electrochemical sensor

Gold electrodes with switchable conductance are created by coating the gold surface with different colloidal quantum dots. For the quantum dot immobilization, a dithiol compound was used. By polarizing the electrode and applying a light pointer, local photocurrents were generated. The performance of this setup was characterized for a variety of different nanoparticle materials regarding drift and signal-to-noise ratio. We varied the following parameters: quantum dot materials and immobilization protocol. The results indicate that the performance of the sensor strongly depends on how the quantum dots are bound to the gold electrode. The best results were obtained by inclusion of an additional polyelectrolyte film, which had been fabricated using layer-by-layer assembly.