Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp

Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD₅₀ values between 92 and 106 μg/mL.     

PAST AND FUTURE MANAGEMENT OF A COLLAPSED FISHERY: THE BAY OF BISCAY ANCHOVY

Abstract We analyze the efficiency of the international management of the Bay of Biscay anchovy. While a sharing agreement between France and Spain has been in place since 1992, the fish stock collapsed in 2005 and the fishery closed from 2005 to spring 2010. We consider differences in production technologies between both countries and calibrate our model using data from 1987 to 2009. Our results suggest two sources of rent dissipation under the existing sharing agreement: inefficient quota allocation and production inefficiencies due to inflexible national regulations. We discuss several alternatives to improve management.     

Two ring-A-aromatized bile acids from the marine sponge Sollasella moretonensis

Two ring-A-aromatized bile acids, 1 and 2, were isolated from the sponge Sollasella moretonensis, collected from the seabed of northern Queensland. Structures were assigned on the basis of extensive 1D and 2D NMR studies, as well as analysis by HRESIMS. Compound 2 has previously been produced synthetically, though this marks its first isolation from a natural source.     

Analytical springback model for lightweight hexagonal close-packed sheet metal

Experiments have shown that magnesium alloy sheet a common hexagonal close-packed metal, exhibits mechanical behavior unlike that of sheets made of cubic metals (X.Y. Lou et al., 2007, Int. J. Plasticity, 24, 44). The unique stress–strain response includes a strong asymmetry in the initial yield and subsequent plastic hardening. In other words, the stress–strain curves in tension and compression are significantly different. A proper representation of the constitutive relationships is crucial for the accurate evaluation of springback, which occurs due to the residual moment distribution through the sheet thickness after bending. In this paper, we propose an analytical model for asymmetric elasto-plastic bending under tension followed by elastic unloading in order to evaluate the bending moment, which is equivalent to the springback amount. To simplify the calculations, the experimentally measured stress–strain curve of the magnesium alloy sheet was approximated with discrete linear hardening in each deformation region, and the material properties were characterized according to several simplifying assumptions. The bending moment was calculated analytically using the approximate asymmetric stress–strain relationship up to the prescribed curvature corresponding to the radius of the tool in sheet metal forming operations. A numerical example showed an unusual springback increase, even with an increase in the applied force; this is an unexpected result for conventional symmetric materials. We also compared the calculated springback amounts with the results of physical measurements. This showed that the proposed model predicts the main trends of the springback in magnesium alloy sheets reasonably well considering the simplicity of the analytical approach.     

Juxtaposition of Chemical and Mutation-Induced Developmental Defects in Zebrafish Reveal a Copper-Chelating Activity for Kalihinol F

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