A mild and novel synthesis of functionalized fused imidazole analogues under environmentally benign reaction media

A mild and novel approach is described for the synthesis of functionalized fused imidazole analogues in solvent-free and catalyst-free condition in ionic liquid. The short reaction time, good isolated yields, generality and environmentally benign reaction media are the significant features of this protocol.     

Vibrational dynamics and heat capacity in poly(L‐lactic acid)

Poly(L ‐lactic acid) (PLLA) (? CH(CH₃) ? COO? )_n is a biodegradable polymer, which exhibits many applications in the biomedical field and where thermoplastics are employed. A comprehensive study of the normal modes and their dispersion in PLLA using Wilson′s GF matrix method as modified by Higgs is being reported. Assignments of calculated normal modes have been made and characteristic features of dispersion curves are discussed. Heat capacity has been calculated via density‐of‐states using Debye relation in the temperature range 10–250 K, which is in fairly good agreement with the experimental data. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 175–182, 2010     

Biosynthesized Zinc Oxide Nanoparticles as Efficient Photocatalytic and Antimicrobial Agent

This work reports an innovative, effortless and inexpensive method for the preparation of ZnO nanoparticles by green approach using leaf extract of Piper betleas a reducing-stabilizing negotiator. The prepared ZnO NPs were characterized through XRD, FTIR, UV–Visible spectroscopy, and EDX etc. The band gap energy of the sample was estimated as 3.41 eV which is larger than the bulk ZnO (E_g?=?3.37 eV). The observed blue shift is attributed to the quantum confinement of excitons. FTIR analysis showed the presence of alkaloids, flavonoids, polyphenols, and terpenoid. TEM analysis showed that each nanoparticle comprised of 1 to 2 nano-crystallites. Photocatalytic activity results revealed that ZnO-NPs prepared through green synthesis route were found to be efficient in the degradation of toxic reactive red dye with degradation efficiency of 96.4% having high photodegradation rate-constant of 1.6?×?10^–2 min^?1. As an antimicrobial agent, the ZnO NPs are effective against both gram-positive (Bacillus subtilis) and negative bacteria (Escherichia coli), with the zones of clearance as 16.4 and 14.3 mm, respectively. Therefore, present research signifies an effective approach to utilize as-prepared ZnO NPs as efficient photocatalysts as well as antimicrobial agent.

     

Group of units of group algebras

By a right (left resp.) S_2n-polynomial we mean a multilinear polynomial f(X₁,…, X_t) over the ring of integers with noncommuting in-determinates X_isuch that for any prime ring R if f( X₁,…, X _t) is a PI of some nonzero right (left resp.) ideal of R, then R satisfies S_2nthe standard identity of degree 2n. In this paper we prove the theorem:Let R be a prime ring, d a nonzero derivation of R, L a noncommutative Lie ideal of R and f(X₁,…, X_t) a right or left S_2n-polynomial. Suppose that f(d( u₁)ⁿ¹,…,d(u_t)^nt)=0 for all u_iu,_i[d] L, where n₁,…,n_tare fixed positive integers. Then R satisfies S_2n+2. Also, the one-sided version of the theorem is given.     

Highly Sensitive and Selective Voltammetric Sensor Fullerene Modified Glassy Carbon Electrode for Determination of Cefitizoxime in Solubilized System

The usefulness of fullerene modified glassy carbon electrode in mediating the reduction of cefitizoxime in solubilized system has been demonstrated. Due to the unique structure and extraordinary properties, fullerene shows higher catalytic efficiency towards cefitizoxime reduction. The kinetic parameters, electron transfer coefficient (α) and rate constant (K₀) across the modified electrode are 0.37 and 0.1081/s respectively. The proposed square‐wave voltammetric method is linear over the concentration range 1.2–10.3 µg/mL. The limit of detection (LOD) is found 0.27 ng/mL. High sensitivity and selectivity together with low detection limit of the electrode response make it suitable for the determination of cefitizoxime.     

Substrate assisted electrochemical deposition of patterned cobalt thin films

The patterned Co layers deposited on the scratched Cu surfaces were investigated with the use of the scanning electron microscopy. Patterned cobalt thin films were electrochemically deposited from the cobalt sulfate bath at room temperature. Pattering of cobalt was carried out by simple means of substrate scratching. Gentle scratching induces a direct pattering of cobalt from vertical to horizontal. The prepared pattered films were characterized for their structural, surface morphological and compositional properties by means of X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy. X-ray diffraction studies reveal that the films are of cobalt. From the SEM images fabrication of patterns of cobalt is apparent. This work demonstrates a novel approach for obtaining patterned cobalt for many technological applications.     

Efficient Elemental Iodine Catalyzed One-Pot Synthesis of 2,4,5-Triarylimidazoles

Summary. Elemental iodine is used as an efficient catalyst for the synthesis of 2,4,5-triarylimidazoles in excellent yields via condensation of benzoin, ammonium acetate, and aromatic aldehydes. This is a simple, one-pot, high yielding technique using cheap, non-toxic iodine in catalytic amounts.     

A Characterization of Nash Equilibrium for the Games with Random Payoffs

We consider a two-player random bimatrix game where each player is interested in the payoffs which can be obtained with certain confidence. The payoff function of each player is defined using a chance constraint. We consider the case where the entries of the random payoff matrix of each player jointly follow a multivariate elliptically symmetric distribution. We show an equivalence between the Nash equilibrium problem and the global maximization of a certain mathematical program. The case where the entries of the payoff matrices are independent normal/Cauchy random variables is also considered. The case of independent normally distributed random payoffs can be viewed as a special case of a multivariate elliptically symmetric distributed random payoffs. As for Cauchy distribution, we show that the Nash equilibrium problem is equivalent to the global maximization of a certain quadratic program. Our theoretical results are illustrated by considering randomly generated instances of the game.     

Efficient Elemental Iodine Catalyzed One-Pot Synthesis of 2,4,5-Triarylimidazoles

Elemental iodine is used as an efficient catalyst for the synthesis of 2,4,5-triarylimidazoles in excellent yields via condensation of benzoin, ammonium acetate, and aromatic aldehydes. This is a simple, one-pot, high yielding technique using cheap, non-toxic iodine in catalytic amounts.     

Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. NQO1 is a multifunctional antioxidant enzyme whose expression and deletion are linked to reduced and increased oxidative stress susceptibilities. NQO1 acts as both a tumor suppressor and tumor promoter; thus, the inhibition of NQO1 results in less tumor burden. In addition, the high expression of NQO1 is associated with a shorter survival time of cancer patients. Inhibiting NQO1 also enables certain anticancer agents to evade the detoxification process. In this study, a series of phytobioactives were screened based on their chemical classes such as coumarins, flavonoids, and triterpenoids for their action on NQO1. The in silico evaluations were conducted using PyRx virtual screening tools, where the flavone compound, Orientin showed a better binding affinity score of −8.18 when compared with standard inhibitor Dicumarol with favorable ADME properties. An MD simulation study found that the Orientin binding to NQO1 away from the substrate-binding site induces a potential conformational change in the substrate-binding site, thereby inhibiting substrate accessibility towards the FAD-binding domain. Furthermore, with this computational approach we are offering a scope for validation of the new therapeutic components for their in vitro and in vivo efficacy against NQO1.