Influence of low intensity noise on assemblies of diffusively coupled chaotic cells

The effect of time-correlated and white Gaussian noises of low intensity on one-dimensional arrays consisting of diffusively coupled chaotic cells is analyzed. An improvement or worsening of the synchronization between cells of the array driven by low-intensity colored noise is observed for a resonant interval of time correlation values. A comparison between colored and white noise and additive and multiplicative contribution has been carried out investigating the nonlinear cooperative effects of noise strength, correlation time, and coupling strength to control spatiotemporal chaos in coupled arrays of chaotic cells. The possibility to distinguish highly correlated areas of a diffusively coupled network of cells by using low-intensity time correlated noise is discussed. (c) 2001 American Institute of Physics.     

Temperature-Controlled Stereodivergent Synthesis of 2,2′-Biflavanones Promoted by Samarium Diiodide

In this work, the first example of a radical stereodivergent reaction directed towards the stereoselective synthesis of both (R*,R*)- and (R*,S*)-2,2′-biflavanones promoted by samarium diiodide is reported. Control experiments showed that the selectivity of this reaction was exclusively controlled by the temperature. It was possible to generate a variety of 2,2′-biflavanones bearing different substitution patterns at the aromatic ring in good-to-quantitative yields, being both stereoisomers of the desired compounds obtained with total or high control of selectivity. A mechanism that explains both the generation of the corresponding 2,2′-biflavanones and the selectivity is also discussed. The structure and stereochemistry determination of each isomer was unequivocally elucidated by single-crystal X-ray diffraction experiments.     

MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been observed thorough Mcl-1 overexpression. As a strategy to overcome Mcl-1-mediated resistance, herein we present a controlled drug co-delivery system based on mesoporous silica nanoparticles (MSNs) targeted to TNBC cells. The nanocarrier is loaded with navitoclax and the Mcl-1 inhibitor S63845 and capped with a MUC1-targeting aptamer ( apMUC1-MSNs(Nav/S63845) ). The apMUC1-capped nanoparticles effectively target TNBC cell lines and successfully induce apoptosis, overcoming navitoclax resistance. Moreover, navitoclax encapsulation protects platelets against apoptosis. These results point apMUC1-gated MSNs as suitable BH3 mimetics nanocarriers in the targeted treatment of MUC1-expressing TNBC.     

Two-Photon Absorption Enhancement by the Inclusion of a Tropone Ring in Distorted Nanographene Ribbons

A new family of distorted ribbon-shaped nanographenes was designed, synthesized, and their optical and electrochemical properties were evaluated, pointing out an unprecedented correlation between their structural characteristics and the two-photon absorption (TPA) responses and electrochemical band gaps. Three nanographene ribbons have been prepared: a seven-membered-ring-containing nanographene presenting a tropone moiety at the edge, its full-carbon analogue, and a purely hexagonal one. We have found that the TPA cross-sections and the electrochemical band gaps of the seven-membered-ring-containing compounds are higher and lower, respectively, than those of the fully hexagonal polycyclic aromatic hydrocarbon (PAH). Interestingly, the inclusion of additional curvature has a positive effect in terms of non-linear optical properties of those ribbons.     

Spectra of fast π + mesons from the π − A → π + X reaction on oxygen and lithium nuclei at 0.59 GeV

The spectra of fast π ⁺ mesons from the π ^? A → π ⁺ X reaction on A=⁶Li, ⁷Li, and ¹⁶O nuclei at a primary momentum of p ₀=0.72 GeV/c (T ₀=0.59 GeV) are measured at emission-angle values in the range ?=0°–14°. The results obtained in this way are compared with experimental data taken in other studies at lower energies and with the results of model calculations. The energy dependence of the cross sections and of shadowing effects is analyzed for the reactions in question that occur on lithium isotopes.     

Another Proof for the Presentation of the Quantum Cohomology of the Moduli of Bundles over a Riemann Surface

The presentation of the quantum cohomology of the moduli spaceof stable vector bundles of rank two and odd degree with fixeddeterminant over a Riemann surface of genus g > 2 is obtained.The argument avoids the use of gauge theory, providing an alternativeproof to that given by the author in Duke Math. J. 98 (1999)525–540. 2000 Mathematics Subject Classification 14N35(primary); 14H60, 53D45 (secondary).     

Discrete linear bilevel programming problem

In this paper, we analyze some properties of the discrete linear bilevel program for different discretizations of the set of variables. We study the geometry of the feasible set and discuss the existence of an optimal solution. We also establish equivalences between different classes of discrete linear bilevel programs and particular linear multilevel programming problems. These equivalences are based on concave penalty functions and can be used to design penalty function methods for the solution of discrete linear bilevel programs.Support of this work has been provided by the INIC (Portugal) under Contract 89/EXA/5, by INVOTAN, FLAD, and CCLA (Portugal), and by FCAR (Québec), NSERC, and DND-ARP (Canada).     

Orlicz function spaces without complemented copies ofl p

This paper proves the existence of Orlicz function spaces Lφ (0, 1) containing no complemented subspaces isomorphic tol ^p for anyp ≠ 2. Some properties of minimal Orlicz function spaces Lφ (0, 1) are also given. Supported in part by CAICYT grant 0338-84.     

Heuristic solution approaches for the maximum minsum dispersion problem

The Maximum Minsum Dispersion Problem (Max-Minsum DP) is a strongly NP-Hard problem that belongs to the family of equitable dispersion problems. When dealing with dispersion, the operations research literature has focused on optimizing efficiency-based objectives while neglecting, for the most part, measures of equity. The most common efficiency-based functions are the sum of the inter-element distances or the minimum inter-element distance. Equitable dispersion problems, on the other hand, attempt to address the balance between efficiency and equity when selecting a subset of elements from a larger set. The objective of the Max-Minsum DP is to maximize the minimum aggregate dispersion among the chosen elements. We develop tabu search and GRASP solution procedures for this problem and compare them against the best in the literature. We also apply LocalSolver, a commercially available black-box optimizer, to compare our results. Our computational experiments show that we are able to establish new benchmarks in the solution of the Max-Minsum DP.