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991.
Linking an α‐Tocopherol Derivative to Cobalt(0) Nanomagnets: Magnetically Responsive Antioxidants with Superior Radical Trapping Activity and Reduced Cytotoxicity
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Dr. Caterina Viglianisi Veronica Di Pilla Prof. Stefano Menichetti Prof. Vincent M. Rotello Dr. Gabriele Candiani Chiara Malloggi Dr. Riccardo Amorati 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(23):6857-6860
Covalent attachment of a phenolic antioxidant analogue of α‐tocopherol to graphite‐coated magnetic cobalt nanoparticles (CoNPs) provided a novel magnetically responsive antioxidant capable of preventing the autoxidation of organic materials and showing a reduced toxicity toward human cells. 相似文献
992.
Ditte L. Thomsen Charles M. Nichols Jennifer N. Reece Steen Hammerum Veronica M. Bierbaum 《Journal of the American Society for Mass Spectrometry》2014,25(2):159-168
The enhanced reactivity of α-nucleophiles, which contain an electron lone pair adjacent to the reactive site, has been demonstrated in solution and in the gas phase and, recently, for the gas-phase SN2 reactions of the microsolvated HOO–(H2O) ion with methyl chloride. In the present work, we continue to explore the significance of microsolvation on the α-effect as we compare the gas-phase reactivity of the microsolvated α-nucleophile HOO–(H2O) with that of microsolvated normal alkoxy nucleophiles, RO–(H2O), in reactions with methyl formate, where three competing reactions are possible. The results reveal enhanced reactivity of HOO–(H2O) towards methyl formate, and clearly demonstrate the presence of an overall α-effect for the reactions of the microsolvated α-nucleophile. The association of the nucleophiles with a single water molecule significantly lowers the degree of proton abstraction and increases the SN2 and BAC2 reactivity compared with the unsolvated analogs. HOO–(H2O) reacts with methyl formate exclusively via the BAC2 channel. While microsolvation lowers the overall reaction efficiency, it enhances the BAC2 reaction efficiency for all anions compared with the unsolvated analogs. This may be explained by participation of the solvent water molecule in the BAC2 reaction in a way that continuously stabilizes the negative charge throughout the reaction.
Figure 相似文献
993.
The authors extend their recent method for the computation of vibrationally resolved optical spectra of large molecules, including both the Duschinsky rotation and the effect of finite temperature in the framework of the Franck-Condon (FC) approximation, to deal with the more general case of the Herzberg-Teller (HT) model, where also the linear dependence of the transition dipole moment on the nuclear coordinates is taken into account. This generalization allows us to investigate weak and vibronically allowed transitions by far extending the range of application of the method. The calculation of the spectra of sizable molecules is computationally demanding because of the huge number of final vibrational states that must be taken into account, and the inclusion of HT terms further increases the computational burden. The method presented here automatically selects the relevant vibronic contributions to the spectrum, independent of their frequency, and it is able to provide fully converged spectra with a modest computational requirement. The effectiveness of the method is illustrated by computing the HT absorption and fluorescence Q(x) spectra of free-base porphyrin both at T=0 K and at room temperature, performing for the first time an exact treatment of vibrations in harmonic approximation. Q(x) spectra are compared to experiments and FC/HT interferences are analyzed in detail. 相似文献
994.
995.
Dr. Miguel A. Soto Dr. Veronica Carta Ingrid Suzana Dr. Brian O. Patrick Prof. Francesco Lelj Prof. Mark J. MacLachlan 《Angewandte Chemie (International ed. in English)》2023,62(4):e202216029
Macrocycle engineering is a key topic in supramolecular chemistry. When synthesizing a ring, one can obtain either complex mixtures of macrocycles of different sizes or a single ring if a template is utilized. Here, we unite these approaches along with post-synthetic modifications to transform a single tether into multiple rings—up to five per tether. The macrocycles contain two bridged phenylpyridine ligands that are connected through a Pt atom, which defines the rings’ shape, size, and host activity. All rings undergo redox reactions (between PtII and PtIV) that allow for large conformational changes. Their reactivity, together with their host performance, is a convenient way to control the capture and release of guests, to mediate ring transformations, and to control pseudorotaxane-to-pseudorotaxane conversions. This novel approach could serve to assemble other libraries of small ring molecules, create cyclic polymers bridged by responsive-at-metal nodes, and produce processable mechanically interlocked molecules. 相似文献
996.
Dunlop J Bowlby M Peri R Tawa G LaRocque J Soloveva V Morin J 《Combinatorial chemistry & high throughput screening》2008,11(7):514-522
Ion channels are attractive targets for drug discovery with recent estimates indicating that voltage and ligand-gated channels account for the third and fourth largest gene families represented in company portfolios after the G protein coupled and nuclear hormone receptor families. A historical limitation on ion channel targeted drug discovery in the form of the extremely low throughput nature of the gold standard assay for assessing functional activity, patch clamp electrophysiology in mammalian cells, has been overcome by the implementation of multi-well plate format cell-based screening strategies for ion channels. These have taken advantage of various approaches to monitor ion flux or membrane potential using radioactive, non-radioactive, spectroscopic and fluorescence measurements and have significantly impacted both high-throughput screening and lead optimization efforts. In addition, major advances have been made in the development of automated electrophysiological platforms to increase capacity for cell-based screening using formats aimed at recapitulating the gold standard assay. This review addresses the options available for cell-based screening of ion channels with examples of their utility and presents case studies on the successful implementation of high-throughput screening campaigns for a ligand-gated ion channel using a fluorescent calcium indicator, and a voltage-gated ion channel using a fluorescent membrane potential sensitive dye. 相似文献
997.
Company A Roques N Güell M Mugnaini V Gómez L Imaz I Datcu A Solà M Luis JM Veciana J Ribas X Costas M 《Dalton transactions (Cambridge, England : 2003)》2008,(13):1679-1682
3D coordination cages have been synthesized via the supramolecular 3 + 2 self-assembly of macrocyclic dicopper molecular clips and tricarboxylate linkers, the nature of which allows the introduction of different functionalities to the 3D cages. 相似文献
998.
De Angelis F Santoro F Nazeruddin MK Barone V 《The journal of physical chemistry. B》2008,112(42):13181-13183
We performed fully first principles quantum mechanical calculations of the ground and excited state geometries and harmonic vibrational frequencies of two prototype cationic Ir(III) complexes showing high emission quantum efficiencies. Thanks to recent theoretical advances, we have been able for the first time to simulate their vibrationally resolved emission spectra. Our results, in good agreement with the experiment, allow us to calculate the CIE coordinates and therefore the emission color of this important class of emitters for OLEDs and LECs. 相似文献
999.
The dynamics of overtone-excited pyruvic acid (PA) is studied using a combination of experimental and theoretical methods. It is experimentally observed that high overtone excitation of the OH-stretching mode of PA in the gas phase leads to a unimolecular decarboxylation reaction. An RRKM analysis of the rate is consistent with previous experiments for the thermal reaction but is inconsistent with the present overtone chemistry; from this it is concluded that the overtone-induced reaction is likely to be a direct reaction. Using a Fourier transform infrared spectrometer and a cavity ring-down spectrometer, the spectrum for the OH-stretch fundamental and overtone transitions is measured. We assign two conformers of PA in the spectrum, the Tc and Tt, corresponding to distinct orientations of the OH-group. The spectral peaks for the Tc-conformer broaden dramatically at the third and fourth overtones while those of the Tt-conformer remain relatively narrow. Using a three-mode quantum mechanical model for the vibrational states, the line positions and intensities are well reproduced by theory. The line widths, and the associated dynamical interpretation, are provided by a direct dynamics calculation, where the potential is computed "on-the-fly" and all degrees of freedom are included. It is found that the line broadening is due to the onset of H-atom chattering between the two O-atoms, an effect that occurs for the Tc-conformer but not the Tt-conformer. This H-atom-transfer process is the first step of the decarboxylation reaction mechanism, which subsequently involves breaking the C-C bond. The theoretical and experimental line widths agree but do not correspond to the full reaction time which is much longer than the initial chattering step. 相似文献
1000.
M Colombo S Mazzucchelli V Collico S Avvakumova L Pandolfi F Corsi F Porta D Prosperi 《Angewandte Chemie (International ed. in English)》2012,51(37):9272-9275
All bound up: A small variant of protein?A was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio-nanoparticle systems suitable for selective cell labeling by membrane-receptor-specific recognition. 相似文献