An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin

Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity for potential cellular targets. However, using an integrated proteomics-based target-response profiling approach as a potent hypothesis-generating procedure, we found an unexpected target selectivity of a ruthenium(arene) pyridinecarbothioamide (plecstatin) for plectin, a scaffold protein and cytolinker, which was validated in a plectin knock-out model in vitro. Plectin targeting shows potential as a strategy to inhibit tumor invasiveness as shown in cultured tumor spheroids while oral administration of plecstatin-1 to mice reduces tumor growth more efficiently in the invasive B16 melanoma than in the CT26 colon tumor model.     

Transient compressible boundary layer on a wedge impulsively set into motion

Summary The development of a compressible boundary layer over a wedge impulsively set into motion is studied in this paper. The initial motion is independent of the leading edge effect and the solutions are those of a Rayleigh-type problem. The motion tends to an ultimate steady state of Falkner-Skan type. The equations governing the transient boundary layer from the initial steady state to the terminal steady-state change their character after certain time due to the leading edge effect and thereafter solution depends on both the end conditions. Numerical solutions are obtained through the second-order accuracy upwind scheme. The effects of the Falkner-Skan parameter and the surface temperature on the transient flow and heat transfer are also studied. It has been found that the flow separation does not occur form–0.0707 when _w = 1.5 (hot wall), andm–0.118 when _0.5 (cold wall).     

A simple synthesis of a targeted drug delivery system with enhanced cytotoxicity

A simple synthesis of a targeted drug delivery system with enhanced cytotoxicity to (epidermal growth factor receptor) EGFR(+) cancer cells.     

Electric-field induced elastic stretching of multiwalled carbon nanotube clusters: a realistic model

The oscillating electric-field induced stretching phenomenon of multiwalled carbon nanotube (MWCNT) clusters in liquid crystal medium demonstrates distinct threshold behaviour under optical microscopic investigation. The optimum field required for the initiation of MWCNT cluster stretching is found to depend on their length in the field-off state. The phenomenon has been explained in light of a classical theoretical model assuming MWCNT agglomerates as a single electric dipole. The spring constant and induced charge obtained by fitting the formulated theoretical model show good agreement with previous reports, hence establish the proposed dipolar reorientation mechanism of MWCNT clusters induced by the electric field.     

Analysis of Slot Orientation in Shear-Compression Specimen (SCS)

This paper presents an analytical treatment as well as experimental measurement of the plastic deformation field in shear-compression specimen (SCS) by using digital image processing (DIC) technique. The results provide a set of useful expressions that relates externally applied displacement and load quantities to the equivalent stress and equivalent plastic strain within the gage section. Based on the analysis, we propose modifying the slot angle of SCS geometry from its original value of 45º to 35.26º in order to enhance the uniformity of stress and strain fields in gage section. It is shown by analysis that this enhancement is essentially because the compatibility and boundary conditions that yield a homogeneous deformation field is naturally satisfied for the particular slot orientation of ???=?35.26°. This conclusion is also supported by experimental evidence that comparatively shows the edge effects for varying slot angles.     

Texture evolution via combined slip and deformation twinning in rolled silver-copper cast eutectic nanocomposite

In this work, a silver-copper (Ag-Cu) nanocomposite with 200 nm bilayer thickness and eutectic composition was rolled at room temperature and 200 °C to nominal reductions of 75% and higher. Initially the material had a random texture and {1 1 1} bi-metal interface plane. X-ray diffraction measurements show that the Ag and Cu phases developed the same brass-type (or ‘alloy-type’) rolling texture regardless of rolling reduction and temperature. Transmission electron microscopy analyses of the nanostructures before and after rolling suggest that adjoining Ag and Cu layers maintained a cube-on-cube relationship but the interface plane changed after rolling. Polycrystal plasticity simulations accounting for plastic slip and deformation twinning in each phase were carried out to explore many possible causes for the brass-type texture development: twinning via a volume effect or barrier effect, Shockley partial slip, and confined layer slip. The results suggest that the observed texture evolution may be due to profuse twinning within both phases. Maintaining the cube-on-cube relationship would then imply that neighboring Ag and Cu crystals twinned by the same variant and on a twin plane non-parallel to the original interface plane. Explanations for this unusual possibility for Cu are provided at the end based on the properties of the Ag-Cu interface.     

Inverse Boundary Value Problem of Determining Up to a Second Order Tensor Appear in the Lower Order Perturbation of a Polyharmonic Operator

Journal of Fourier Analysis and Applications - We consider the following perturbed polyharmonic operator $$\mathcal {L}(x,D)$$ of order 2m defined in a bounded domain $$\Omega \subset \mathbb...     

A Kenmotsu Metric as a *-conformal Yamabe Soliton with Torse Forming Potential Vector Field

Acta Mathematica Sinica, English Series - The purpose of the present paper is to deliberate *-conformal Yamabe soliton, whose potential vector field is torse-forming on Kenmotsu manifold. Here, we...     

Zur Analyse von Eisen und-Stahl

Ohne Zusammenfassung     

Self-assembled lamellar structures with functionalized single wall carbon nanotubes

Highly ordered self-assembled multi-layer structures with denatured collagen wrapped single wall carbon nanotubes and surfactant systems were obtained through bioinspired methodology.