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971.
Lintao Zeng Tianhong Chen Beitong Zhu Seyoung Koo Yonghe Tang Weiying Lin Tony D. James Jong Seung Kim 《Chemical science》2022,13(16):4523
Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. Trans-cyclohexanyldiamine as the reactive site provides optimal geometry and high reactivity, allowing trans-BODIPY-DCH to detect CWAs with a quick response and high sensitivity, while cis-BODIPY-DCH has much weaker reactivity to CWAs due to intramolecular H-bonding. Upon reaction with phosgene, trans-BODIPY-DCH was rapidly converted to imidazolone BODIPY (<3 s), triggering green fluorescence with good sensitivity (LOD = 0.52 nM). trans-BODIPY-DCH coupled with nerve agent mimics, affording a blue fluorescent 8-amino-BODIPY tautomer. Furthermore, a portable test kit using trans-BODIPY-DCH displayed an instant response and low detection limits for multiple CWAs. This platform enables rapid and highly sensitive visual screening of various CWAs.Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, necessitating tools that can simultaneously screen multiple CWAs in seconds. 相似文献
972.
Fang-Zhou Xu Ling Zhu Hai-Hao Han Jian-Wei Zou Yi Zang Jia Li Tony D. James Xiao-Peng He Cheng-Yun Wang 《Chemical science》2022,13(32):9373
Luminogens characteristic of aggregation-induced emission (AIEgens) have been extensively exploited for the development of imaging-guided photodynamic therapeutic (PDT) agents. However, intramolecular rotation of donor–acceptor (D–A) type AIEgens favors non-radiative decay of photonic energy which results in unsatisfactory fluorescence quantum and singlet oxygen yields. To address this issue, we developed several molecularly engineered AIEgens with partially “locked” molecular structures enhancing both fluorescence emission and the production of triplet excitons. A triphenylphosphine group was introduced to form a D–A conjugate, improving water solubility and the capacity for mitochondrial localization of the resulting probes. Experimental and theoretical analyses suggest that the much higher quantum and singlet oxygen yield of a structurally “significantly-locked” probe (LOCK-2) than its “partially locked” (LOCK-1) and “unlocked” equivalent (LOCK-0) is a result of suppressed AIE and twisted intramolecular charge transfer. LOCK-2 was also used for the mitochondrial-targeting, fluorescence image-guided PDT of liver cancer cells.Luminogens characteristic of aggregation-induced emission (AIEgens) have been engineered for the development of imaging-guided photodynamic therapeutic (PDT) agents. 相似文献
973.
Christian Ley Antoine Siedel Tony Bertaux Céline Croutxé-Barghorn Xavier Allonas 《Angewandte Chemie (International ed. in English)》2023,62(11):e202214784
Photobase generators are species that allow the photocatalysis of various reactions, such as thiol-Michael, thiol-isocyanate, and ring-opening polymerization reactions. However, existing compounds have complex syntheses and low quantum yields. To overcome these problems, photobase generators based on the photodecarboxylation reaction were developed. We synthesized and studied the photochemistry and photophysics of two xanthone photobase, their carboxylic acid precursors, and their photoproducts to understand the photobase generation mechanism. We determined accurate quantum yields of triplet states and photobase generation. The effect of the intermediate radical preceding the base release was demonstrated. We characterized the photophysics of the photobase by femtosecond spectroscopy and showed that the photodecarboxylation process occurred from the second excited triplet state with a rate constant of 2.2×109 s−1. 相似文献
974.
Tony Biremond Dr. Margaux Riomet Prof. Dr. Philippe Jubault Prof. Dr. Thomas Poisson 《Chemical record (New York, N.Y.)》2023,23(11):e202300172
Due to their high versatility borylated and silylated compounds are inevitable synthons for organic chemists. To escape the classical hydroboration/hydrosilylation paradigm, chemists turned their attention to more modern and green methods such as photoredox chemistry and electrosynthesis. This account focuses on novel methods for the generation of boryl and silyl radicals to forge C−B and C−Si bonds from our group. 相似文献
975.