Speech feature extraction method using subband-based periodicity and nonperiodicity decomposition

This paper proposes a speech feature extraction method that utilizes periodicity and nonperiodicity for robust automatic speech recognition. The method was motivated by the auditory comb filtering hypothesis proposed in speech perception research. The method divides input signals into subband signals, which it then decomposes into their periodic and nonperiodic components using comb filters independently designed in each subband. Both features are used as feature parameters. This representation exploits the robustness of periodicity measurements as regards noise while preserving the overall speech information content. In addition, periodicity is estimated independently in each subband, providing robustness as regards noise spectrum bias. The framework is similar to that of a previous study [Jackson et al., Proc. of Eurospeech. (2003), pp. 2321-2324], which is based on cascade processing motivated by speech production. However, the proposed method differs in its design philosophy, which is based on parallel distributed processing motivated by speech perception. Continuous digit speech recognition experiments in the presence of noise confirmed that the proposed method performs better than conventional methods when the noise in the training and test data sets differs.     

Relation of Photochemical Internalization to Heat,pH and Ca2+ Ions

The inefficient endosomal escape of drugs or macromolecules is a major obstacle to achieving successful delivery to therapeutic targets. An efficient approach to circumvent this barrier is photochemical internalization (PCI), which uses light and photosensitizers for endosomal escape of the delivered macromolecules. The PCI mechanism is related to photogenerated singlet oxygen, but the mechanism is still unclear. In this study, we examined the relation of PCI to heat, pH and Ca²⁺ ions using cell penetrating peptide (CPP)‐cargo‐photosensitizer (Alexa546 or Alexa633) conjugates. A cell temperature changing experiment demonstrated that heat (thermal mechanism) does not significantly contribute to the photoinduced endosomal escape. Inhibition of V‐ATPase proton pump activity and endosomal pH upregulation indicated that PCI‐mediated endosomal escape needs endosomal acidification prior to photoirradiation. Imaging of the CPP‐cargo‐photosensitizer and Ca²⁺ ions during photostimulation showed that intracellular calcium increase is not the cause of the endosomal escape of the complex. The increment is mainly due to Ca²⁺ influx. These findings show the importance of extra‐ and intracellular milieu conditions in the PCI mechanism and enrich our understanding of PCI‐related changes in cell.     

Substitution effects on olefin epoxidation catalyzed by Oxoiron(IV) porphyrin π-cation radical complexes: A dft study

The effects of peripheral fluorine atoms on epoxidation reactions of ethylene by oxoiron(IV) porphyrin cation radical complex in the quartet and sextet spin multiplicities are systematically investigated using the DFT method. The overall reaction routes are determined using a model system of ethylene and Fe(IV)OCl-porphyrin with substituted fluorine atoms. By obtaining the energy diagrams and electron- and spin-density difference contour maps of the transition states and intermediate compounds, we confirm that the electron-withdrawing by peripheral fluorine atoms enhances the reactivity as the number of fluorine atoms increases, as is observed experimentally. The intersystem crossing between the quartet and sextet spin multiplicities is discussed by means of the intrinsic reaction coordinate method. We conclude that the rate-determining step is located at the first transition state (TS1) for the activation of CC and FeO bonds, and the ground electronic state changes from quartet to sextet around the TS1. © 2019 Wiley Periodicals, Inc.     

Crystal structure and lattice vibration of proton dissolved BaZr0.8Sc0.2O2.9

Heat capacity and neutron diffraction measurements were carried out to determine the location of protons in the crystal of proton conducting perovskite oxide BaZr_0.8Sc_0.2O_2.9. The heat capacity of proton- and deuteron-dissolved BaZr_0.8Sc_0.2O_2.9 showed a slight difference from that of the dry sample. It indicates that the librational motion of the OH(OD) group is not excited below room temperature. The neutron diffraction experiments on the deutron dissolved sample indicate that the deuteron exists near the 12h site.     

Volumetric q-space imaging by 3D diffusion-weighted MRI

High b-value diffusion magnetic resonance imaging (MRI) enables us to detect far smaller architectures, by using q-space analysis, than the resolution in conventional MRI. Average displacement, one of the q-space parameters, quantitatively reflects architecture size and is very useful in observing small changes in microstructures in vivo (e.g., neurodegeneration, tumor heterogeneity, and others). Diffusion-weighted imaging (DWI) is performed by a two-dimensional (2D) multislice method; however, due to finite slice thickness and slice gap, there is a partial-volume effect that makes it difficult to detect the net q-space signal. On the other hand, three-dimensional (3D) MRI, having the advantages of very thin slice thickness and no slice gap (contiguous slices), allows volumetric evaluation acquired in a small isotropic voxel, as compared to 2D multislice imaging. Little is known about the isotropic high-resolution 3D DWI application to q-space analysis. In this study, we have developed and implemented a high b-value 3D DWI sequence, applied q-space analysis to study the reliability of high b-value 3D DWI and obtained a microscopic analytical map with isotropic high resolution and less contamination.     

Introduction of an arylthio(trimethylsilyl)methyl group into arenes by friedel-crafts reaction: synthesis of arylmethyltrimethylsilanes

Friedel-crafts reactions of [arylthio(chloro)methyl]trimethylsilanes (1a,b) with arenes gave [aryl(arylthio)methyl]trimethylsilanes (2a,b), which were converted into arylmethyltrimethylsilanes (3) by reduction with raney nickel.     

Oxidative fragmentation of γ-hydroxyalkyl stannanes stereospecific formation of (e) and (z)-keto olefins

Treatment of γ-hydroxyalkyl stannanes with lead tetraacetate in refluxing benzene leads to the stereospecific formation of (E) and (Z)-keto olefins according to the stereochemistry of the starting materials in excellent yield.