Synthesis and Anti-inflammatory Activity of a Novel Series of 9,10-Dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one Derivatives

Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity,while some 1,3-benzoxazine derivatives show anti-inflammatory activity.In order to explore the novel anti-inflammatory agents,based on the principles of bioisosterism and hybridization,ten novel chromeno[8,7-e][1,3]oxazin-4-ones were synthesized and characterized with IR,1H NMR,MS and elemental analyses.The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema tes...     

The Renner effect in triatomic molecules with application to CH+, MgNC and NH2

We have developed a computational procedure, based on the variational method, for the calculation of the rovibronic energies of a triatomic molecule in an electronic state that become degenerate at the linear nuclear configuration. In such an electronic state the coupling caused by the electronic orbital angular momentum is very significant and it is called the Renner effect. We include it, and the effect of spin-orbit coupling, in our program. We have developed the procedure to the point where spectral line intensities can be calculated so that absorption and emission spectra can be simulated. In order to gain insight into the nature of the eigenfunctions, we have introduced and calculated the overall bending probability density function f(p) of the states. By projecting the eigenfunctions onto the Born-Oppenheimer basis, we have determined the probability density functions f+(rho) and f-(rho) associated with the individual Born-Oppenheimer states phi(-)elec and phi(+)elec. At a given temperature the Boltzmann averaged value of the f(p) over all the eigenstates gives the bending probability distribution function F(rho), and this can be related to the result of a Coulomb Explosion Imaging (CEI) experiment. We review our work and apply it to the molecules CH2+, MgNC and NH2, all of which are of astrophysical interest.     

Salting-out and ionic volume behavior of some tetraalkylammonium salts

Measurements of salting-out of Ar by NH ₄ Br and a series of homologous symmetrical tetraalkylammonium bromides in water are reported and discussed. A new gas-solubility apparatus is used enabling the solubility to be derived from a number of measurements on the same gas-solution sample at various pressures, rather than from a single measurement on each solution. Unexpectedly large salting-out effects are observed which increase with cation size. Electrostatic and nonelectrostatic effects are examined in relation to the ionic-volume behavior in water and methanol as a basis for discussion of the results. The relative electrostrictions of the TAA and Br^? ions in these two solvents are compared. Calculations based on electrostatic and scaled particle theory are compared, and it is concluded that the latter treatment obscures the electrochemical factors of essential interest in solute/solvent distribution about ions in solution.