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101.
102.
Anna A. Rugal Vladimir M. Gun’ko Valentina N. Barvinchenko Vladimir V. Turov Tatyana V. Semeshkina Vladimir I. Zarko 《Central European Journal of Chemistry》2007,5(1):32-54
Interaction of human plasma fibrinogen (HPF) with fumed nanosilica A-300 in a phosphate buffer solution (PBS) was studied
using 1H NMR spectroscopy with layer-by-layer freezing-out of bulk and interfacial water in the temperature range of 210–273 K, TSDC
(90 < T < 265 K), adsorption, FTIR, and UV spectroscopy methods. An increase in concentration of HPF in the PBS leads to a decrease
in amounts of structured water (frozen at T < 273 K) because of coagulation of HPF molecules. Addition of nanosilica to the HPF solution strongly reduces the amounts
of structured water because of adsorption interaction of HPF molecules with silica nanoparticles, self-association of HPF
molecules, formation of denser packed hybrid agglomerates with HPF and silica, and lastly, because of conformational changes
of HPF. A monolayer adsorption capacity of A-300 corresponds to 156 mg of HPF per gram of silica. The FTIR and UV spectra
show that the HPF adsorption on silica leads to structural changes of the protein molecules. These changes and formation of
hybrid HPF/A-300 aggregates can increase the rate of clotting that is of importance on nanosilica application as a component
of tourniquet preparations.
相似文献
103.
Mitkina T Fedin V Llusar R Sorribes I Vicent C 《Journal of the American Society for Mass Spectrometry》2007,18(10):1863-1872
Electrospray ionization mass spectrometry makes it possible to generate gas-phase bis-ethylenediamine nickel and copper dications, [M(en)(2)](2+) (M = Ni, 1; M = Cu, 2), as well as their {[M(en)(2)]@cuc[8]}(2+) inclusion complexes with the macrocyclic cavitand cucurbit[8]uril (cuc[8]). The unimolecular gas-phase reactivity of these species has been investigated by electrospray ionization tandem mass spectrometry with a quadrupole-time-of-flight configuration. Distinctive fragmentation pathways have been observed for the free and encapsulated [M(en)(2)](2+) (M = Ni, Cu) dications under collision-induced dissociation (CID) conditions. The dications [M(en)(2)](2+) (M = Ni, Cu) dissociate according to several competitive pathways that involve intra-complex hydrogen or electron-transfer processes. Most of these channels are suppressed after encapsulation inside the cucurbit[8]uril macrocycle and, as a consequence, a simplification of the {[M(en)(2)]@cuc[8]}(2+) fragmentation pattern is observed. The results obtained demonstrate that the encapsulation of a coordination complex inside a host molecule can be used to alter the nature of the product ions generated under CID conditions. 相似文献
104.
Walmsley JA Zhu S Matilla A Donowick TG Cramp JE Tercero JM Dalrymple T 《Inorganic chemistry》2007,46(23):9945-9953
Cyclic tetrameric complexes have been prepared by the reaction of Pd(en)Cl2 or Pd(dapol)Cl2, or their nitrato analogues, with Na2(5'GMP) in aqueous solution, where en=1,2-diaminoethane, dapol=1,3-diamino-2-propanol, and 5'GMP=guanosine 5'-monophosphate. Addition of certain small molecules containing hydrophobic groups resulted in the expansion of the tetramer to a cyclic hexamer with strong bonding of one guest per hexameric host. At pH 5-6, the guest molecule can be a cation, anion, or neutral, and those species containing trimetylsilyl and t-butyl groups bonded the most strongly. The size of the central cavity of the [Pd(en)(5'GMP)]6 host has been estimated to be 5.2 A. Formation of the host-guest complex caused a large upfield shift (Deltadelta) of 2.5-2.9 ppm in the 1H NMR spectrum of the most highly affected guest protons, which were those in closest proximity to the guanine nucleobases. NOESY spectra were used to determine the interaction sites between the host and the guest. Apparent association constants determined at 26 degrees C and pD 5.4 for the [Pd(en)(5'GMP)]6-DSS and [Pd(en)(5'GMP)]6-t-butanol systems, where DSS is 3-(trimethylsilyl)-1-propanesulfonate anion, were 1.36+/-0.11x10(4) and 2.74+/-0.95x10(4) M(-3/2), respectively. The Pd(dapol)-5'GMP system forms hexameric host-guest complexes, similar in nature to those of the Pd(en)-5'GMP system. The molecular and crystal structures of Pd(dapol)Cl2 are also reported. 相似文献
105.
Larina LI Elokhina VN Yaroshenko TI Nakhmanovich AS Dolgushin GV 《Magnetic resonance in chemistry : MRC》2007,45(8):667-673
Novel 2-acetylamino-4-acetyl-5-aryl(heteryl)-1,3,4-thiadiazolines, 2-acetylamino-5-aryl(heteryl)-1,3,4-thiadiazoles, and some of their salts were prepared and studied by multinuclear 1H, 13C, 15N, 19F and 2D NMR spectroscopy. The acetylation of thiosemicarbazones is accompanied by ring closure to form the corresponding 1,3,4-thiadiazolines and 1,3,4-thiadiazoles. 15N NMR spectroscopy is a unique method for the identification of thiadiazole pyridinium salts. 相似文献
106.
da Silva EF Kuznetsova T Kvamme B Merz KM 《The journal of physical chemistry. B》2007,111(14):3695-3703
Molecular dynamics simulations have been carried out for ethanolamine as a pure liquid and in aqueous solution at 298 and 333 K. The ethanolamine force field has been parametrized to reproduce intramolecular energies from quantum mechanical calculations and experimentally determined properties of the liquid. The results are presented for conformer distributions, density, enthalpy of vaporization, self-diffusion constant, dielectric constant, and radial distribution functions. The results strongly suggest that the main (O-C-C-N) dihedral tends to stay in its gauche conformers in solution and that the ethanolamine molecules populate conformers with a significant degree of intramolecular hydrogen bonding. This result is also supported by results from a continuum solvation model. Simulation of a 10 mol % aqueous ethanolamine system suggests that ethanolamine is preferentially solvated to by water molecules. The results suggest that ethanolamine dimer formation in aqueous solution is very limited. Simulations were also carried out for CO2 in an aqueous ethanolamine system. The results suggest that CO2 has a comparable level of attraction to ethanolamine and water. The degree of interaction between CO2 and the amine and alcohol functionalities in ethanolamine also appear to be of comparable strength. 相似文献
107.
Sergey Francevich Vasilevsky Olga Leonidovna Krivenko Irina Vasilievna Sorokina Dmitry Sergeevich Baev Tatyana Genrikhovna Tolstikova Igor V. Alabugin 《Molecules (Basel, Switzerland)》2021,26(22)
The interaction of acetamidine and phenylamidine with peri-R-ethynyl-9,10-anthraquinones in refluxing n-butanol leads to the formation of cascade transformations products: addition/elimination/cyclization―2-R-7H-dibenzo[de,h]quinolin-7-ones and(or) 2-R-3-aroyl-7H-dibenzo[de,h]quinolin-7-ones. The anti-inflammatory and antitumor properties of the new 2-R-7H-dibenzo[de,h]quinolin-7-ones were investigated in vivo, in vitro, and in silico. The synthesized compounds exhibit high anti-inflammatory activity at dose 20 mg/kg (intraperitoneal injection) in the models of exudative (histamine-induced) and immunogenic (concanavalin A-induced) inflammation. Molecular docking data demonstrate that quinolinones can potentially intercalate into DNA similarly to the antitumor drug doxorubicin. 相似文献
108.
Alexander L. Rusanov Ludmila G. Komarova Tatyana S. Sheveleva Marina P. Prigozhina Svyatoslav A. Shevelev Michai L. D. Dutov Irina A. Vatsadze Olga V. Serushkina 《Macromolecular Symposia》1997,122(1):123-128
New aromatic diamines were obtained on the basis of available and inexpensive 2, 4, 6-trinitrotoluene (trotyl, TNT). Monomers obtained were used for the preparation of the new organo-soluble polyimides containing thiophenoxy and phenoxy side groups. 相似文献
109.
110.