Heartwood of Dalbergia cochinchinensis: 4,7,2′-Trihydroxy-4′-methoxyisoflavanol and 6,4′-Dihydroxy-7-methoxyflavane Reduce Cytokine and Chemokine Expression In Vitro

Dalbergia cochinchinensis has been widely used in traditional medicine because of its flavonoids; however, the impact of the flavonoids to modulate the inflammatory response to oral cells remains to be described. For this aim, we isolated 4,7,2′-trihydroxy-4′-methoxyisoflavanol (472T4MIF) and 6,4′-dihydroxy-7-methoxyflavane (64D7MF) from the heartwood of D. cochinchinensis and confirmed the chemical structure by nuclear magnetic resonance. We show here that both flavonoids are inhibitors of an inflammatory response of murine RAW 264.7 inflammatory macrophages stimulated by LPS. This is indicated by interleukin (IL)1, IL6, and chemokine CCL2 production besides the phosphorylation of p65. Consistently, in primary murine macrophages, both flavonoids decreased the inflammatory response by lowering LPS-induced IL1 and IL6 expression. To introduce oral cells, we have used human gingival fibroblasts and provoked the inflammatory response by exposing them to IL1β and TNFα. Under these conditions, 472T4MIF, but not 64D7MF, reduced the expression of chemokines CXCL1 and CXCL2. Taken together, we identified two flavonoids that can reduce the expression of cytokines and chemokines in macrophages and fibroblastic cells.     

Dipolar Glass Polymers for Capacitive Energy Storage at Room Temperatures and Elevated Temperatures

Dielectric polymers are the materials of choice for high energy density film capacitors. The increasing demand for advanced electrical systems requires dielectric polymers to operate efficiently under extreme conditions, especially at elevated temperatures. However, the low permittivity and relatively low operating temperature of dielectric polymers limit the high-temperature capacitive energy storage applications.Fortunately, dipolar glass polymers are demonstrated as the preferred materials to...     

SYMPLECTIC COMPUTATION OF HAMILTONIAN SYSTEMS (I)

AbstractWe get τ6-terms of the formal energy of the mid-point rule, and use the mathematical pendulum to test the convergence of the formal energy.     

保单个数为Poisson分布的总理赔额分布函数的界值研究

根据单个保单理赔额分布函数F(z)的一些特殊性质,研究了开放个别风险模型在保单个数N为Poisson分布下,总理赔额分布函数F_S(x)对任意x(x≥0)的界值问题,得到一些实用的、便于数值计算的界值结果,具有重要的应用价值．     

A local strict comparison theorem and converse comparison theorems for reflected backward stochastic differential equations

A local strict comparison theorem and some converse comparison theorems are proved for reflected backward stochastic differential equations under suitable conditions.     

投资连结型寿险的初始准备金和定价

利用VaR思想并根据保险人风险收益,在初始准备金收益率固定或随机的情况下,讨论了具有养老金性质的投资连结保单的初始准备金和定价,并进行了模拟计算.     

基于三维简并四波混频的PDT光敏剂HA瞬态光栅特性研究

竹红菌甲素(hypocrellin A,HA)具有丰富的激发态特性,有可能在新型光动力疗法(PDT)光敏剂、激光染料和新型光电器件方面有一定的应用前景。利用瞬态光栅技术研究了竹红菌甲素分别在不同极性和粘度溶剂中以及溶剂本身的瞬态光栅特性,把其瞬态光栅的超快过程归结为竹红菌甲素质子转移形成的过渡态TS*的衰减,得出过渡态TS*瞬态光栅的寿命为10.5 ps。竹红菌甲素分子的质子转移过渡态TS*瞬态光栅寿命不受溶剂极性和粘度的影响。     

大气风场探测萨尼亚克干涉仪光程差的计算及探测模式研究

提出了基于时空混合调制的大气风场探测模式;应用光线追迹方法推导了一种改型萨尼亚克干涉仪在任意角入射时的光程差;从理论上对该干涉仪的参量作了分析计算;通过对同种、异种材料组合的理论分析,得出了异种材料组合的改型萨尼亚克干涉仪更加适合高层大气风场探测。该干涉仪具有稳态、大视场、大光程差、时空混合调制探测模式等显著特点。该研究发展了高层大气风场的被动探测理论,对风场探测技术研究、探测模式和工程化都具有十分重大的理论及实践意义。     

Experimental Study of Hygrothermal and Ultraviolet Aging on the Flexural Performance of Epoxy Polymer Mortar

This paper studies the effects of hygrothermal environment at different tempera-tures and ultraviolet(UV)radiation on the bending properties of epoxy polymer mo...     

会聚光在柱状模拟生物组织中的实验研究

在中空的柱状有机玻璃中充入Intralipid-10%溶液构成单层圆柱模拟样品.在会聚单色光入射Intralipid-10%溶液的情况下,利用特制的光纤探头、锁相放大器、斩波器和微动平台等组成测试装置,测量了柱状Intralipid-10%溶液内后向散射光、能流率的空间分布情况,并对测量结果进行分析.对参量不同的溶液中的光分布进行了比较,得出了柱状溶液中光分布的初步规律.