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971.
Takeshi Fukushima Emi Naka-aki Famei Li Willy R.G. Baeyens Toshimasa Toyo’oka 《Analytica chimica acta》2004,522(1):99-104
Fluoxetine (FLX) and the N-desmethyl metabolite, norfluoxetine (NFLX) in rat brain microdialysis samples were determined by high-performance liquid chromatography (HPLC) with fluorescence detection using pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). In vitro experiment showed that the relative recovery of FLX across microdialysis membrane was enhanced by adding β-cyclodextrin (β-CD) or β-CD polymer to microdialysis perfusion fluid. The perfusion fluid containing β-CD polymer, which has polymeric glyceryl linkers attached to the hydroxyl group, gave the better recovery with satisfactory precisions. Using 1% β-CD polymer in Ringer’s solution as the perfusate, in vivo rat brain microdialysis experiment on intraperitoneal administration of FLX (10 mg/kg) to rats was carried out. The fluorescence peaks of FLX and NFLX appeared later than 30 min after the administration of FLX, and then, gradually increased with time. Two hours later, FLX reached a plateau level, but NFLX slowly increased, and at 24-48 h, NFLX levels were higher than FLX levels. These data suggest that long distributions of FLX and the potent metabolite, NFLX, in brain contributed to the long-term drug actions in vivo. 相似文献
972.
A novel ABA-type triblock copolymer, where A and B correspond to azobenzene (Az) containing polymethacrylate and poly(ethylene oxide) (PEO), respectively, was synthesized by atom transfer radical polymerization. Langmuir-Blodgett monolayers showed characteristic microphase separation structures depending on the isomerization state of the Az unit. The trans-to-cis isomerization induced an anisotropic elongation of the domain of the Az polymer parallel to the rod maintaining the width. Thus, successful photocontrol of nanostructures formed by the block copolymer in the two dimensions was performed. A plausible model for the Az packing and PEO conformation is proposed. 相似文献
973.
Treatment of thiol esters 1 with zinc reagent 2 in the presence of a small amount (相似文献
974.
A novel method for the synthesis of oligoribonucleotides using 1-(2-cyanoethoxy)ethyl (CEE) as a 2′-hydroxy protecting group has been developed. A CEE group was introduced to the 2′-position of N-acyl-3′,5′-O-silyl-protected ribonucleosides under acidic conditions in good yields. The 2′-O-CEE group was found to be stable in an aqueous or ethanolic ammonia and was quickly removed by treatment with anhydrous tetrabutylammonium fluoride (TBAF). A combination of the use of N-acyl and 2′-O-CEE protecting groups enabled a reliable and complete two-step deprotection, first with NH3–EtOH, then with TBAF in THF, without cleavage of internucleotidic linkages. 相似文献
975.
Masahiro Kurakake Takeshi Shirasawa Hiroshi Ooshima Alvin O. Converse Jyoji Kato 《Applied biochemistry and biotechnology》1995,50(3):231-241
Three empirical rate expressions, Kinetics I, II, and III, for the enzymatic hydrolysis of cellulose were evaluated in an
effort to develop a easy-to-use rate expression. They are based on the following equation:-dV/dX = kV, where V and X are the hydrolysis rate and the fractional conversion. In Kinetic I,k is constant. In Kinetic II, a linear relatinship betweenk and t is assumed. In Kinetic III, an exponential relationship is assumed. The three expressions were applied to enzymatic
hydrolysis carried out under seven different conditions in which the kinds of substrates, enzymes, and initial concentrations
were varied. All of the examined rate expressions were applied to the hydrolysis with success, but the better accuracies were
obtained by Kinetic III, Kinetic II, and Kinetic I in this order. The variations ofk with time found in this study, especially the exponential relationship, were consistent with the effect of the measured changes
in the concentration of adsorbed enzyme as predicted by theory developed previously by Ooshima et al. (1). 相似文献
976.
脂环族环氧树脂和螺环原碳酸酯的光引发正离子共聚合 总被引:2,自引:0,他引:2
<正> 无收缩单体-1,6,8,13-四氧螺[7,7]十三碳烷(SOC_7)和3,4-环氧基环己烷甲酸3',4'-环氧基环己烷甲酯(ERL-4221)的光引发正离子共聚合的研究结果表明,少量SOC_7加到ERL-4221体系中可抑制固化收缩没有明显降低热性能。ERL-4221对SOC_7的合适克分子比为4比1,由此得到T_g为203℃而聚合时体积收缩为4.4%的交联共聚物。 相似文献
977.
We present rigorous correlation inequalities for connectedn-point functions in a class of even ferromagnets. The class includes spin-1/2 Ising models and scalar field models with potential functionV which is even and continuously differentiable withV convex on [0, ). These inequalities are obtained by pushing ahead with the method of Ellis, Monroe, and Newman at its maximum. 相似文献
978.
Kazuhiko Sakaguchi Masahiro Yamamoto Takeshi Yamada Keiko Shimamoto 《Tetrahedron letters》2004,45(30):5869-5872
The synthesis of four types of optically active β-carbon-substituted analogs of threo-β-hydroxy aspartate (THA) and a β-carbon-substituted analog of threo-β-benzyloxy aspartate (TBOA), which are potent blockers of excitatory amino acid transporters in the mammalian central nervous system, via the chirality-transferring ester-enolate Claisen rearrangement of α-acyloxytrialkylsilane is described. 相似文献
979.
Abstract Vermiculite and fluor-tetrasilicic mica were intercalated with alkali metals (Na, K and Rb) by vapor transport. X-ray and Raman scattering experiments were conducted to study the structure and lattice dynamics of the new clay compounds. When Rb and K atoms were intercalated to the host materials, superlattices were formed. In Na intercalated compounds, however, no superlattice x-ray diffraction peaks were found. Raman spectra exhibited drastic changes after alkali-metal intercalation, reflecting the structural changes found by our x-ray diffraction. 相似文献
980.