Glucuronate-modified liposomes with prolonged circulation time

For the purpose of obtaining liposomes with long circulation time in blood, we synthesized 1-O-palmityl-D-glucuronic acid (PGlcUA) and incorporated it into the liposomal membranes. The clearance of the PGlcUA-liposomes composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol, and PGlcUA (40:40:20 as a molar ratio) from blood and their tissue distribution were compared with those of dipalmitoylphosphatidylglycerol (DPPG)-liposomes (DPPC/cholesterol/DPPG = 40:40:20). When [3H]inulin-loaded PGlcUA-liposomes and DPPG-liposomes were intravenously injected into rats, the half-life of the PGlcUA-liposomes in the blood appeared to be 1.7-fold longer than that of DPPG-liposomes. Radioactivities present in plasma and various tissues were measured 22 h after administration of these liposomes, and radioactivity remaining in the plasma was 2.5-fold greater when PGlcUA-liposomes were injected. The distribution pattern of [3H]inulin in PGlcUA-liposomes was similar to that in DPPG-liposomes. The radioactivity recovered in urine was 25% lower in rats treated with PGlcUA-liposomes than in those treated with DPPG-liposomes. Since both PGlcUA- and DPPG-liposomes exhibited similar size distribution and zeta-potential, glucuronic acid, rather than negative charge, on the liposomal surface appears to endow liposomes with a longer circulation time in the bloodstream.     

New approach to the practical synthesis of tri- or tetrasubstituted pyrimidine derivatives: a four-component coupling reaction from a functionalized silane, two types of aromatic nitriles, and acetals

[reaction: see text] A new approach to the synthesis of tri- or tetrasubstituted pyrimidines by a four-component coupling reaction using a functionalized silane, two types of aromatic nitriles, and an acetal is described. The efficient transformation of the pyrimidine framework consisting of an isoxazolyl ring and an ethoxy group to the 1,3,8-triazanaphthalene skeleton also proceeded in nearly quantitative yield.     

Photorefractive effect in composites of ferroelectric liquid crystal and photoconductive polymer

The photorefractive effect in composites of a ferroelectric liquid crystal (FLC) and several photoconductive polymers was investigated. The photorefractivity of mixtures of photoconductive polymers and an FLC (polymer/FLC), as well as that of photoconductive-polymer-stabilized ferroelectric liquid crystals (PPS-FLCs) was examined. The polymer/FLC samples exhibited two-beam coupling gain coefficients of about 6∼12 cm^-1 in a 5 µm gap cell. The photopolymerization of a methacrylate monomer in the FLC medium established a polymer-stabilized state in which the alignment of FLC molecules was mechanically stabilized. The noise in a two-beam coupling signal was reduced significantly in the PPS-FLC samples.     

Crystal forms and ferroelectric properties of poly(vinylidene fluoride)/polyamide 11 blends prepared by high‐shear processing

Nanostructured poly(vinylidene fluoride) (PVDF)/polyamide 11 (PA11) blends have been melt‐processed using a high‐shear extruder. Uniaxially oriented blended films were fabricated by hot rolling to prepare ferroelectic films. The effects of rolling temperature and draw ratio on the crystal forms of both PVDF and PA 11 were investigated by means of Fourier transform infrared spectra (FTIR) and wide‐angle X‐ray diffraction (WAXD). It was shown that hot rolling in the range of 25–110 °C results in the crystal form transformation from the nonpolar α‐form into the polar β‐form for PVDF. The content and orientation function of β‐crystallites are strongly dependent upon the rolling temperature and the draw ratio. The highest content of well‐oriented β‐crystallites was achieved with a draw ratio of 4.0 upon rolling at 80 °C. At the same time, the content of the α‐form of PA11 in the blend was also found to decrease by hot rolling. The ferroelectric properties (D‐E hysteresis) of the oriented blended films were measured. The remanent polarization of the PVDF/PA11 = 90/10 blend is as high as 91 mC/m², which is about 1.2 times higher than that of pure PVDF. The D‐E hysteresis curves and the temperature dependence of the piezoelectric stress coefficients of the high‐shear‐processed sample suggested that the formation of nano‐dispersed structures resulted in the improvement of the remanent polarization and thermal characteristics at a temperature higher than 80 °C. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 2707–2714, 2007     

A pegging approach to the precedence-constrained knapsack problem

The knapsack problem (KP) is generalized to the case where items are partially ordered through a set of precedence relations. As in ordinary KPs, each item is associated with profit and weight, the knapsack has a fixed capacity, and the problem is to determine the set of items to be packed in the knapsack. However, each item can be accepted only when all the preceding items have been included in the knapsack. The knapsack problem with these additional constraints is referred to as the precedence-constrained knapsack problem (PCKP). To solve PCKP exactly, we present a pegging approach, where the size of the original problem is reduced by applying the Lagrangian relaxation followed by a pegging test. Through this approach, we are able to solve PCKPs with thousands of items within a few minutes on an ordinary workstation.     

Colorimetric recognition of the length of α,ω-diamines in water

Two types of host molecules based on phenolphthalein and two crown ethers have been constructed. These hosts made it possible to recognize the length of α,ω-diamines and transformed the binding events into detectable changes in color in an aqueous buffer solution.     

A Siegel modular threefold and Saito-Kurokawa type lift to <Emphasis Type="Italic">S</Emphasis><Subscript>3</Subscript>(Γ<Subscript>1,3</Subscript>(2))

Hulek and others conjectured that the unique differential three-form F (up to scalar) on the Siegel threefold associated to the group Γ_1,3(2) comes from the Saito-Kurokawa lift of the elliptic newform h of weight 4 for Γ₀(6). This F have been already constructed as a Borcherds product (cf. Gritsenko and Hulek in Int Math Res Notices 17:915–937, 1999). In this paper, we prove this conjecture by using the Yoshida lift and we settle a conjecture which relates our theorem. A remarkable fact is that the Yoshida lift using the usual test function cannot give the Saito-Kurokawa type lift of weight 3 associated to the group Γ_1,3(2). So important task is to find special test functions for the Yoshida lift at the bad primes 2 and 3. Dedicated to Professor Tomoyoshi Ibukiyama on his 60th birthday.     

Cosmic-ray positron from superparticle dark matter and the PAMELA anomaly

Motivated by the anomalous positron flux recently reported by the PAMELA Collaboration, we study the cosmic-ray positron produced by the pair annihilation and the decay of superparticle dark matter. We calculate the cosmic-ray positron flux and discuss implications of the PAMELA data. We show that the positron excess observed by the PAMELA can be explained with some of the superparticle dark matter.