水雾中声波传播衰减问题的实验研究

本文首先介绍了利用混响室对水雾中低频声波衰减情况的实验研究。实验结果一方面表明,在低频段(<100Hz)水雾中质量弛豫过程将对声波的吸收造成明显的影响;另一方面还表明,即使是在低频区,水雾中声波的衰减随频率的上升仍然是增加的,这符合现有理论的变化趋势,但与以往公认的经典Knudsen实验结果不一致。文章中还介绍了在小管道内利用脉冲回波法和超声成雾方法,对水雾中声衰减所进行的测量。实验结果表明,当水雾中水滴半径缩小时,水雾中的质量弛豫过程将向高频区发生移动,这一现象又为有关作者所忽视。     

Investigation of Microemulsion System for Transdermal Drug Delivery of Amphotericin B

In order to solve the drawback of poor bioavailability by the oral route and infusion-related side effect for Amphotericin B(AmB), microemulsion vehicles composed of isopropyl myristate(IPM), Tween 80, isopropyl alcohol and water for transdermal delivery of AmB were designed. The pseudo-ternary phase diagrams were constructed by the H2O titration method and the structures of the microemulsion were determined by measuring electrical conducti-vities(σ). The diffusion studies of AmB microemulsion were performed via excised rabbit skin on a drug diffusion apparatus. To obtain a high solubization of AmB, three different methods were tested to incorporate AmB into mi-croemulsion. The result suggests adding AmB in the shape of NaOH solution to the O/W blank microemulsion over the phase inversion temperature(PIT) of the emulsifier obtains the maximum drug content(2.96 mg/mL). The pH value of the system could be adjusted to pH8.5 or pH<5.2, in this range AmB molecules converts from aqueous to the hydrophilic shell of the microemulsion droplets, drug precipitate is no more than 5%, and the formulations were corresponding to the characterizations of microemulsion. At pH 5.14, AmB microemulsion with Km 1:1, O/SC 1:9(mass ratio ofoil phase to surfactant/cosurfactant blend), water content 64.6%, drug content (2.93±0.08) mg/mL,showed the maximum permeation rate(3.255±0.64)μg·cm-2·h-1,which is stable for a long time.     

F_m∨P_n的点可区别边色数

研究了Fm∨Pn的点可区别边染色,给出了Fm∨Pn的点可区别边色数.     

数学软件在数学教学中的应用——数学实验一例

介绍了利用数学软件mathematica 5.0强大功能进行多媒体教学的一个案例,尝试了以实验、探索、发现为特征的启发式教学模式,它符合人类的认知规律,对提高课堂教学质量有一定的效果.     

聚类分析分类结果合理性考核方法

对聚类分析应用于肿瘤分型时的分类结果合理性考核方法进行探讨.该方法借助于预测强度指标,并结合中位数及95%参考值范围的概念来比较不同聚类方法得到的分类的合理性,在一定程度上弥补了聚类分析方法的应用不足.在对白血病患者分型时取得了很好的效果.     

Molecular Design and Immunogenicity of a Multiple-epitope FMDV Antigen and DNA Vaccination

This article reports the design and construction of a multiple-epitope foot and mouth disease virus （FMDV） antigen, designated as OAAT. This recombinant antigen consists of the structural protein VP1 genes from serotypes A and O FMDV, five major VP1 immunodominant epitopes from two genotypes of Asial serotype, and three Th2 epitopes originating from the nonstructural protein, three ABC gene and structural protein VP4 gene. Expressions of target gene from these plasmids in HeLa cells were verified by Western-blot. BALB/c mice were immunized intramuscularly with the DNA vaccines thrice every two weeks. We found that pA could induce simultaneously specific antibodies against serotypes A, Asial, and O FMDV. Compared to those of the controls, the spots of FMDV-specific IFN-7 and cytotoxic activity from mice immunized with pA were significantly increased, pA provided full protection in 2/4 guinea pigs from challenge with FMDV O/NY00 and Asial/YNBS/58, respectively. The results show that although pA did not give full protection in 100% immunized guinea pigs from challenge with type O and Asial FMDV, respectively, OAAT may be potential immunogen against FMDV and pA may be potential DNA vaccines against FMDV.     

无穷方差厚尾过程变点的小波估计

研究随机设计下噪声为厚尾随机变量时非参数函数中的变点估计问题.首先,通过设计变换将随机设计转化为等间距固定设计,进而利用小波方法估计变换后的变点的位置,再利用逆设计变换求得随机设计下变点位置的估计,并给出估计的收敛速度.模拟研究结果说明对于无穷方差厚尾过程中的变点估计问题小波方法是有效的.     

状态转变增强拉曼光谱

表面增强拉曼散射(SERS)是公认的超灵敏的光谱工具.和传统的优化SERS基底材料或构筑完美的结构策略相比,我们提出了一种极其简单和灵敏的方法,该方法被命名为状态转变增强拉曼光谱(STERS).这种STERS检测方法可广泛的应用于毒品安全检测、食品安全和环境保护等方面.如果我们把这种方法和便携式拉曼光谱仪结合,这种应用...