New chiral catalysts: synthesis and fragmentation pattern of C9-o-silanized cinchonidines

Summary We synthesized C9-O-silyl ethers of cinchonidine and dihydrocinchonidine (1-8), seven of which have not been known before. The structures of the compounds were verified by ESI-ion-trap MS and ¹H-NMR. Fragmentation of silyl ethers containing Si-phenyl bonds was studied for the first time. The compounds obtained will be utilized as chiral catalysts of certain asymmetric syntheses.</o:p>     

Die Papierelektrophorese von Phenolen

Zusammenfassung Es wird über die Papierelektrophorese ein-und mehrwertiger teilweise auch substituierter Phenole sowie einiger saurer Kupplungskomponenten für Azofarbstoffe berichtet. Nachweismittel und Wanderungsweiten unter vergleichbaren Versuchsbedingungen werden angegeben, desgleichen wird versucht, Zusammenhänge zwischen Konstitution und Laufweite zu finden.DiplomarbeitI. Szabolcs, Techn. Hochschule, Wien 1959.     

Identification of oxo,epoxy and somecis-carotenoids in high-performance liquid chromatography

Summary Methods of identification of aldehyde, ketonic, 5,6-epoxy, 5,8-epoxy groups andcis double bonds with highcis-peaks in carotenoids in HPLC have been investigated with selected models and a plant extract.     

On a problem of Erdős and Graham

In this paper we provide bounds for the size of the solutions of the Diophantine equation

$$\begin{aligned} x(x+1)(x+2)(x+3)(x+m)(x+m+1)(x+m+2)(x+m+3)=y^2, \end{aligned}$$

where \(4\le m\in \mathbb {N}\) is a parameter. We also determine all integral solutions for \(1\le m\le 10^6.\)

     

Preparation of benzoate esters of morphine and its derivatives

Abstract  

Sustained analgesia is crucial for patients suffering from long-acting pain. Ester derivatives of morphine could enhance the lipophilicity of morphine; consequently its transdermal delivery as well as its duration of action are also increased. Therefore, twenty-one 3-O-, 6-O-, and 14-O-benzoate esters of morphine and their derivatives were synthesized in order to elaborate different synthetic methods suitable for esterification of these widely used compounds. Schotten–Baumann reaction was applied with sodium hydrogen carbonate, triethylamine, or pyridine in methylene chloride or 1,2-dichloroethane as solvents. The presence of 4-dimethylaminopyridine catalyst was also successfully utilized mainly in the case of tertiary alcohols. A novel synthesis of dihydromorphine via diacetyl morphine free of by-products is also presented. Structures of all synthesized compounds were elucidated by ¹H nuclear magnetic resonance (NMR), ¹³C NMR, high-resolution mass spectrometry (HRMS), and electron ionization mass spectrometry (EI-MS). The log D (pH 7.4) values of the synthesized compounds were determined by a reversed-phase high-performance liquid chromatography (HPLC)–MS-based method, and calculated hydrolysis rate constants are also provided. The synthesized benzoate esters are potential prodrugs of the parent morphine with enhanced lipophilicity, derivatives which can also be used in transdermal drug delivery as prospective long-acting narcotic analgesics.     

Fire Retarded Insulating Sheets from Recycled Materials

In this work we aimed at forming partially recycled polymer composites of appropriate mechanical properties and flame retardancy. Multilayer composite structures proved to be suitable to fulfill all of these requirements. Core-shell structures presented here contain two-component thermosets, i.e. epoxy, recycled polyurethane and polyisocyanurate, as matrices reinforced with waste fillers such as short basalt fibers and wood chips. Flame retardancy and mechanical properties of the core-shell structures were investigated by the conventional methods of characterization. The developed cost-effective multilayer composites can be applied as heat and sound insulating panels e.g. multifunctional sheets for construction or automotive industry.     

Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.