The oral administration of MnCl2: A potential alternative to IV injection for tissue contrast enhancement in magnetic resonance imaging

Mn⁺² (as MnCl₂) was administered to rabbits intravenously and orally (a route of administration which based upon our previous experiments in rats⁷ promises to give selective hepatobiliary enhancement with less systemic toxicity). Nuclear magnetic relaxation dispersion or T₁ (NMRD) was performed on selected tissues (heart, liver, kidney, serum, and bile) in both animal groups to examine possible qualitative and semiquantitative differences in T₁ relaxation at equivalent sacrifice times. One animal was given an oral dose of MnCl₂ (620 micromoles/kg) and imaged sequentially (T₁ weighted sequence, .12T) for 30 minutes. The NMRD curves for organ tissues show an increase in relaxation efficacy in the 10–20MHz range characteristic of Mn-macromolecular complexes and are similar irrespective of the route of administration. The lack of increased relaxation enhancement for bile in this frequency range reflects cleavage of this complex upon excretion. Decreased overall relaxation in the liver is observed when oral Mn⁺² is compared to IV Mn⁺² due to the small fraction of administered dose that is absorbed. However, the images document a significant increase in the intensity of liver signal after the oral dose. We suspect this dose may ultimately be adjusted downward to give selective hepatobiliary effects.     

Stochastic perturbation of non-Kerr law optical solitons

The dynamics of optical solitons with non-Kerr law non-linearities, in presence of stochastic perturbation terms, is studied in this paper. The Langevin equations are derived and it is proved that the solitons travel through a fiber with a fixed mean velocity. The non-linearities that are considered here are the power law, parabolic law and the dual-power law types.     

Soliton Perturbation Theory for the Compound KdV Equation

The soliton perturbation theory is used to study the solitons that are governed by the compound Korteweg de-Vries equation in presence of perturbation terms. The adiabatic parameter dynamics of the solitons in presence of the perturbation terms are obtained. AMS Codes: 35Q51; 35Q53; 37K10. PACS Codes: 02.30.Jr; 02.30.Ik.     

Incoherently coupled screening photovoltaic spatial solitons in biased photovoltaic photorefractive crystals

Propagation characteristics and stability properties of two-component composite screening photovoltaic spatial solitons have been analyzed in this paper. Employing paraxial ray approximation, we have identified a very large family of new two-component composite screening photovoltaic solitons in photovoltaic-photorefractive crystals. These composite solitons can exist only when the carrier beams have the same polarization, wavelength and are mutually incoherent. We have identified a wide parameter space involving spatial width and power where these composite solitons can exist as a stationary entity. The identified regions of existence of solitons give a deeper understanding of these solitons and reveal some interesting properties. We have shown that composite solitons with different widths cannot propagate as a stationary entity. A relevant example has been provided where the crystal is LiNbO₃ or BaTiO₃. In addition, we have shown that in the new family of solitons, a degenerate pair with equal peak power possesses bistable property. Both paraxial theory and numerical simulation show that the identified family of composite solitons is stable.     

Stable transition metal complexes of an all-metal antiaromatic molecule (Al4Li4): role of complexations

We propose for the first time a few examples of stable transition metal complexes of an all-metal antiaromatic molecule Al4Li4. We demonstrate that these all-metal species can be stabilized by complexation with 3d transition metals very similar to their organic counterpart, C4H4. Complexation to transition metal ions reduces the frontier orbital energies and introduces aromatic charactersitics. We consider a series of such complexes: [eta4-(Al4Li4)-Fe(CO)3, eta2,sigma2-(Al4Li4)-Ni, and (Al4Li4)2Ni] and compare and contrast their energetics with their organometallic counterparts. Fragmentation energy, orbital correlation energy analysis, and the nucleus-independent chemical shift (NICS) values support the complexation-induced stabilities in these systems.     

Invisible charginos and neutralinos from gauge boson fusion: a way to explore anomaly mediation

We point out that vector boson fusion at the Large Hadron Collider (LHC) can lead to useful signals for charginos and neutralinos in supersymmetric scenarios where these particles are almost invisible. The proposed signals are just two forward jets with missing transverse energy. It is shown that, in this way, one can put by far the strongest constraint on the parameter space of a theory with anomaly mediated supersymmetry breaking at the LHC. In addition, scenarios where the lightest neutralinos and charginos are Higgsino-like can give signals of the above type.     

Physicochemical Characteristics of Styrene-Butadiene Latex- modified Mortar Composite vis-à-vis Preferential Interactions

The interaction between styrene-butadiene rubber (SBR) film and the ions from C₂S and C₃S hydration of Portland cement mortar composites has been evaluated by Fourier Transform Infrared Spectroscopy (FTIR), and the morphology of the composites characterized with scanning electron microscopy (SEM). The specimen used was cured for 28 days. FTIR spectrum supports the interaction of SBR with cement in the composite. Compressive strength, bulk density and water absorption properties of the cured composites were tested. Addition of SBR latex in Portland cement mortar increases the compressive strength and decreases the water absorption. Bulk density study revels interface formation in the composite. The role of the interface in relation to compressive strength of the composite has been discussed. A simple Matrix System model is shown to account composition dependence of bulk density.     

Molecular Switching Behavior in Isosteric DNA Base Pairs

The structures and proton‐coupled behavior of adenine–thymine (A‐T) and a modified base pair containing a thymine isostere, adenine–difluorotoluene (A‐F), are studied in different solvents by dispersion‐corrected density functional theory. The stability of the canonical Watson–Crick base pair and the mismatched pair in various solvents with low and high dielectric constants is analyzed. It is demonstrated that A‐F base pairing is favored in solvents with low dielectric constant. The stabilization and conformational changes induced by protonation are also analyzed for the natural as well as the mismatched base pair. DNA sequences capable of changing their sequence conformation on protonation are used in the construction of pH‐based molecular switches. An acidic medium has a profound influence in stabilizing the isostere base pair. Such a large gain in stability on protonation leads to an interesting pH‐controlled molecular switch, which can be incorporated in a natural DNA tract.