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It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.  相似文献   
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LetK/F be a cyclic field extension of odd prime degree. We consider Galois embedding problems involving Galois groups with common quotient Gal(K/F) such that corresponding normal subgroups are indecomposable . For these embedding problems we prove conditions on solvability, formulas for explicit construction, and results on automatic realizability. Research supported in part by the Natural Sciences and Engineering Research Council of Canada grant R0370A01, as well as by the special Dean of Science Fund at the University of Western Ontario. Supported by the Mathematical Sciences Research Institute, Berkeley. Research supported in part by National Security Agency grant MDA904-02-1-0061.  相似文献   
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We determine the isomorphism class of the Brauer groups of certain nonrational genus zero extensions of number fields. In particular, for all genus zero extensions of the rational numbers that are split by , .

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The xi0 muon semileptonic decay has been observed for the first time with nine identified events using the KTeV beam line and detector at Fermilab. The decay is normalized to the xi0 beta decay mode and yields a value for the ratio of decay rates gamma(xi0 --> sigma+ mu- nu(mu))/gamma(xi0 --> sigma+ e- nu(e)) of [1.8(-0.5)(+0.7)(stat) +/- 0.2(syst)] x 10(-2). This is in agreement with the SU(3) flavor symmetric quark model.  相似文献   
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We consider Galois embedding problems such that a Galois embedding problem is solvable, where is a Galois subextension of . For such embedding problems with abelian kernel, we prove a reduction theorem, first in the general case of commutative -algebras, then in the more specialized field case. We demonstrate with examples of dihedral embedding problems that the reduced embedding problem is frequently of smaller order. We then apply these results to the theory of obstructions to central embedding problems, considering a notion of quotients of central embedding problems, and classify the infinite towers of metacyclic -groups to which the reduction theorem applies.

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