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361.
362.
In-Sung Song Yu Jeong Jeong Seung Hun Jeong Hye Jin Heo Hyoung Kyu Kim Sung Ryul Lee Tae Hee Ko Jae Boum Youm Nari Kim Kyung Soo Ko Byoung Doo Rhee Jin Han 《Experimental & molecular medicine》2013,45(10):e50
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a previous report, we demonstrated that changes in the expression of mitochondrial genes lead to changes in mitochondrial activity and bortezomib susceptibility or resistance, and their combined effects contribute to the differential sensitivity or resistance of MM cells to bortezomib. Here we report that the combination treatment of bortezomib and 2-methoxyestradiol (2ME), a natural estrogen metabolite, induces mitochondria-mediated apoptotic cell death of bortezomib-resistant MM KMS20 cells via mitochondrial reactive oxygen species (ROS) overproduction. Bortezomib plus 2ME treatment induces a higher level of cell death compared with treatment with bortezomib alone and increases mitochondrial ROS and Ca2+ levels in KMS20 cells. Pretreatment with the antioxidant N-acetyl-L-cysteine scavenges mitochondrial ROS and decreases cell death after treatment with bortezomib plus 2ME in KMS20 cells. Moreover, we observed that treatment with bortezomib plus 2ME maintains the activation of c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase kinase kinase 4/7 (MKK4/7). Collectively, combination treatment with bortezomib and 2ME induces cell death via JNK-MKK4/7 activation by overproduction of mitochondrial ROS. Therefore, combination therapy with specific mitochondrial-targeting drugs may prove useful to the development of novel strategies for the treatment of bortezomib-resistant MM patients. 相似文献
363.
Dr. Sang Soo Han Dr. Dong Hyun Jung Dr. Seung‐Hoon Choi Prof. Jiyoung Heo 《Chemphyschem》2013,14(12):2698-2703
We have used grand canonical Monte Carlo simulations with a first‐principles‐based force field to show that metal–organic frameworks (MOFs) with Li functional groups (i.e. C? Li bonds) allow for exceptional H2 uptake at ambient temperature. For example, at 298 K and 100 bar, IRMOF‐1‐4Li shows a total H2 uptake of 5.54 wt % and MOF‐200‐27Li exhibits a total H2 uptake of 10.30 wt %, which are much higher than the corresponding values with pristine MOFs. Li‐functionalized MOF‐200 (MOF‐200‐27Li) shows 11.84 wt % H2 binding at 243 K and 100 bar. These hydrogen‐storage capacities exceed the 2015 DOE target of 5.5 wt % H2. Moreover, the incorporation of Li functional groups into MOFs provides more benefits, such as higher delivery amount, for H2 uptake than previously reported Li‐doped MOFs. 相似文献
364.
Edington C Murata H Koepsel R Andersen J Eom S Kanade T Balazs AC Kolmakov G Kline C McKeel D Liron Z Russell AJ 《Langmuir : the ACS journal of surfaces and colloids》2011,27(24):15345-15351
Cell separation technology is a key tool for biological studies and medical diagnostics that relies primarily on chemical labeling to identify particular phenotypes. An emergent method of sorting cells based on differential rolling on chemically patterned substrates holds potential benefits over existing technologies, but the underlying mechanisms being exploited are not well characterized. In order to better understand cell rolling on complex surfaces, a microfluidic device with chemically patterned stripes of the cell adhesion molecule P-selectin was designed. The behavior of HL-60 cells rolling under flow was analyzed using a high-resolution visual tracking system. This behavior was then correlated to a number of established predictive models. The combination of computational modeling and widely available fabrication techniques described herein represents a crucial step toward the successful development of continuous, label-free methods of cell separation based on rolling adhesion. 相似文献
365.
An appended sector of two octet-colored scalars, each an electroweak doublet, is an interesting extension of the simple two Higgs doublet model motivated by the minimal flavor violation. Their rich CP violating interaction gives rise to a sizable electron electric dipole moment, besides the quark electric dipole moment via the two-loop contribution of Barr–Zee mechanism. 相似文献
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367.
Park Young Jin Lee K. B. Lee J. M. Hwang S. H. Heo D. H. Kim B. J. 《Journal of Radioanalytical and Nuclear Chemistry》2021,328(2):493-505
Journal of Radioanalytical and Nuclear Chemistry - Generally, short-lived medical isotopes and/or their generators are produced in nuclear reactors and cyclotrons. During the last decade, the... 相似文献
368.
We obtain Calderón–Zygmund-type gradient estimates below the duality exponent of very weak solutions to p-Laplacian-type elliptic equations with non-divergence datum by providing an analytic approach without using the fractional maximal function of order 1 for the non-divergence datum. 相似文献