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911.
912.
913.
Ho Yin Lo Jörg Bentzien Chuk C. Man Steven S. Pullen Josephine King John P. Wolak Gregory P. Roth 《Tetrahedron letters》2008,49(51):7337-7340
Based on information from molecular modeling, a series of 2-aminobenzimidazoles with pyrrole moieties were designed and synthesized as ITK antagonists. Results showed that a significant improvement of intrinsic and cell-based potency was achieved. X-ray crystallographic analysis of an inhibitor complex with ITK confirmed the prediction from the de novo design that the pyrrole moiety of the inhibitor would form an additional hydrogen bonding interaction with Glu436 in the catalytic domain, and hence improve overall binding affinity of the inhibitor. 相似文献
914.
Jong Hyeuk Lim Kyong Nam Kim Gwang Ho Gweon Jae Beom Park Geun Young Yeom 《Plasma Chemistry and Plasma Processing》2009,29(4):251-259
An internal-type linear inductive antenna, which is referred to as “double comb-type antenna”, was used as a large-area inductively
coupled plasma (ICP) source with a substrate area of 2,300 mm × 2,000 mm. The characteristics of the ICP source were investigated
for potential applications to flat panel display (FPD) processing. The source showed higher power transfer efficiency at higher
RF power and higher operating pressures. The power transfer efficiency was approximately 88.1% at 9 kW of RF power and a pressure
of 20 mTorr Ar. This source showed increasing plasma density and improved plasma uniformity with increasing RF power at a
given operating pressure. A plasma density >1.5 × 1011/cm3 and a plasma uniformity of approximately 11% was obtained at 9 kW of RF power and 15 mTor Ar using this internal ICP source,
which is applicable to FPD processing. 相似文献
915.
Ho CY Schleicher KD Jamison TF 《Synlett : accounts and rapid communications in synthetic organic chemistry》2009,2009(16):2565-2582
Recent advances using nickel complexes in the activation of unactivated monosubstituted olefins for catalytic intermolecular carbon-carbon bond-forming reactions with carbonyl compounds, such as simple aldehydes, isocyanates, and conjugated aldehydes and ketones, are discussed. In these reactions, the olefins function as vinyl- and allylmetal equivalents, providing a new strategy for organic synthesis. Current limitations and the outlook for this new strategy are also discussed. 相似文献
916.
This research work is concerned with the use of N‐benzoyl cyanoacetylhydrazine ( 3 ) in synthesizing several new heterocyclic compounds with potential biological activity, via its reaction with various chemical reagents. The synthesized derivatives have actually exhibited, upon screening, antibacterial and antifungal activities. 相似文献
917.
918.
A novel method to obtain racemic cyanohydrin silylethers by reaction of trimethylsilyl cyanide with a variety of aldehydes promoted by catalysis of SmI2 is reported. The corresponding cyanosilylethers were obtained in high yields (up to 99%) in solvent‐ free conditions at room temperature within a relatively short time using 0.01–0.5 mol% catalyst loadings. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
919.
Claude Sinner Cheyenne Ziegler Yun Ho Jung Xianli Jiang Faruck Morcos 《Entropy (Basel, Switzerland)》2021,23(2)
Two-component systems (TCS) are signaling machinery that consist of a histidine kinases (HK) and response regulator (RR). When an environmental change is detected, the HK phosphorylates its cognate response regulator (RR). While cognate interactions were considered orthogonal, experimental evidence shows the prevalence of crosstalk interactions between non-cognate HK–RR pairs. Currently, crosstalk interactions have been demonstrated for TCS proteins in a limited number of organisms. By providing specificity predictions across entire TCS networks for a large variety of organisms, the ELIHKSIR web server assists users in identifying interactions for TCS proteins and their mutants. To generate specificity scores, a global probabilistic model was used to identify interfacial couplings and local fields from sequence information. These couplings and local fields were then used to construct Hamiltonian scores for positions with encoded specificity, resulting in the specificity score. These methods were applied to 6676 organisms available on the ELIHKSIR web server. Due to the ability to mutate proteins and display the resulting network changes, there are nearly endless combinations of TCS networks to analyze using ELIHKSIR. The functionality of ELIHKSIR allows users to perform a variety of TCS network analyses and visualizations to support TCS research efforts. 相似文献
920.
Prof. Dr. So Won Youn Tae Yun Ko Young Ho Jang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(23):6736-6740
A Pd-catalyzed intermolecular oxidative annulation between N-Ts-anilines and styrenes was developed. This method offers a straightforward and robust approach to a wide range of 3-arylindoles using readily available starting materials with good functional-group tolerance and high regioselectivity and efficiency. Further elaboration of the products obtained from this process provided access to highly functionalized and structurally diverse indoles, for example, 3-(indol-3-yl)carbazoles, 1,9-dihydropyrrolo-[2,3-b]carbazoles, and 3′-aryl-3,5′-biindoles. 相似文献