Two circular cylinders in cross-flow: A review

Pairs of circular cylinders immersed in a steady cross-flow are encountered in many engineering applications. The cylinders may be arranged in tandem, side-by-side, or staggered configurations. Wake and proximity interference effects, which are determined primarily by the longitudinal and transverse spacing between the cylinders, and also by the Reynolds number, have a strong influence on the flow patterns, aerodynamic forces, vortex shedding, and other parameters. This paper reviews the current understanding of the flow around two “infinite” circular cylinders of equal diameter immersed in a steady cross-flow, with a focus on the near-wake flow patterns, Reynolds number effects, intermediate wake structure and behaviour, and the general trends in the measurements of the aerodynamic force coefficients and Strouhal numbers. A primary focus is on the key experimental and numerical studies that have appeared since the last major review of this subject more than 20 years ago.     

Electrical and mechanical properties of hot-pressed versus sintered LiTi2(PO4)3

The electrical and mechanical properties of hot-pressed versus sintered LiTi₂(PO₄)₃ were investigated. The hot-pressed LiTi₂(PO₄)₃ had a higher density and larger average grain size than the sintered material. As a result of these microstructural differences the hot-pressed material exhibited a higher total ionic conductivity and lower hardness. The electronic conductivity of both materials was the same and increased by a factor of about 10⁷ when the hot-pressed and sintered materials were heated under a reducing atmosphere.     

Domination critical graphs

A set of vertices S is said to dominate the graph G if for each v ? S, there is a vertex u ∈ S with u adjacent to v. The smallest cardinality of any such dominating set is called the domination number of G and is denoted by γ(G). The purpose of this paper is to initiate an investigation of those graphs which are critical in the following sense: For each v, u ∈ V(G) with v not adjacent to u, γ(G + vu) < γ(G). Thus G is k-y-critical if γ(G) = k and for each edge e ? E(G), γ(G + e) = k ?1. The 2-domination critical graphs are characterized the properties of the k-critical graphs with k ≥ 3 are studied. In particular, the connected 3-critical graphs of even order are shown to have a 1-factor and some stringent restrictions on their degree sequences and diameters are obtained.     

A visualization study of fluid-structure interaction between a circular cylinder and a channel bed

Flow visualization was used to study the fluid-structure interaction between a circular cylinder and a shallow turbulent open channel flow. The Reynolds number ranged from Re _D = 1500–4400 based on the cylinder diameter, and from Re _H =7,800?27,600 based on the channel hydraulic radius. The cylinder was mounted vertically on the channel bed and the flow depth-to-cylinder-diameter ratio was varied fromd/D=7.0?11.7. Tests were carried out over smooth and rough beds, with the rough beds being either permeable or impermeable. The study showed that the horseshoe vortex forming at the cylinder-bed junction affects many of the flow structures, including the mode of vortex shedding, the shear layer dynamics, the vortex formation length, and the width of the near-wake region. The influence of the horseshoe vortex can be recognized throughout the depth of flow; however, its influence decreases with an increase in distance from the channel bed. It was also possible to discern that the bed roughness resulted in a change to the above interaction and the permeability of the bed resulted in additional changes.     

Adaptation in a revised inner-hair cell model

A revised computational model of the inner-hair cell (IHC) and auditory-nerve (AN) complex was recently presented [Sumner et al., J. Acoust. Soc. Am. 111, 2178-2188 (2002)]. One key improvement is that the model reproduces the rate-intensity functions of low- (LSR), medium- (MSR), and high-spontaneous rate (HSR) fibers in the guinea-pig. Here we describe the adaptation characteristics of the model, and how they vary with model fiber type. Adaptation of the revised model for a HSR fiber is in line with an earlier version of the model [Meddis and Hewitt, J. Acoust. Soc. Am. 90, 904-917 (1991)]. In guinea-pig, poststimulus time histograms (PSTH) have been found to show less adaptation in LSR fibers. Evidence from chinchilla suggests that this is due to chronic adaptation resulting from short interstimulus intervals, and that fully recovered LSR fibers actually show more adaptation. However, the model is able to account for both variations of PSTH shape when fully recovered from adaptation. Interstimulus interval can also affect recovery in the model. The model is further tested against data previously used to evaluate models of AN adaptation. The tests are (i) recovery from adaptation of spontaneous rate and (ii) the recovery of response to acoustic stimuli ("forward masking"), (iii) the response to stimulus increments and (iv) decrements, and (v) the conservation of transient components. A HSR model fiber performs similarly to the earlier version of the model. However, there is considerable variation in response to increments and decrements between different model fibers.     

An Optimized SPME-GC-MS Method for Volatile Metabolite Profiling of Different Alfalfa (Medicago sativa L.) Tissues

Solid-phase microextraction (SPME) was coupled to gas chromatography mass spectrometry (GC-MS) and a method optimized to quantitatively and qualitatively measure a large array of volatile metabolites in alfalfa glandular trichomes isolated from stems, trichome-free stems, and leaves as part of a non-targeted metabolomics approach. Major SPME extraction parameters optimized included SPME fiber composition, extraction temperature, and extraction time. The optimized SPME method provided the most chemically diverse coverage of alfalfa volatile and semi-volatile metabolites using a DVB/CAR/PDMS fiber, extraction temperature of 60 °C, and an extraction time of 20 min. Alfalfa SPME-GC-MS profiles were processed using automated peak deconvolution and identification (AMDIS) and quantitative data extraction software (MET-IDEA). A total of 87 trichome, 59 stem, and 99 leaf volatile metabolites were detected after background subtraction which removed contaminants present in ambient air and associated with the fibers and NaOH/EDTA buffer solution containing CaCl₂. Thirty-seven volatile metabolites were detected in all samples, while 15 volatile metabolites were uniquely detected only in glandular trichomes, 9 only in stems, and 33 specifically in leaves as tissue specific volatile metabolites. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) of glandular trichomes, stems, and leaves showed that the volatile metabolic profiles obtained from the optimized SPME-GC-MS method clearly differentiated the three tissues (glandular trichomes, stems, and leaves), and the biochemical basis for this differentiation is discussed. Although optimized using plant tissues, the method can be applied to other types of samples including fruits and other foods.     

Nuclear recoil scintillation and ionisation yields in liquid xenon from ZEPLIN-III data

Scintillation and ionisation yields for nuclear recoils in liquid xenon above 10 keVnr (nuclear recoil energy) are deduced from data acquired using broadband Am-Be neutron sources. The nuclear recoil data from several exposures to two sources were compared to detailed simulations. Energy-dependent scintillation and ionisation yields giving acceptable fits to the data were derived. Efficiency and resolution effects are treated using a light collection Monte Carlo, measured photomultiplier response profiles and hardware trigger studies. A gradual fall in scintillation yield below ∼40 keVnr is found, together with a rising ionisation yield; both are in agreement with the latest independent measurements. The analysis method is applied to the most recent ZEPLIN-III data, acquired with a significantly upgraded detector and a precision-calibrated Am-Be source, as well as to the earlier data from the first run in 2008. A new method for deriving the recoil scintillation yield, which includes sub-threshold S1 events, is also presented which confirms the main analysis.     

Osteogenic differentiation of rat bone marrow stromal cells by various intensities of low-intensity pulsed ultrasound

Bone growth and repair are under the control of biochemical and mechanical signals. Low-intensity pulsed ultrasound (LIPUS) stimulation at 30 mW/cm² is an established, widely used and FDA approved intervention for accelerating bone healing in fractures and non-unions. Although this LIPUS signal accelerates mineralization and bone regeneration, the actual intensity experienced by the cells at the target site might be lower, due to the possible attenuation caused by the overlying soft tissue. The aim of this study was to investigate whether LIPUS intensities below 30 mW/cm² are able to provoke phenotypic responses in bone cells. Rat bone marrow stromal cells were cultured under defined conditions and the effect of 2, 15, 30 mW/cm² and sham treatments were studied at early (cell activation), middle (differentiation into osteogenic cells) and late (biological mineralization) stages of osteogenic differentiation. We observed that not only 30 mW/cm² but also 2 and 15 mW/cm², modulated ERK1/2 and p38 intracellular signaling pathways as compared to the sham treatment. After 5 days with daily treatments of 2, 15 and 30 mW/cm², alkaline phosphatase activity, an early indicator of osteoblast differentiation, increased by 79%, 147% and 209%, respectively, compared to sham, indicating that various intensities of LIPUS were able to initiate osteogenic differentiation. While all LIPUS treatments showed higher mineralization, interestingly, the highest increase of 225% was observed in cells treated with 2 mW/cm². As the intensity increased to 15 and 30 mW/cm², the increase in the level of mineralization dropped to 120% and 82%. Our data show that LIPUS intensities lower than the current clinical standard have a positive effect on osteogenic differentiation of rat bone marrow stromal cells. Although Exogen™ at 30 mW/cm² continues to be effective and should be used as a clinical therapy for fracture healing, if confirmed in vivo, the increased mineralization at lower intensities might be the first step towards redefining the most effective LIPUS intensity for clinical use.