Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two CYP1A1 polymorphisms [MspI (rs4646903); Ile462Val (rs1048943)] and breast cancer in a multicenter case-control study of 513 breast cancer cases and 447 controls in Korea. Women carrying the T allele of the CYP1A1 MspI polymorphism were found to have a 1.72-fold (95% CI 1.11-2.68) greater risk of developing breast cancer. No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer. Haplotype analysis of the two loci showed that the CA haplotype was associated with the lowest risk of breast cancer, and CA/CA diplotypes were associated with a lower risk of breast cancer [OR=0.28 (0.13-0.61)] than others/others diplotypes. Moreover, this reduced risk was more pronounced among women with a lower body mass index (BMI) [OR=0.18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer.     

Numerical simulation of shear effect on vortex shedding behind a square cylinder

This paper is concerned with the numerical simulation of the flow structure around a square cylinder in a uniform shear flow. The calculations were conducted by solving the unsteady 2D Navier–Stokes equations with a finite difference method. The effect of the shear parameter K of the approaching flow on the vortex-shedding Strouhal number and the force coefficients acting on the square cylinder is investigated in the range K=0·0–0·25 at various Reynolds numbers from 500 to 1500. The computational results are compared with some existing experimental data and previous studies. The effect of shear rate on the Strouhal number and the force acting on the cylinder has a tendency to reduce the oscillation. The Strouhal number, mean drag and amplitude of the fluctuating force tend to decrease as the shear rate increases, but show no significant change at low shear rate. Increasing the Reynolds number decreases the Strouhal number and increases the force acting on the cylinder. At high shear rate the shedding frequencies of the fluctuating drag and lift coefficients are identical. © 1997 John Wiley & Sons, Ltd.     

Functionalized polynorbornene dielectric polymers: Adhesion and mechanical properties

Within the microelectronics industry, there is an ongoing trend toward miniaturization coupled with higher performance. High glass-transition temperature polynorbornenes exhibit many of the key performance criteria necessary for these demanding applications. However, homopolynorbornene exhibits poor adhesion to common substrate materials, including silicon, silicon dioxide, aluminum, gold, and copper. In addition, this homopolymer is extremely brittle, yielding less than 1% elongation-to-break values. To address these issues, the homopolymer was functionalized to improve adhesive and mechanical properties. Attaching triethoxysilyl groups to the polymer backbone substantially improved the adhesion, but at the cost of increasing the dielectric constant because of the polarity of the functional group. Alkyl groups were also added to the backbone, which decreased the rigidity of the system, and resulted in significantly higher elongation-to-break values and a decrease in residual stress. The addition of an alkyl group slightly decreased the dielectric constant of the polymer as a result of an increase in molar volume. The coefficient of thermal expansion and modulus are also reported for the polynorbornene functionalized with triethoxysilyl groups using a multiple substrate approach. © 1999 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 37: 3003–3010, 1999     

Determination of active components of Ginkgo biloba in human urine by capillary high-performance liquid chromatography/mass spectrometry with on-line column-switching purification

Ginkgo biloba is one of the most popular herbal nutritional supplements, with terpene lactones and flavonoids being the two major active components. An on-line purification high-performance liquid chromatography/mass spectrometry (HPLC/MS) method was successfully developed for the quantitative determination of flavonoids and terpene lactones excreted in human urine after ingesting the herbal supplement. Satisfactory separation was obtained using a C18 capillary column made in-house with sample clean-up and pre-concentration achieved using a C18 pre-column with column switching. High selectivity and limits of detection of 1-18 ng/mL were achieved using a selected ion monitoring (SIM) scan in negative ion mode; the on-line solid-phase extraction (SPE) recovery of the active components in Ginkgo biloba determined in this study was greater than 75%.     

Source Characteristics of Aged Voice Assessed from Long-Term Average Spectra

This study is the first to investigate age-related changes in the source characteristics of dynamic speech using long-term average spectral analysis (LTAS). A total of 80 speakers divided equally by age and gender participated. All participants were healthy, active community members. From the first paragraph of the Rainbow Passage, spectral energy measurements were completed for all speakers at 50 frequency levels across the LTAS. In comparison with young women, elderly women demonstrated: (1) significantly higher spectral amplitude levels at the frequencies of 320, 6080, 6240, 6400, 6560, and 6720 Hz; (2) significantly lower levels at the frequencies of 3040 and 3200 Hz; and (3) a tendency toward higher levels at 160 Hz. These findings suggest that both young and elderly women demonstrate spectral features associated with breathy voice quality, while differing in the specific spectral regions in which breathiness is indicated. Elderly men demonstrated significantly higher spectral amplitude levels than young men at 160 Hz, as well as significantly lower levels at 1600 Hz. Findings for men provide acoustic support for previous laryngoscopic findings of an age-related increase in the incidence of glottal gaps.     

The Shape of Orthogonal Cycles in Three Dimensions

Let σ be a directed cycle whose edges have each been assigned a desired direction in 3D (East, West, North, South, Up, or Down) but no length. We say that σ is a shape cycle. We consider the following problem. Does there exist an orthogonal representation Γ of σ in 3D space such that no two edges of Γ intersect except at common endpoints and such that each edge of Γ has the direction specified in σ? If the answer is positive, we say that σ is simple. This problem arises in the context of extending orthogonal graph drawing techniques from 2D to 3D. We give a combinatorial characterization of simple shape cycles that yields linear time recognition and drawing algorithms.     

Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction

Background  

Taste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP₃, which is involved in both bitter and sweet transduction pathways. Several components of the bitter transduction pathway have been identified, including the T2R/TRB taste receptors, phospholipase C β2, and the G protein subunits α-gustducin, β3, and γ13. However, the identity of the IP₃ receptor subtype in this pathway is not known. In the present study we used immunocytochemistry on rodent taste tissue to identify the IP₃ receptors expressed in taste cells and to examine taste bud expression patterns for IP₃R3.     

Desynchronization of large scale delayed neural networks

We consider a ring of identical neurons with delayed nearest neighborhood inhibitory interaction. Under general conditions, such a network has a slowly oscillatory synchronous periodic solution which is completely characterized by a scalar delay differential equation with negative feedback. Despite the fact that the slowly oscillatory periodic solution of the scalar equation is stable, we show that the associated synchronous solution is unstable if the size of the network is large.

     

To transform maifanite powders from insulators to conductors by Sm gaseous penetration technology

Research on Chemical Intermediates - For the preparation of low-cost and eco-friendly conductive powders, a novel rare earth gaseous penetration technology was applied to modify maifanite powders....     

Modifying a branched surface to carry a foliation

We consider C¹ nonsingular flows on a closed 3-manifold under which there is no transverse disk that flows continuously back into its own interior. We provide an algorithm for modifying any branched surface transverse to such a flow ? that terminates in a branched surface carrying a foliation F precisely when F is transverse to ?. As a corollary, we find branched surfaces that do not carry foliations but that lift to ones that do.