Correction: Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation

Correction for ‘Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation’ by Kui Wu et al., Chem. Sci., 2021, 12, 1259–1271, DOI: 10.1039/D0SC06099B.

The authors regret that the reference to the bond-breaking bioorthogonal chemistry, termed ‘click-to-release’ was omitted from the original article. In addition, we would like to include a reference describing the synthesis of compound 1, which is an intermediate to the protodrugs described in the original article. These references are listed below as ref. 1 and 2.The Royal Society of Chemistry apologizes for these errors and any consequent inconvenience to authors and readers.     

Superconvergence error estimates of discontinuous Galerkin time stepping for singularly perturbed parabolic problems

Numerical Algorithms - A parabolic convection-diffusion-reaction problem is discretized by the non-symmetric interior penalty Galerkin (NIPG) method in space and discontinuous Galerkin (DG) method...     

Surface properties of laser processed ductile iron

On laser melt treatment,Sliding Wear of pearlitic ductile iron reduced from severe metallic wear to oxidative mild wear by nearly two orders of magnitude at 7.5 ms^–1 over a load range of 14–31 kg cm^–2; resistance toCavitation Erosion improved by a factor ofseven in corrosive media and surface hardness increased from 20–22 to 40–58 HR_c. Laser melting could effectively reduceCorrosion rates in dilute acids by nearly 40%.These improvements were caused by the ultrafine microstructure (1–41 ,DAS), microhardness (700–900,HV _0,1) and the consequent high resistance to plastic flow and subsurface crack initiation.In this investigation, pin-on-disc adhesive wear, ultrasonic vibratory cavitation erosion and potentiodynamic corrosion in synthetic sea water and 0.01 N H₂SO₄, were assessed after laser surface melting or transformation hardening of hyper-eutectic ductile iron, typically employed in automotive and marine engine components by using CO₂ CW or Nd-YAG pulsed high power laser. Also the processing parameters viz, beam power (P), scan rate (U), and specific energy intensity (P/UD _b ² ) for threshold and specific depth of transformation hardening or melting have been determined.     

Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides

The synthesis of a biaryl ether containing macrocyclic depsipeptide 1 was achieved in 6% overall yield. The desired macrocycle was constructed by cyclization of a phenol into eta(6)-ruthenium complex. The ruthenium metal was subsequently photolytically deprotected to obtain the macrocycle 1.     

Structural considerations from dielectric measurements on the aliphatic alcohols

Precise static dielectric constants are reported for methanol, ethanol, andn-propanol at 10,25, and 40° C and at pressures up to 3 kbar. The measurements were carried out by a low-frequency bridge method using a threeterminal, all-glass cell. An uncertainty of 0.05% is claimed for the data. The results are compared to data from previous investigations, whith the agreement in the absolute magnitude poor but the agreement in the pressure coefficient reasonable in most cases. The data are analyzed in terms of the Kirkwood correlation factorg _K as obtained from the Fröhlich equation. In all cases, theg _K factor decreases with increased pressure. The problems involved in calculating this factor from the experimental data are discussed, and it is shown that the trends ing _K are very dependent upon the assumptions made in isolating the liquid dipole moment from its gas-phase value. This fact also indicates that an interpretation of theg _K values in terms of stepwise association of correlation dipoles is premature at this time.