A number of palladium(II) complexes with Ph3P and aromatic amines as ligands having the general formula [(Ph3P)Pd(Ph3P)(NH2R)Cl2] {where R = Ph (1), m-ClC6H4(2), p-ClC6H5(3)} and [Pd(CH3NHPh)Cl2] (4), have been synthesized and characterized by elemental analysis, IR, 1H and 13C NMR. The X-ray crystal structure of [(Ph3P)Pd(m-ClC6H4NH2)Cl2] · CH2 Cl2(2) shows a distorted square planar environment around the Pd(II) ion with the P–Pd–N and Cl(1)–Pd–Cl(2) bond angles of 174.88(5)°
and 176.77(2)° respectively. The complexes were screened for enzyme inhibition activity against β-glucuronidase and found to be active. 相似文献
AbstractThe rhizomes of Bergenia ciliata (B. ciliata, Family: Saxifragaceae) are widely used for treating gastric ulcers in folk medicine in Asia. It was hypothesized that anti-ulcer activity of B. ciliata is due to its anti-Helicobacter pylori (H. pylori) activity. The anti-H. pylori activity was investigated on six clinical bacterial isolates using agar well-diffusion and broth micro-dilution methods. The anti-H. pylori activity of amoxicillin (standard) was the highest (Zone of inhibition; ZI?=?25?mm, minimum inhibitory concentration; MIC=0.125?µg/µL) whereas among all the extracts of the rhizomes, methanol extract showed the highest activity (ZI?=?16?mm, MIC?=?12.50?µg/µL). Bioassay guided isolation of methanol extract using chromatographic and crystallization techniques isolated bergenin (ZI?=?21mm, MIC?=?0.391µg/µL) as constituent responsible for anti-H. pylori activity. The present study describes for the first time anti-H. pylori activity and possible mechanism of anti-ulcer properties of rhizomes of B. ciliata.相似文献
Treatment of the 83%-trans-13CH3-labelled 1,6-dienoate 7 with Et2AlCl at–78° provided in high yield the ene product 9 containing 83% 13C localized in the olefinic C(8)-methylene group. Accordingly, H-transfer occurs exclusively from the trans-methyl group of 7 , consistent with a concerted ene process 7 9 thereby ruling out an intermediate cation 8 (Scheme 4). 相似文献
[reaction: see text] A facile procedure for the incorporation of N-methyl phenothiazine as the terminal nucleoside in oligodeoxynucleotides is reported. The phenothiazine nucleoside analogue is synthesized and then incorporated into DNA using an automated DNA solid-phase synthesizer. Phenothiazine-labeled oligodeoxynucleotides form stable B-form duplexes with higher melting temperatures compared to unlabeled DNA duplexes. 相似文献
The ac electrical properties of 5-10% Fe doped polycrystalline sample have been investigated by complex impedance analysis over the frequency and temperature ranges of 1-100 kHz and 77-300 K, respectively. The average normalized change (ΔZ′/Δf)/Z0 has been deduced for these Fe doped CMR samples which shows an increasing trend with iron doping. The most pronounced effect of frequencies is at Tc, with the increase of Fe doping it is observed that not only Tc is lowered substantially but also the height of the peaks of real part of impedance (Z′) is increased which in turn decreases considerably with the increase of the ac field. An equivalent circuit model, Rg(RgbCgb), i.e. a resistor-capacitor network, has been proposed to explain the impedance results at different temperatures. The plot between τ and 1/T gives a straight line from where relaxation time (τ0) has been deduced. The correlated barrier hopping (CBH) model has been employed and the binding energy of the defect states is estimated to be between 0.39 and 0.25 eV while the minimum hoping distance varies within the range of 2.93-5.21 Å for these 5-10% Fe doped LCM samples. 相似文献
Serotonin is an important neurotransmitter with wide-ranging functions throughout the central nervous system. There is strong
evidence to suggest that regulation of serotonergic gene expression might be related to genetic variability, and several studies
have focused on understanding the functional effects of specific polymorphisms within these genes on expression levels. However,
the combination of genotype together with gender and brain region could have an overall effect on gene expression. In this
study, we report expression patterns of five serotonergic genes (TPH1, TPH2, 5-HT2A, 5-HT2C, 5-HTT) in seven different human post-mortem brain regions (superior frontal gyrus, superior temporal gyrus, striatum, cerebellum,
hippocampus, midbrain and thalamus) using TaqMan™ real-time quantitative PCR. In addition, the effect of genotype and gender
on their expression levels was determined. 相似文献
Recently, a traditional remedy (Joshanda) has been replaced largely by modern ready-to-use dosage forms, which have not been compared to the original remedy. Therefore, the present study aimed to compare a number of modern dosage forms with traditional remedy. Seven brands, 3 batches each, were compared with a Lab-made formulation with reference to analytical (proximate analyses, spectroscopic and chromatographic metabolomes) and pharmacological profiles (anti-inflammatory and antibacterial activities). Chemical and pharmacological differences were found between Lab-made Joshanda and modern dosage forms. Such variations were also found within the brands and batches of modern formulations (p < 0.05). The Lab-made Joshanda showed significantly higher pharmacological activities as compared to modern brands (p ). The results of the present study indicate that modern dosage forms are unstandardised and less effective than the traditional remedy. Characteristic profiles obtained from Lab-made Joshanda may be used as reference to produce comparable dosage forms. 相似文献
This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females. All the participants signed the informed consent form and answered the public health questionnaire. Samples of buccal epithelial and peripheral blood cells were collected and analyzed through micronucleus and comet assays. The cells were evaluated for apoptosis and DNA damage. Results showed the association of patients’ family history with an increase in toxicogenetic damage before and during cancer therapy. On the other hand, patients with late-onset cancer also presented genetic instability before and during therapy, along with those who did not take sufficient vegetables and alternative therapies. A positive correlation was observed between the genetic instability and alternative therapies, while inverse correlation was recorded with the vegetable consumption. Results clearly explain that the nutritional aspects and alternative therapies influence the genetic instability before and during cancer therapies especially in radiotherapy treated patients. Our data could be used for the monitoring therapies and management of breast cancer patients.
In the present investigation, we have studied the effects of mixed convection heat and mass transfer on peristaltic flow of
Williamson fluid model in a vertical annulus. The governing equations of Williamson fluid model are simplified using the assumptions
of long wavelength and low Reynold’s number. An approximated analytical and numerical solutions are found for the velocity
field using (i) Perturbation method (ii) Shooting method. The comparisons of analytical and numerical solutions have been
presented. The expressions for pressure rise, velocity against various physical parameter are discussed through graphs. 相似文献
The flow of an Oldroyd 8-constant fluid between coaxial cylinders with variable viscosity is considered. The heat transfer analysis is also taken into account. An analytical solution of the non-linear problem is obtained using homotopy analysis method. The behavior of pertinent parameters is analyzed and depicted through graphs. 相似文献