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31.
Alexei Yu. Lukin Sergei V. Shevyakov Alexei V. Laptev Olga I. Davydova Vitali I. Shvets Olga V. Demina Yury P. Strokach Valery A. Barachevsky Michail V. Alfimov Sergei P. Gromov Artem I. Vedernikov Johan Lugtenburg Andrey A. Khodonov 《Journal of inclusion phenomena and macrocyclic chemistry》2004,49(1-2):153-161
An effective synthetic approach to the preparation of a new crown-ether vinylogs involving the Horner–Emmons olefination of carbonyl precursors with the use of C2- and C5-phosphonates was proposed. The effects of the conjugation chain length and the nature of the terminal polar functions in the phosphonate reagent on the yield and process stereoselectivity were discussed. 相似文献
32.
Timerbaev AR Aleksenko SS Polec-Pawlak K Ruzik R Semenova O Hartinger CG Oszwaldowski S Galanski M Jarosz M Keppler BK 《Electrophoresis》2004,25(13):1988-1995
Characterizing how platinum metallocomplexes bind to human serum albumin (HSA) is essential in evaluating anticancer drug candidates. Using cisplatin as a reference complex, the application of capillary electrophoresis (CE) to reliably assess drug/HSA interactions was validated. Since this complex is small compared to the size of the protein, the binding response could only be recognized when applying CE coupled to a (platinum) metal-specific mode of detection, namely inductively coupled plasma-mass spectrometry (ICP-MS). This coupling allowed for confirmation of a specific affinity of cisplatin and novel Pt complexes to HSA, measurement of the kinetics of binding reactions, and determination of the number of drug molecules attached to the protein. As the cisplatin/HSA molar ratio increased, the reaction rate became faster with a maximum on the kinetic curve appearing at about 50 h of incubation at 20 times excess of cisplatin. The reaction was characterized as a pseudo-first order reaction with the rate constant k = 0.003 min(-1) at 37 degrees C. When incubated with a 20-fold excess of cisplatin, HSA bound up to 10 mol of Pt per mol of the protein. This is indicative for a strong metal-protein coordination occurring at several HSA sites other than the only protein cysteine residue. Structural analogs of cisplatin, bearing aminoalcohol ligands, showed comparable protein binding reactivity and stoichiometry but a common equilibrium was not reached even after one week of incubation. Also apparent was a two-step mechanism of the binding reaction. Results demonstrated the suitability of CE-ICP-MS as a rapid assay for high-throughput studying of drug/HSA interactions. 相似文献
33.
Edwin Weber Claus Wimmer Ingeborg Csöregh Olga Gallardo 《Journal of inclusion phenomena and macrocyclic chemistry》1997,27(2):141-153
A novel host molecule, 1, suitable for crystalline lattice-type inclusion, has been synthesized, and its cocrystal formation ability has been investigated. Host 1 proved to be of potential use for organic solvent separation and retrieval, and a promising auxiliary for solidification of certain odorous substances. The crystal structures of the solvent-free host 1, and its complex with 1,4-dioxane (1 : 1), have been determined by single crystal X-ray diffraction. The structure of 1 (guest-free) is triclinic, P
, with a = 9.452(2), b = 10.359(3), c = 13.116(3) Å, = 101.80(2), = 106.53(1) and = 104.32(1)°. The spacious, propeller-like molecules are held together by weak van der Waals' forces. The dioxane inclusion compound is monoclinic, P21/a, with a = 15.050(1), b = 8.641(1) and c = 20.658(1) Å, and = 94.56(1)°, and contains two crystallographically independent guest molecules, both located around symmetry centres. The molecular packing seems to be governed by C—H···O type bonds (C···O = 3.31 and 3.48 Å) from the host to the dioxane oxygens. 相似文献
34.
T. A. Stepanova V. I. Sheichenko L. P. Smirnova V. I. Glyzin 《Chemistry of Natural Compounds》1981,17(6):520-526
Six flavanones have been isolated for the first time from Siberian tansy, and two of them have proved to be new compounds. 相似文献
35.
N. M. Smirnova N. M. Cherdantseva O. A. Burova V. M. Nesterov T. S. Safonova 《Chemistry of Heterocyclic Compounds》1990,26(7):811-815
6-Aminouracils and N-substituted derivatives are cyanoacetylated to give 5-cyanoacetyl-6-aminouracils. In the presence of bases these are converted to pyrido[2,3-d]pyrimidine-2,4,5-triones in high yields.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 971–975, July, 1990. 相似文献
36.
Martí MP Pino J Boqué R Busto O Guasch J 《Analytical and bioanalytical chemistry》2005,382(2):440-443
The aromatic composition of sugar cane spirits and, in general, of alcoholic beverages, is mainly influenced by the ageing process in wood barrels. There are several factors that affect the quality of the final aged product, but the time of the storage in the barrel is perhaps the most important one. Ageing time must therefore be controlled in order to detect counterfeits; however, this parameter is very difficult to control and, at present, there is no analytical method available to determine it. We propose a quantitative method for determining the ageing time of sugar cane spirits in oak barrels by using an electronic nose based on coupling directly a headspace sampler to a mass spectrometer (HS-MS), and multivariate calibration. The method developed is simple and provides, in 5 min, the ageing time of spirits with an accuracy of about 1 month. 相似文献
37.
T. V. Kulik V. N. Barvinchenko B. B. Palyanitsa O. V. Smirnova V. K. Pogorelyi A. A. Chuiko 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2007,81(1):83-90
The interaction of cinnamic acid with the surface of highly dispersed silica is studied. The mechanisms of adsorption, chemisorption, and thermal transformations of cinnamic acid on the silica surface are proposed. The kinetic parameters of the chemical reactions on the surface of silica are calculated. 相似文献
38.
Various high levels of theory have been applied to the characterization of two higher lying biradicaloid metastable singlet states of peroxynitrous acid. A singlet minimum (cis-2) was located that had an elongated O-O distance (2.17 A) and was only 12.2 kcal/mol [UB3LYP/6-311+G(3df,2p)+ZPVE] higher in energy than its ground-state precursor. A trans-metastable singlet (trans-2) was 10.9 kcal/mol higher in energy than ground-state HO-ONO. CASSCF(12,10)/6-311+G(d,p) calculations predict the optimized geometries of these cis- and trans-metastable singlets to be close to those obtained with DFT. Optimization of cis- and trans-2 within the COSMO solvent model suggests that both exist as energy minima in polar media. Both cis- and trans-2 exist as hydrogen bonded complexes with several water molecules. These collective data suggest that solvated forms of cis-2.3H(2)O and trans-2.3H(2)O represent the elusive higher lying biradicaloid minima that were recently (J. Am. Chem. Soc. 2003, 125, 16204) advocated as the metastable forms of peroxynitrous acid (HOONO). The involvement of metastable trans-2 in the gas phase oxidation of methane and isobutane is firmly established to take place on the unrestricted [UB3LYP/6-311+G(d,p)] potential energy surface (PES) with classical activations barriers for the hydrogen abstraction step that are 15.7 and 5.9 kcal/mol lower than the corresponding activation energies for producing products methanol and tert-butyl alcohol formed on the restricted PES. The oxidation of dimethyl sulfide and dimethyl selenide, two-electron oxidations, proceeds by an S(N)2-like attack of the heteroatom lone pair on the O-O bond of ground-state peroxynitrous acid. No involvement of metastable forms of HO-ONO was discernible. 相似文献
39.
Triolo A Russina O Hardacre C Nieuwenhuyzen M Gonzalez MA Grimm H 《The journal of physical chemistry. B》2005,109(46):22061-22066
A detailed investigation on the nature of the relaxation processes occurring in a typical room temperature ionic liquid (RTIL), namely, 1-butyl-3-methyl imidazolium hexafluorophosphate ([bmim][PF(6)]), is reported. The study was conducted using both elastic and inelastic neutron scattering over a wide temperature range from 10 to 400 K, accessing the dynamic features of both the liquid and glassy amorphous states. In this study, the inelastic fixed energy scan technique has been applied for the first time to this class of materials. Using this technique, the existence of two relaxation processes below the glass transition and a further diffusive process occurring above the glass-liquid transition are observed. The low temperature processes are associated with methyl group rotation and butyl chain relaxation in the glassy state and have been modeled in terms of two Debye-like, Arrhenius activated processes. The high temperature process has been modeled in terms of a Kohlraush-Williams-Watts relaxation, with a distinct Vogel-Fulcher-Tamman temperature dependence. These results provide novel information that will be useful in rationalizing the observed structural and dynamical behavior of RTILs in the amorphous state. 相似文献
40.
E. N. Fedoseeva A. V. Budruev L. A. Smirnova Yu. D. Semchikov V. B. Fedoseev 《Polymer Science Series A》2007,49(8):868-875
It has been shown that the interaction of chitosan and oligochitosan with unsaturated acrylic esters via the nucleophilic addition mechanism and their condensation with heptadecyl isocyanate yield hydrophobic alkyl-containing derivatives of the above polymers. The method of modification of oligochitosan in reactions via end functional groups is developed. 相似文献