Weighted Hamming metric structures

It is known that the binary generalized Goppa codes are perfect codes for the weighted Hamming metrics. In this paper, we present the existence of a weighted Hamming metric that admits a binary Hamming code (resp. an extended binary Hamming code) to be perfect code. For a special weighted Hamming metric, we also give some structures of a 2-perfect code, show how to construct a 2-perfect linear code and obtain the weight distribution of a 2-perfect code from the partial information of the code.     

Diarylthiazole and diarylimidazole selective COX-1 inhibitor analysis through pharmacophore modeling,virtual screening,and DFT-based approaches

Structural Chemistry - The current work is focused on in silico modeling of COX-1 inhibitors with enhanced safety gastric profile. A 5-point pharmacophore model, atom-based 3D quantitative...     

Langmuir probe study in the nonresonant current drive regime of helicon discharge

Characterization of the current drive regime is done for helicon wave-generated plasma in a torus, at a very high operating frequency. A radiofrequency-compensated Langmuir probe is designed and used for the measurement of plasma parameters along with the electron energy distributions in radial scans of the plasma. The electron energy distribution patterns obtained in the operational regime suggest that Landau damping cannot be responsible for the efficient helicon discharge in the present study. A typical peaked radial density profile, high plasma temperature and absence of an appreciable amount of energetic electrons for resonant wave-particle interactions, suggest that the chosen operational regime is suitable for the study of nonresonant current drive by helicon wave. Successful and significant current drive achieved in our device clearly demonstrates the capability of nonresonant current drive by helicon waves in the present operational regime.      

Cellulose as recyclable organocatalyst for ipso-hydroxylation of arylboronic acids

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign.     

Analytical study of wave diffraction by an irregular surface located on a flexible base in an ice-covered fluid

Meccanica - The reflection and transmission of surface waves propagating over an irregular surface located on a flexible base in an ice-covered fluid are analyzed within the context of linearized...     

Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation

Persulfides and polysulfides, collectively known as the sulfane sulfur pool along with hydrogen sulfide (H₂S), play a central role in cellular physiology and disease. Exogenously enhancing these species in cells is an emerging therapeutic paradigm for mitigating oxidative stress and inflammation that are associated with several diseases. In this study, we present a unique approach of using the cell''s own enzyme machinery coupled with an array of artificial substrates to enhance the cellular sulfane sulfur pool. We report the synthesis and validation of artificial/unnatural substrates specific for 3-mercaptopyruvate sulfurtransferase (3-MST), an important enzyme that contributes to sulfur trafficking in cells. We demonstrate that these artificial substrates generate persulfides in vitro as well as mediate sulfur transfer to low molecular weight thiols and to cysteine-containing proteins. A nearly 100-fold difference in the rates of H₂S production for the various substrates is observed supporting the tunability of persulfide generation by the 3-MST enzyme/artificial substrate system. Next, we show that the substrate 1a permeates cells and is selectively turned over by 3-MST to generate 3-MST-persulfide, which protects against reactive oxygen species-induced lethality. Lastly, in a mouse model, 1a is found to significantly mitigate neuroinflammation in the brain tissue. Together, the approach that we have developed allows for the on-demand generation of persulfides in vitro and in vivo using a range of shelf-stable, artificial substrates of 3-MST, while opening up possibilities of harnessing these molecules for therapeutic applications.

A persulfide/hydrogen sulfide generation strategy through artificial substrates for 3-mercaptopyruvate sulfurtransferase (3-MST) is reported, which enhances cellular persulfides, attenuates reactive oxygen species (ROS), and alleviates inflammation.     

Ultrasmall gold nanoparticles for highly specific isolation/enrichment of N-linked glycosylated peptides

In recent years, gold nanoparticles have been increasingly utilized as a promising material for biomedical analysis. We report here for the first time the synthesis of ultrasmall gold nanoparticles with core diameter of 1.2 nm functionalized with hydrazide groups and their use in isolation/enrichment of N-glycosylated peptides. Hydrazide-functionalized gold nanoparticles showed excellent stability in biological samples and exhibited a large capacity for peptide capturing. The captured peptides from tested standard glycoproteins were found to be highly specific as determined by Agilent HPLC chip and quadrupole time-of-flight (Q-TOF) mass spectrometer. The hydrazide-functionalized gold nanoparticles were successfully utilized in the isolation of a real proteome complex, which showed that more than 90% of captured product was glycopeptide. These results demonstrate that the ultrasmall gold nanoparticles can be used for a high-throughput analysis platform of glycoproteins.     

Temperature dependent energy relaxation time in AlGaN/AlN/GaN heterostructures

The two-dimensional (2D) electron energy relaxation in Al_0.25Ga_0.75N/AlN/GaN heterostructures was investigated experimentally by using two experimental techniques; Shubnikov-de Haas (SdH) effect and classical Hall Effect. The electron temperature (T_e) of hot electrons was obtained from the lattice temperature (T_L) and the applied electric field dependencies of the amplitude of SdH oscillations and Hall mobility. The experimental results for the electron temperature dependence of power loss are also compared with the current theoretical models for power loss in 2D semiconductors. The power loss that was determined from the SdH measurements indicates that the energy relaxation of electrons is due to acoustic phonon emission via unscreened piezoelectric interaction. In addition, the power loss from the electrons obtained from Hall mobility for electron temperatures in the range T_e > 100 K is associated with optical phonon emission. The temperature dependent energy relaxation time in Al_0.25Ga_0.75N/AlN/GaN heterostructures that was determined from the power loss data indicates that hot electrons relax spontaneously with MHz to THz emission with increasing temperatures.     

Oblique wave scattering by an impermeable ocean-bed of variable depth in a two-layer fluid with ice-cover

Within the framework of linearized theory, obliquely incident water wave scattering by an uneven ocean-bed in the form of a small bottom undulation in a two-layer fluid, where the upper layer has a thin ice-cover while the lower one has the undulation, is investigated here. In such a two-layer fluid, there exist two modes of time-harmonic waves—the one with lower wave number propagating just below the ice-cover and the one with higher wave number along the interface. An incident wave of a particular mode gets reflected and transmitted by the bottom undulations into waves of both the modes. Assuming irrotational motion, a perturbation technique is employed to solve the first-order corrections to the velocity potentials in the two-layer fluid by using Fourier transform appropriately and also to calculate the reflection and transmission coefficients in terms of integrals involving the shape function representing the bottom undulation. For a sinusoidal bottom topography, these coefficients are depicted graphically against the wave number. It is observed that when the oblique wave is incident on the ice-cover surface, we always find energy transfer to the interface, but for interfacial oblique incident waves, there are parameter ranges for which no energy transfer to the ice-cover surface is possible.