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881.
Saptashwa Chakraborty Dr. Bijoyananda Mishra Pratim Kumar Das Sandip Pasari Prof. Dr. Srinivas Hotha 《Angewandte Chemie (International ed. in English)》2023,62(6):e202214167
The synthesis of N-glycosides from stable glycosyl donors in a catalytic fashion is still challenging, though they exist ubiquitously in DNA, RNA, glycoproteins, and other biological molecules. Herein, silver-assisted gold-catalyzed activation of alkynyl glycosyl carbonate donors is shown to be a versatile approach for the synthesis of purine and pyrimidine nucleosides, asparagine glycosides and quinolin-2-one N-glycosides. Thus synthesized nucleosides were subjected to the oxidation–reduction sequence for the conversion of Ribf- into Araf- nucleosides, giving access to nucleosides that are otherwise difficult to synthesize. Furthermore, the protocol is demonstrated to be suitable for the synthesis of 2’-modified nucleosides in a facile manner. Direct attachment of an asparagine-containing dipeptide to the glucopyranose and subsequent extrapolation to afford the dipeptide disaccharide unit of chloroviruses is yet another facet of this endeavor. 相似文献
882.
Dr. Margherita Bazzoni Dr. Rituraj Mishra Dr. Jean-Nicolas Dumez 《Angewandte Chemie (International ed. in English)》2023,62(50):e202314598
Selective NMR experiments provide rapid access to important structural information, and are essential to tackle the analysis of large molecules and complex mixtures. Single-scan ultraselective experiments are particularly useful, as they can rapidly select signals that overlap with other signals. Here, we describe a novel type of single-scan ultraselective NMR experiments that is robust against the effects of translational molecular diffusion, and thus make it possible to improve significantly the sensitivity of the experiment. This will largely broaden the applicability of this powerful class of experiments. 相似文献
883.
Singh BK Bhojak N Mishra P Garg BS 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,70(4):758-765
Complexes of Cu(II) with bioactive carboxyamide ligands N',N'-bis(3-carboxy-1-oxoprop-2-enyl)2-amino-N-arylbenzamidine, N',N'-bis(3-carboxy-1-oxopropanyl)2-amino-N-arylbenzamidine and N',N'-bis(3-carboxy-1-oxophenelenyl)2-amino-N-arylbenzamidine have been synthesized and characterized by various physico-chemical techniques. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Vibrational spectra indicate coordination of amide and carboxylate oxygen of the ligands along with water molecules. Electronic spectra and magnetic susceptibility measurements reveal octahedral geometry for Cu(II) complexes. The EPR of the reported complex show g( parallel)>g( perpendicular)>2.0023 and G value within the range 2.08-4.49 are consistent with [Formula: see text] ground state in an octahedral geometry. The voltammogram of the copper(II) complex shows a quasi-reversible redox process and a simple one electron process assignable to the Cu(II)/Cu(I) couple. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the ligands and its copper complexes have been examined against the growth of bacteria and pathogenic fungi in vitro to evaluate their antimicrobial potential. The results indicate that the ligand and its metal complexes possess notable antimicrobial properties. 相似文献
884.
885.
The antibacterial screening of extracts of the leaves of Finlaysonia obovata with hexane, chloroform and alcohol was carried out against fresh water fish pathogenic bacteria viz., Micrococcus Sp. (multidrug resistant strain), Aeromonas hydrophila, Pseudomonas aeruginosa, Vibrio alginolyticus, Staphylococcus aureus, Escherichia Coli, Edwardsiella tarda by disc-assay method. The hexane and chloroform extracts were found active against four and five pathogens, respectively. The highly active chloroform extract was taken up for fractionations, further screening and isolation of secondary metabolites by chromatographic techniques. The triterpene acid Urs-3beta-hydroxy-12-en-27-oic acid (3), which is very rarely found from plant sources is isolated first time from this plant along with known compounds; Lupeol acetate (1) and beta-Sitosterol (2). This article presents for the first time all the spectral data for Urs-3beta-hydroxy-12-en-27-oic acid (3), which showed moderate activity against four pathogens. This is the first report of antibacterial activity of a triterpene against fish pathogens. 相似文献
886.
A new rhodamine-based reversible chemosensor (L1 ) is reported, which could bind Hg2+ and Cu2+ in aqueous methanol solution with detectable change in color. Cu2+ and Hg2+ ions responded differently toward the fluorescence output signals on binding to L1.L1 could also be used as a selective probe for monitoring Hg2+ adsorbed on bacteria using an optical microscope. 相似文献
887.
Mishra PP Jing J Francesconi LC Liu T 《Langmuir : the ACS journal of surfaces and colloids》2008,24(17):9308-9313
The self-assembly and the formation of "Blackberry" type supramolecular structures for a type of Yttrium-containing polyoxometalate (K 15Na 6(H 3O) 9[(PY 2W 10O 38) 4(W 3O 14)].9H 2O, or {P 4Y 8W 43}) macroanions is characterized by using static and dynamic light scattering techniques. {P 4Y 8W 43} macroions are found to form hollow, spherical, single-layer "blackberry" structures in water and water-acetone mixed solvents. Very interestingly, the blackberry size can be accurately controlled by either changing acetone content in water-acetone mixed solvents, or by changing solution pH in aqueous solution. The blackberry size increases with decreasing pH (lower charge density) or higher acetone content in the mixed solvent (lower dielectric constant) and the blackberry size can change in responding to the change of external conditions. This indicates that the {P 4Y 8W 43} macroanions possess the properties of both "strong electrolyte type" and "weak electrolyte type" macroions, as we outlined previously. This is due to the special chemical feature of such clusters, which can be treated as Na 2HPO 4-type electrolytes in solution. The kinetics of the blackberry formation can be controlled by temperature. 相似文献
888.
Mishra A Panda JJ Basu A Chauhan VS 《Langmuir : the ACS journal of surfaces and colloids》2008,24(9):4571-4576
Peptide-based vesicular structures have been the focus of research in the past decade for their potential application as drug delivery agents. We here report the self-assembly of amphiphilic dipeptides containing conformation-constraining alpha,beta-dehydrophenylalanine into nanovesicles. The vesicles can encapsulate small drug molecules such as riboflavin and vitamin B(12), bioactive peptides, and small protein molecules. The nanovesicles are resistant to treatment of a nonspecific protease, proteinase K, and are stable at low concentrations of monovalent and divalent cations. The vesicles are effectively taken up by actively growing cells in culture and show no observable cytopathic effects. These peptide-based nanostructures can be considered as models for further development as delivery agents for different biomolecules. 相似文献
889.
Sett P Mishra T Chowdhury J Ghosh M Chattopadhyay S Kumar Sarkar S Kumar Mallick P 《The Journal of chemical physics》2008,128(14):144507
Detailed investigation on the vibrational and electronic spectra has been carried out in order to study various properties of 2,2'-dipyridylketone molecule in its ground and excited electronic states. To get insight into the structural and symmetry features of the molecule, Raman excitation profiles of several normal modes have been analyzed. The polarized Raman spectra in different environments along with their IR counterpart have been critically surveyed and different normal modes have been assigned. The knowledge in regard to the positions of different excited electronic states has been acquired from the study of electronic absorption spectra. All the experimental observations have been substantiated and corroborated theoretically by the quantum chemical calculation. Possibility of exciton splitting of the 1La band has been explored both from theoretical and experimental points of view. 相似文献
890.
Devdutt Chaturvedi Nisha Mishra Amit K. Chaturvedi Virendra Mishra 《Monatshefte für Chemie / Chemical Monthly》2008,12(1):1467-1470
A single-step novel protocol for the preparation of symmetrical trithiocarbonates from a corresponding variety of primary,
secondary, and tertiary alcoholic tosylates using the Cs2CO3/CS2 system, was developed. This protocol is mild and more efficient than the reported methods. 相似文献