Investigation on radon concentration in drinking water to assess the whole body dose and excess lifetime cancer risk along coastal Kerala,India

Journal of Radioanalytical and Nuclear Chemistry - A numerical radiation transport methodology for predicting gamma emission tomographs was developed utilizing the deterministic fuel burn-up...     

Benedict's solution/ vitamin C: An alternative catalytic protocol for the synthesis of regioselective‐1,4‐disubstituted‐1H‐1,2,3‐triazoles at room temperature

A novel and highly efficient method for the synthesis of 1,4‐disubstituted‐1H‐1,2,3‐triazoles by copper‐catalyzed azide‐alkyne cycloaddition has been developed. This economic and sustainable protocol uses a readily available Benedict's solution/Vitamin C catalyst system affording a wide range of 1,4‐disubstituted‐1H‐1,2,3‐triazoles under mild conditions.     

Near-Infrared (>1000 nm) Light-Harvesters: Design,Synthesis and Applications

Organic molecules can absorb or emit light in UV, visible and infra-red (IR) region of solar radiation. Fifty percent of energy of solar radiation lies in the IR region of solar spectrum and extended π-conjugated molecules containing low optical band gap can absorb NIR radiations. Recently IR molecules have grabbed the attention of synthetic chemists. Although only few molecules have been reported so far such as derivative of BODIPY, naphthalimide, porphyrins, perylene, BBT etc., they have shown highest absorbing capacity towards greater than 1100 nm. These compounds have potential applications in different fields, such as for biomedical and optoelectronic applications. In this review, we present different classes of light-harvesters with harvesting range above 1000 nm.     

Catalyst Control in Switching the Site Selectivity of C−H Olefinations of 1,2-Dihydroquinolines: An Approach to Positional-Selective Functionalization of Quinolines

A unique approach to achieve site-selective C−H olefinations exclusively at the C-3- or C-8-positions in the quinoline framework has been developed by catalyst control. Distal C(3)−H functionalization is achieved by using palladium catalysis, whereas proximal C(8)−H functionalization is obtained by employing ruthenium catalysis. Switching the site selectivity within a single substrate directly indicates two diverse pathways, which are operating under the palladium- and ruthenium-catalyzed reaction conditions.     

Establishment of Guidelines for the Control of Glycosylation Reactions and Intermediates by Quantitative Assessment of Reactivity

Stereocontrolled chemical glycosylation remains a major challenge despite vast efforts reported over many decades and so far still mainly relies on trial and error. Now it is shown that the relative reactivity value (RRV) of thioglycosides is an indicator for revealing stereoselectivities according to four types of acceptors. Mechanistic studies show that the reaction is dominated by two distinct intermediates: glycosyl triflates and glycosyl halides from N‐halosuccinimide (NXS)/TfOH. The formation of glycosyl halide is highly correlated with the production of α‐glycoside. These findings enable glycosylation reactions to be foreseen by using RRVs as an α/β‐selectivity indicator and guidelines and rules to be developed for stereocontrolled glycosylation.     

Infinite co-minimal pairs involving lacunary sequences and generalisations to higher dimensions

In 2011, Nathanson proposed several questions on minimal complements in a group or a semigroup. The notion of minimal complements and being a minimal complement leads to the notion of co-minimal pairs which was considered in a prior work of the authors. In this article, we study which type of subsets in the integers and free abelian groups of higher rank can be a part of a co-minimal pair. We show that a majority of lacunary sequences have this property. From the conditions established, one can show that any infinite subset of any finitely generated abelian group has uncountably many subsets which is a part of a co-minimal pair. Further, the uncountable collection of sets can be chosen so that they satisfy certain algebraic properties.

     

A Rationally Designed Bimetallic Platinum (II)-Ferrocene Antitumor Agent Induces Non-Apoptotic Cell Death and Exerts in Vivo Efficacy

Despite phenomenal clinical success, the efficacy of platinum anticancer drugs is often compromised due to inherent and acquired drug resistant phenotypes in cancers. To circumvent this issue, we designed two heterobimetallic platinum (II)-ferrocene hybrids that display multi-pronged anticancer action. In cancer cells, our best compound, 2 , platinates DNA, produces reactive oxygen species, and has nucleus, mitochondria, and endoplasmic reticulum as potential targets. The multi-modal mechanism of action of these hybrid agents lead to non-apoptotic cell death induction which enables circumventing apoptosis resistance and significant improvement in platinum cross resistance profile. Finally, in addition to describing detail mechanistic insights, we also assessed its stability in plasma and demonstrate anticancer efficacy in an in vivo A2780 xenograft model. Strikingly, compared to oxaliplatin, our compound displays better tolerability, safety profile and efficacy in vivo.     

Creation of leather black dye film on copper through spin coating and drop casting,and comparative investigation of their corrosion behaviour in sodium chloride solutions

Journal of Solid State Electrochemistry - To protect Cu from corrosion, one of the efficient approaches is to coat the Cu substrate with passivation materials. This work investigates the ability of...     

On minimal complements in groups

The Ramanujan Journal - Let $$W,W'\subseteq G$$ be non-empty subsets in an arbitrary group G. The set $$W'$$ is said to be a complement to W if $$W\cdot W'=G$$ and it is minimal if no...