PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways

Pituitary adenylate cyclase-activating polypeptide (PACAP) was originally isolated from the ovine brain in 1989 as a novel hypothalamic hormone that potently activates adenylate cyclase to produce cyclic AMP in pituitary cells. This neuropeptide belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) superfamily, and exists in two amidated forms as PACAP38 (38-amino acid residues) and PACAP27 derived from the same precursor. The primary structure of PACAP has been remarkably conserved throughout evolution among tunicata, ichthyopsida, amphibia and mammalia, and a PACAP-like neuropeptide has also been determined in Drosophila. Both PACAP and its receptors are mainly distributed in the nervous and endocrine systems showing pleiotropic functions with high potency. There are three types of receptors with high PACAP-binding affinity and with different tissue-distribution patterns. All of them belong to G-protein-coupled receptor superfamily with seven transmembrane domains. PAC(1) is the PACAP-specific receptor and exists in at least eight splice variants which couple to different intracellular signal transduction pathways. VPAC(1) and VPAC(2) are the common receptors for both PACAP and VIP, which are coupled to adenylate cyclase. This review article presents and discusses an update on PACAP research and its pleiotropic physiological functions based on multiple receptor-mediated signaling mechanisms in both the central and peripheral nervous system, including the regulation of hypothalamic neurosecretion, homeostatic control of circadian clock and behavioral actions, involvement in learning and memory processes, neuroprotective effects such as anti-apoptosis and response to injury and inflammation, and neural ontogenetic functions on proliferation/differentiation processes from early stages.     

Preparation and properties of polyhedral oligomeric silsesquioxane polymers

Polyhedral oligomeric silsesquioxane (POSS) polymers were synthesized by the dehydrogenative condensation of (HSiO_3/2)₈ with water in the presence of diethylhydroxylamine followed by trimethylsilylation. Coating films were prepared by spin‐coating of the coating solution prepared by the dehydrogenative condensation of POSS. The hardness of the coating films was evaluated using a pencil‐hardness test and was found to increase up to 8H with increases in the curing temperature. Free‐standing film and silica gel powder were prepared by aging the coating solution at room temperature. The silica gel powder was subjected to heat treatment under air atmosphere to show a specific surface area of 440 m² g⁻¹ at 100 °C, which showed a maximum at 400 °C as 550 m² g⁻¹. Copyright © 2011 John Wiley & Sons, Ltd.     

Coupon Subset Collection Problem with Quotas

Methodology and Computing in Applied Probability - This paper studies the coupon subset collection problem with quotas, which is a variant of the classical coupon-collection problem. Specifically,...     

Power line monitoring system using fiber optic power supply

We propose a novel power-line-monitoring system using optical fibers for transmitting power as well as signal. The principle is experimentally confirmed with a system composed of a monitoring side with a 1.5-μm laser diode, transmission line of a single mode fiber, and a sensing side having an efficient photovoltaic (PV) cell, electrical junction sensor, and low power liquid crystal optical modulator (LCOM). The PV cell generates the electrical power in the sensing side with a conversion efficiency of 20%. The LCOM is driven with low power of less than 50 μW, modulates the laser light with a signal indicating the power line condition, and transmits the optical signal. The developed sensing unit produces an optical signal having an extinction ratio of 15 dB with low optical power of 1.8 mW. Five systems were in operation for two years, faithfully monitoring the oil pressure in electrical cables every 20 min without incident.     

Experimental studies on isentropic efficiency of a nonequilibriumMHD disk generator

Isentropic efficiency of the nonequilibrium MHD power generator was studied by a shock tube driven disk generator. Cesium seeded helium was used as a working gas. From the measurements of Faraday current density distribution, it was possible to estimate the general tendency of Joule dissipation in the generator. The Joule dissipation did not decrease due to the occurrence of nonuniformity of the plasma when external load resistance was low, although it decreased with the decrease in the load resistance when the load resistance was high. The electrical efficiency increased with the increase in applied magnetic flux density. This fact is thought to be caused by high Hall parameter and the stabilization of the plasma due to high degree of seed ionization     

Differentially protected benzenediboronic acids: divalent cross-coupling modules for the efficient synthesis of boron-substituted oligoarenes

On the basis of the boron-masking strategy, new divalent cross-coupling modules have been designed for the efficient synthesis of boron-substituted oligoarenes. The modules, i.e., monoprotected o-, m-, and p-benzenediboronic acid derivatives, undergo highly selective Suzuki-Miyaura coupling with sp2 iodides, bromides, chlorides, and triflates, affording coupling products in which the protected boronyl groups are left intact.