排序方式: 共有105条查询结果,搜索用时 31 毫秒
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A simple, selective, rapid, and economical reversed phase high performance liquid chromatography(RP-HPLC) method for the determination of doxofylline in the commercial dosage form has been developed and validated. The separation
and quantification were achieved on an HiQ Sil C 18 W column using a mobile phase of acetonitrile: buffer (50: 50), pH 3,
at a flow rate of 1 mL/min with detection of analyte at 272 nm. The separation was achieved within 3.1 ± 0.3 min for doxofylline
sample. The method showed good linearity in the range of 10–80 μg/mL. The intra and inter day RSD ranged from 0.37–0.53%.
The recovery (mean ± S.D.) of low, middle and high concentrations were 100.04 ± 0.80, 100.01 ± 0.20, 100.07 ± 0.30 respectively.
Limit of detection and limit of quantification were 0.03 and 0.1 μg/mL, respectively. 相似文献
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In this paper, wavelet based adaptive solver is developed for two dimensional advection dominating solute problem which generates sharp concentration front in the solution. In order to handle simultaneously smooth and shock-like behavior, the framework uses finite element discretization followed by wavelets for multiscale decomposition. Daubechies wavelet filter is incorporated to eliminate spurious oscillations at very high Peclet number. The developed solution is compared with the analytical solution to assess the accuracy and robustness. The advantages of the present method over the commonly used methods such as FDM and FEM for solving the problems which show non-physical oscillation in the numerical solution are demonstrated. 相似文献
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Sethiya Ayushi Sahiba Nusrat Teli Pankaj Soni Jay Agarwal Shikha 《Molecular diversity》2022,26(1):513-553
Molecular Diversity - Benzothiazole is a privileged scaffold in the field of synthetic and medicinal chemistry. Its derivatives and metal complexes possess a gamut of pharmacological properties and... 相似文献
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Dr. Shikha Sharma Dr. Suman Rathod Satya Prakash Yadav Arunavo Chakraborty Prof. Ashok K. Shukla Dr. Nagaphani Aetukuri Prof. Satish Patil 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(47):12172-12180
Redox flow batteries (RFBs) employing nonaqueous electrolytes could potentially operate at much higher cell voltages, and therefore afford higher energy and power densities, than RFBs employing aqueous electrolytes. The development of such high-voltage nonaqueous RFBs requires anolytes that are electrochemically stable, especially in the presence of traces of oxygen and/or moisture. The inherent atmospheric reactivity of anolytes mandates judicious molecular design with high electron affinity and electrochemical stability. In this study, diketopyrrolopyrrole (DPP)-based TDPP-Hex-CN4 is proposed as a stable redox-active molecule for anolytes in nonaqueous organic RFBs. We demonstrate organic RFBs using TDPP-Hex-CN4 as anolyte with unisol blue (UB) 1,4-bis(isopropylamino)anthraquinone and 1,4-di-tert-butyl-2,5-bis(2-methoxyethoxy)benzene (DBBB) as catholytes. Cyclic voltammetry measurements with scans repeated over 200 cycles were performed to establish the electrochemical stability of the redox pairs. Symmetric flow-cell studies show that TDPP-Hex-CN4 exhibits stable capacity up to 700 cycles. Redox flow cells employing TDPP-Hex-CN4 /UB and TDPP-Hex-CN4/DBBB as redox pairs demonstrate that DPP derivatives are propitious materials for anolytes in all organic nonaqueous RFBs. 相似文献
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Souradeep Roy Shalini Nagabooshanam Kushagra Krishna Shikha Wadhwa Nidhi Chauhan Utkarsh Jain Ranjit Kumar Ashish Mathur James Davis 《Electroanalysis》2020,32(9):2082-2089
L‐tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band‐aid for real time monitoring of L‐tyrosine by employing enzymatic bio‐sensor using α‐MnO2/tyrosinase. The smart band‐aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing performance was evaluated. Anodic current was found to vary linearly with the concentrations of L‐tyrosine in the range of 5 nM–500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 μA/nM/mm2 respectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health technologies, thus, fitting well into modern healthcare needs. 相似文献