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331.
Kim H Kumari P Laughlin M Hilbert MJ Indelicato SR Lim J Lin CC Nomeir AA 《Journal of chromatography. A》2003,987(1-2):243-248
Posaconazole (SCH 56592) is a novel broad spectrum triazole antifungal agent that is currently in phase III clinical trials for the treatment of systemic fungal infections. This study was initiated to determine if orally administered posaconazole to humans would result in the formation of active metabolite(s). Plasma samples from a multiple-rising dose study in healthy volunteers were analyzed by validated HPLC and microbiological methods. The HPLC analysis involved extraction with a mixture of organic solvent (methylene chloride-hexane) followed by separation on a C18 column and quantification by UV absorbance at 262 nm. The microbiological assay was performed utilizing an agar diffusion method using Candida pseudorropicalis ATCC 46764 as the test organism. Potency was determined by comparing the growth inhibition zones produced by the test sample to those produced by standard concentrations prepared in plasma. Individual and mean plasma concentration-time profiles were similar for both HPLC and microbiological assays. The area under the plasma concentration-time curves of the microbiological and HPLC results were similar with a mean (RSD) ratio of 105.5% 15.3%), indicating that there was no relevant biologically active metabolite of posaconazole in human plasma. 相似文献
332.
Russian Journal of Organic Chemistry - One-pot three-component synthesis of 1H-imidazol-5(4H)-one derivatives from (Z)-4-(arylmethylidene)-2-methyl-1,3-oxazol-5(4H)-one, methylamine, and... 相似文献
333.
The effect of thermal radiation on the non-Darcy mixed convection flow over a non-isothermal horizontal surface immersed in a saturated porous medium has been studied. The wall temperature is assumed to have a power-law variation with the distance measured from the leading edge of the plate. The non-linear coupled parabolic partial differential equations governing the flow have been solved numerically using a finite-difference scheme. For some particular cases, the self-similar solution has also been obtained. The heat transfer is found to be strongly influenced by the radiative flux number, buoyancy parameter, variation of wall temperature, non-Darcy parameter and the nature of the free stream velocity. 相似文献
334.
A nonsimilar boundary layer analysis is presented for the problem of mixed convection in powerlaw type nonNewtonian fluids along a vertical plate with powerlaw wall temperature distribution. The mixed convection regime is divided into two regions, namely,the forced convection dominated regime and the free convection dominated regime. The two solutions are matched. Numerical results are presented for the details of the velocity and temperature fields. A discussion is provided for the effect of viscosity index on the surface heat transfer rate. 相似文献
335.
The development of the momentum and thermal boundary layers over a semi-infinite flat plate has been studied when the external stream as well as the plate are impulsively moved with constant velocities. At the same time the temperature of the wall is suddenly raised from T∞, the temperature of the surrounding fluid, toT w and maintained at this temperature. The problem has been formulated in a new system of scaled coordinates such that fort?=0 it reduces to Rayleigh type of equation and fort? → ∞ it reduces to Blasius or Sakiadis type of equation. A new scale of time has been used which reduces the region of integration from an infinite region to a finite region which reduces the computational time considerably. The governing singular parabolic partial differential equations have been solved numerically using an implicit finite difference scheme. For some particular cases, analytical solutions have been obtained. The results show that there is a smooth transition from Rayleigh solution to Blasius or Sakiadis solution as the dimensionless timeξ increases from zero to one. The shear stress at the wall is negative for the friction parameterλ<0.5, positive forλ>0.5 and zero forλ=0.5. The zero shear stress at the wall does not imply separation but corresponds to the parallel flow. The surface heat transfer is strongly dependent on the Prandtl numberPr and increases with it. Also forPr<Pr 0, the surface heat transfer is enhanced as the friction parameterλ increases, but forPr>Pr 0 it get reduced. 相似文献
336.
A theoretical analysis of laminar free-convection flow over a vertical isothermal wavy surface in a non-Nevvtonian power-law fluid is considered. The governing equations are first cast into a nondimensional form by using suitable boundary-layer variables that substract out the effect of the wavy surface from the boundary conditions. The boundary-layer equations are then solved numerically by a very efficient implicit finite-difference method known as the Keller-Box method. A sinusoidal surface is used to elucidate the effects of the power-law index, amplitude wavelength, and Prandtl number on the velocity and temperature fields, as well as on the local Nusselt number. It is shown that the local Nusselt number varies periodically along the wavy surface. The wave-length of the local Nusselt number variation is half that of the wavy surface, irrespective of whether the fluid is a Newtonian fluid or a non-Newtonian fluid. Comparisons with earlier works are also made, and the agreement is found to be very good. 相似文献
337.
338.
Nisha Kumari Naresh Vyas 《Phosphorus, sulfur, and silicon and the related elements》2017,192(7):831-834
339.
340.
Ghosh Subhajit Das Tapas Sarma Haladhar D. Banerjee Sharmila 《Journal of Radioanalytical and Nuclear Chemistry》2017,311(1):263-268
Lipiodol functions as an embolizing agent for trans-arterial embolization and is used to deliver localized doses of chemotherapeutic drugs as well as ionizing radiation to cancerous tissue of the liver. Therefore, an attempt was made to prepare 68Ga-labeled lipiodol, which may have potential as a PET radiotracer for imaging of liver cancer. 68Ga-labeled lipiodol was prepared by a two-step procedure involving formation of highly lipophilic 68Ga-oxine complex followed by its dispersion in lipiodol. Preliminary biological evaluation in normal Wistar rats revealed satisfactory hepatic retention with insignificant uptake in any other major organ/tissue indicating promising potential of the agent.
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